Navigation Links
Penn researchers find new role for cancer protein p53
Date:3/2/2011

PHILADELPHIA - The gene for the protein p53 is the most frequently mutated in human cancer. It encodes a tumor suppressor, and traditionally researchers have assumed that it acts primarily as a regulator of how genes are made into proteins. Now, researchers at the University of Pennsylvania School of Medicine show that the protein has at least one other biochemical activity: controlling the metabolism of the sugar glucose, one of body's main sources of fuel. These new insights on a well-studied protein may be used to develop new cancer therapies.

Xiaolu Yang, PhD, associate professor of Cancer Biology at the Abramson Family Cancer Research Institute, along with Mian Wu, PhD, at the University of Science and Technology of China and Nanjing University, report in the current issue of Nature Cell Biology that p53 controls a molecular crossroads in the cell's glucose metabolic pathway.

They found that p53 physically binds to and inhibits an enzyme -- glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the first step of the pathway. If p53 can't do its intended job, cells grow out of control.

Blocking this pathway shunts glucose away from energy storage and towards making genetic building blocks and lipids that contribute to cells' proliferation. p53 normally serves to dampen synthesis of molecules and cell reproduction by forcing the cell to take up less glucose.

In tumors, more than half of which carry mutations in the p53 gene, this routing function is abolished, enabling cells to build biomass and divide with abandon.

The findings provide a biochemical explanation for the Warburg effect, which explains how cancer cells, regardless of type, seem inevitably to boost their glucose consumption, but not in an energy efficient way.

"We found a connection between the most frequently mutated gene in cancer cells and how that mutation contributes to tumor growth," says Yang.

