Navigation Links
Penn researchers find key developmental pathway activates lung stem cells
Date:6/17/2008

PHILADELPHIA Researchers from the University of Pennsylvania School of Medicine found that the activation of a molecular pathway important in stem cell and developmental biology leads to an increase in lung stem cells. Harnessing this knowledge could help develop therapies for lung-tissue repair after injury or disease. The investigators published their findings online last week in advance of print publication in Nature Genetics.

"The current findings show that increased activity of the Wnt pathway leads to expansion of a type of lung stem cell called bronchioalveolar stem cells," says senior author Edward Morrisey, Ph.D., Associate Professor of Medicine and Cell and Developmental Biology.

"This information will give us a more extensive basic understanding of Wnt signaling in adult tissue repair in the lung and other tissues and also start to help us determine whether pharmacological activation or inhibition of this pathway can be utilized for treatments," explains Morrisey, who is also the Scientific Director of the Penn Institute for Regenerative Medicine.

Activation of the Wnt signaling pathway leads to expansion, or increase in number, of bronchioalveolar stem cells in the lung. A protein called GATA6 inhibits Wnt signaling by directly regulating the expression of another protein in the Wnt pathway called frizzled 2 (Fzd2).

Wnt signaling is a major pathway in stem cell biology. The finding that GATA6 negatively regulates Wnt signaling and that GATA6 has been shown to play important roles in embryonic stem cell replication and differentiation suggests that these two pathways are linked not only in lung stem cells but in other tissues where they play important roles including the heart, gut, and pancreas.

"We were surprised by the robust activation of Wnt signaling after loss of GATA6 expression in the lung," says Morrisey. "Such a robust activation is rarely observed."

Wnt signaling can be phar
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... developed a way to detect and measure cancer levels ... with tails of synthetic DNA., A team led by ... gold nanoparticles to target and bind to fragments of ... which can indicate the presence and stage of breast ... a cell can be determined by examining the specific ...
(Date:4/23/2014)... an important brain receptor has a dramatic effect against ... a University at Buffalo animal study has found. , ... a novel lead compound for treating cocaine addiction, for ... published as an online preview article in Neuropsychopharmacology ... RO5263397, severely blunted a broad range of cocaine addiction ...
(Date:4/23/2014)... April 23, 2014Men whose testosterone falls below normal levels ... be overweight and have heart disease and type 2 ... testosterone-deficient men for further testing and possible treatment is ... Health , a peer-reviewed publication from Mary Ann Liebert, ... Journal of Men,s Health website at ...
(Date:4/23/2014)... accessible detection methods that can rapidly screen a ... single cell inside that population has been seriously ... , In the Royal Society of Chemistry journal ... he and his coworkers have developed a novel ... protein ( Chem. Sci. , 2014, DOI: 10.1039/C4SC00578C, ...
(Date:4/23/2014)... of probiotics, antioxidants and other nutritional compounds, more and ... is getting in on the action. But legitimate skepticism ... industry is responding with clinical research to shore up ... Chemical & Engineering News (C&EN), the weekly news ... Bomgardner, a senior editor at C&EN, writes that about ...
Breaking Medicine News(10 mins):Health News:Gold nanoparticles help target, quantify breast cancer segments in a living cell 2Health News:Novel compound halts cocaine addiction and relapse behaviors 2Health News:Following a protein's travel inside cells is key to improving patient monitoring, drug development 2
... , , , MOUNTAIN VIEW, Calif., July ... system solutions to acute healthcare facilities, today announced results for its second quarter ... results: Revenue for the second quarter of 2009 was $52.6 million, up ... million or 16.9% from the second quarter of 2008. , ...
... , LANCASTER, Pa., July 23 Eastern Insurance Holdings, ... to release financial results for the second quarter ended June 30, ... 2009. , , EIHI will ... a.m. ET to review the Company,s 2009 second quarter results. The ...
... in production is hampering efforts, but a nasal spray version ... million: that,s the number of doses of injectable swine flu ... October, with more doses coming in the form of a ... each person getting two doses spread a month apart, the ...
... , , PITTSBURGH, July 23 ... stopping in Pennsylvania throughout the week of July 27-31 at ... access information on programs that provide prescription medicines for free ... 8.2 percent -- compared to 5.1% a year ago -- ...
... dogma has been that bone-forming cells, derived from the body,s ... skeleton. However, new research shows that specialized cells in the ... from the bone marrow and that these bloodstream cells are ... skeleton. This work, published online this month in the journal ...
... , , NORTH BERGEN, N.J., July ... Industries Inc., today announced that it has filed a registration statement on ... proposed initial public offering of its common stock. Upon consummation of ... shares of common stock to be sold in the offering are expected ...
Cached Medicine News:Health News:Omnicell Announces Second Quarter 2009 Results 2Health News:Omnicell Announces Second Quarter 2009 Results 3Health News:Omnicell Announces Second Quarter 2009 Results 4Health News:Omnicell Announces Second Quarter 2009 Results 5Health News:Omnicell Announces Second Quarter 2009 Results 6Health News:Omnicell Announces Second Quarter 2009 Results 7Health News:Omnicell Announces Second Quarter 2009 Results 8Health News:Omnicell Announces Second Quarter 2009 Results 9Health News:Omnicell Announces Second Quarter 2009 Results 10Health News:Omnicell Announces Second Quarter 2009 Results 11Health News:Omnicell Announces Second Quarter 2009 Results 12Health News:Eastern Insurance Holdings, Inc. to Release 2nd Quarter 2009 Financial Results 2Health News:Eastern Insurance Holdings, Inc. to Release 2nd Quarter 2009 Financial Results 3Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 2Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 3Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 4Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 5Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 6Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 7Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 8Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 9Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 10Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 11Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 12Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 13Health News:U.S. Expects 160 Million Doses of Swine Flu Vaccine by October 14Health News:Partnership for Prescription Assistance Prepared to Help Pennsylvania Workers Hurt by Recession 2Health News:Partnership for Prescription Assistance Prepared to Help Pennsylvania Workers Hurt by Recession 3Health News:Partnership for Prescription Assistance Prepared to Help Pennsylvania Workers Hurt by Recession 4Health News:Bone from blood: Circulating cells form bone outside the normal skeleton, Penn study finds 2Health News:Vitamin Shoppe Files Registration Statement for Initial Public Offering of Common Stock 2Health News:Vitamin Shoppe Files Registration Statement for Initial Public Offering of Common Stock 3
(Date:1/15/2014)... Most osteoporosis patients want a choice in the ... sponsored by Mission Pharmacal Company. The survey, conducted by ... support community, revealed that 74 percent of osteoporosis patients ... form other than a pill or a tablet. ...
(Date:1/15/2014)... As health officials across the Midwest warn against the ... Michigan will offer free diagnostic testing ... pharmacists to administer tests and, in some cases, fill the ... in the study. The Grand Rapids, ...
(Date:1/15/2014)... the leading health care supply chain expertise, analytics and ... national contracts that expand its portfolio to provide hospital ... These include manufacturer product and service agreements, as well ... IT consulting support. New Novation agreements ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2
... MabVax Therapeutics Inc., a privately held clinical stage ... based therapies to address the unmet medical need of preventing ... in a Phase II clinical trial aimed at assessing the ... the recurrence of sarcoma. The clinical trial will enroll 126 ...
... NEW YORK , July 22 Reportlinker.com announces that a new market ... , , ... , http://www.reportlinker.com/p0240598/Wireless-Medical-Technologies-2007-2010.html ... Wireless Medical Technologies work on the basis of ...
Cached Medicine Technology:MabVax Therapeutics Initiates Phase II Clinical Trial of Vaccine to Prevent Recurrent Sarcoma 2MabVax Therapeutics Initiates Phase II Clinical Trial of Vaccine to Prevent Recurrent Sarcoma 3Reportlinker Adds Wireless Medical Technologies 2007-2010 2Reportlinker Adds Wireless Medical Technologies 2007-2010 3Reportlinker Adds Wireless Medical Technologies 2007-2010 4
Automatic tangent screen with plane type central field tester. Static, quantitative perimetry....
... represents the latest breakthrough in visual ... the Humphrey Matrix will help you ... and assess treatment alternatives. Enhanced patient ... complete long-term glaucoma care for your ...
Preference Toric quarterly planned replacement lenses are durable, easy to handle and virtually maintenance free. Meeting the needs of those suffering from astigmatism, these soft contact lenses are ...
... and disposable lens convenience for those with ... want crisp, clear vision with the convenience ... Vertex Toric lenses are manufactured using our ... a perfect edge on every lens. This ...
Medicine Products: