Penn researchers find targeted therapy combination overcomes treatment resistance in li...(idual the immune system uses the TRAIL p...),Health

Date:4/13/2008

idual, the immune system uses the TRAIL pathway to rid the body of unwanted cells, including precancerous ones. Once cancer develops, however, the cells often become less responsive to TRAIL activation, in part because of an overabundance of a protein called Mcl-1, according to Dr. El-Deiry. His team found that sorafenib reduces the amount of Mcl-1 in the cancer cells, restoring their sensitivity to TRAIL-induced cell death.

Although the Penn investigators focused their current report on liver cancer, they discovered that the sorafenib-TRAIL combination also kills colon cancer cell in vitro and in animal models.

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Contact: Olivia Fermano Olivia.Fermano@uphs.upenn.edu 215-349-5653 University of Pennsylvania School of Medicine Source:Eurekalert

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