Making a Choice
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. UCSF researchers uncover hormone pathway to fatty liver disease
2. Researchers pinpoint patients who receive greatest benefit from heart failure treatment
3. IDIBELL researchers discover a substance against the dark genome of cancer
4. Wayne State University researchers publish results settling multiple sclerosis debate
5. E-health must be a priority, researchers say
6. Mayo Clinic researchers confirm value of therapeutic hypothermia after cardiac arrest
7. Mayo researchers, Rochester educators, students to present at science conference
8. Researchers work at the frontiers of islet cell transplantation
9. Brain Appears to Be a Task Machine, Researchers Say
10. Researchers develop outline that may help weigh benefits of new imaging technologies
11. University of Minnesota researchers study the use of computer vision to diagnose mental disorders
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn researchers find new role for cancer protein p53
(Date:7/11/2014)... 2014 The report, “Specialty Synthetic ... & Geography - 2018,” defines and segments the ... an analysis and forecast of the volumes and ... (Para aramids, meta aramids, UHMW Polyethylene, carbon fiber, ... fiber, PBI fiber, PBO fiber, and liquid crystal ...
(Date:7/11/2014)... -- In people with sex addiction, pornography affects the ... in drug addicts as they consume drugs, a new ... activity between patients who have compulsive sexual behavior and ... study author Dr. Valerie Voon, of the University of ... Voon,s research involved 19 men with sex addiction ...
(Date:7/11/2014)... Alliance for Cancer Gene Therapy, ... exclusively to cell and gene therapies for cancer ... the organization as Senior Development Officer. , Corday ... securing gifts and addressing influential donors. Prior to ... for NewYork Presbyterian Hospital/Columbia University Medical Center, where ...
(Date:7/11/2014)... Ohio (PRWEB) July 11, 2014 As ... 7/10/14) and FiercePharma (Weintraub 7/11/14), a significant number of ... blood sugar, abdominal issues and even death from the ... , According to the Times report , a ... in 2013 reported by patients was almost 14% of ...
(Date:7/11/2014)... -- Delaying surgery to repair damage to the anterior cruciate ... the knee -- could increase a young athlete,s risk for ... of 130 patients, aged 8 to 16, who had ACL ... six weeks after their injury, 37 had surgery six to ... three months after their injury. The youngsters who had ...
Breaking Medicine News(10 mins):Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 2Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 4Health News:Brains of Sex Addicts May Be Wired Like Those of Drug Addicts, Study Finds 2Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 2Health News:Alliance for Cancer Gene Therapy (ACGT) Welcomes Joshua Corday as Senior Development Officer 3Health News:Acthar’s Deadly Adverse Events Revealed 2Health News:Acthar’s Deadly Adverse Events Revealed 3Health News:Delaying Kid's Knee Surgery Could Be a Bad Play, Study Finds 2
... system cells sent to kill them, study finds , , ... a cache of molecular weapons that helps make community-associated ... Though more work must be done, the study "provides ... successful in causing infection and gives a starting point ...
... Mitch,Daniels joined executives from Medco Health Solutions, Inc. ... plans to build the world,s largest and most,advanced ... demand for lower-cost medicines. The new 318,000-square-foot,pharmacy, slated ... area equivalent to,six and a half football fields ...
... Nov. 12 PartsSource, the nation,s leading,supplier of ... CEO, A. Ray Dalton has been selected as ... for 2007. The "Dively Award" is given,to executives ... in creating new businesses throughout their professional,career. ...
... in language assistance services affect quality of,patient care, ... largest,hospital chains is failing to provide language assistance ... filed today with the Office for,Civil Rights of ... The,complaint, which was filed by the American Federation ...
... smoking-prevention strategy that targets black fourth-graders and their parents ... Researchers want to know if they can keep these ... to Dr. Martha S. Tingen, nurse researcher at the ... Program Leader for Cancer Prevention and Control, MCG Cancer ...
... serious enough to require hospitalization are much less likely ... antiviral medications, according to a new study published in ... available online. While previous clinical trials have shown the ... if they were treated within 48 hours of the ...
Cached Medicine News:Health News:Key to MRSA Virulence in Community Discovered 2Health News:Key to MRSA Virulence in Community Discovered 3Health News:Medco to Build World's Largest, Most Advanced Automated Pharmacy in Central Indiana 2Health News:Medco to Build World's Largest, Most Advanced Automated Pharmacy in Central Indiana 3Health News:Medco to Build World's Largest, Most Advanced Automated Pharmacy in Central Indiana 4Health News:Medco to Build World's Largest, Most Advanced Automated Pharmacy in Central Indiana 5Health News:Language Assistance Lacking at Resurrection Hospitals 2Health News:Language Assistance Lacking at Resurrection Hospitals 3Health News:Anti-smoking strategy targets fourth-graders, parents in rural and urban Georgia 2Health News:Anti-smoking strategy targets fourth-graders, parents in rural and urban Georgia 3Health News:Antivirals reduce deaths from flu in hospitalized patients 2
(Date:7/10/2014)... 11, 2014  Major advances in radiation therapy ... being highlighted in a three-day Oncology Summit taking ... July, 2014.  Renowned national and international cancer experts from ... and exchange knowledge on modern technologies making treatment ... The Summit will address a ...
(Date:7/10/2014)... , July 10, 2014  Breg, Inc., a ... has launched the FreeRunner™ knee brace with new ... from patella mal-tracking return to active lifestyles.  FreeRunner,s ... other braces, providing support when patients need it ... they don,t. Patellofemoral issues are the ...
(Date:7/10/2014)... , July 10, 2014 Yesterday, former ... (Moberg) medical device manufacturing facility. Rep. Kennedy and ... neurological monitors facilitate cutting-edge research in neurological disease ... and mental health advocate, Garen Staglin , ... to fostering fundamental changes that will radically accelerate ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2
... WAUKESHA, Wis., Sept. 29 MedPro Imaging, a premier ... of its Ultrasound Transducer Repair Division.  Based on proprietary ... MedPro Imaging will offer high quality computer-based transducer repair ... industry on probe exchange programs. "The industry ...
... 29 Crosstex International, a subsidiary of ... today the publication of sponsored research that suggests a ... commonly referred to as surgical masks, than previously understood. ... mask or respirator is most effective when worn by ...
Cached Medicine Technology:MedPro Imaging Launches Ultrasound Transducer Repair Division 2New Mask Study Supports CDC's Updated Guidance for Seasonal Flu Prevention Strategies 2New Mask Study Supports CDC's Updated Guidance for Seasonal Flu Prevention Strategies 3
Inquire...
VACUETTE paediatric tubes have decreased sample volumes and are ideal for small childrens' veins and geriatric patients....
Plastic Citrate Tube, .109M / 3.2%...
Inquire...
Medicine Products: