Navigation Links
Penn researchers find genetic link to leukemias with an unknown origin
Date:2/18/2010

s of leukemia include breaks and reformations in chromosomes called translocations.

The ease with which the researchers were able to detect IDH mutations in tumor samples, and the ability to identify patients with these mutations due to the presence of increased 2HG gives hope for better detection of AML and suggests that blocking the production of 2HG might reverse the ability of the mutant genes to maintain the leukemic cells.

"If we're able to block tumors from producing 2HG, perhaps we would be able to stop the patient's leukemia," states Thompson. Exactly why 2HG production leads to leukemia is not yet clear. It does not appear to act like other cancer-causing metabolites which induce further mutations. One possibility raised in the manuscript is that 2HG accumulation may block the ability of the leukemic cells to differentiate into normal blood cells.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-459-0544
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn researchers find genetic link to leukemias with an unknown origin
(Date:7/14/2014)... 14, 2014 The inability to ignore irrelevant stimuli ... by individuals diagnosed with schizophrenia, reports a new study ... , Our brains are usually good at focusing on ... filtering out the "noise" or thoughts that aren,t relevant. ... part to a problem with this filtering process, which ...
(Date:7/14/2014)... 2014)In the 2,500+ years that have passed since ... it has been used to treat a number ... and vomiting, stroke rehabilitation, headaches, menstrual cramps, asthma, ... a few. Now, a meta-analysis of randomized ... in Menopause , the journal of The ...
(Date:7/14/2014)... 2014 According to a recent ... have discovered a connection between women with high levels ... infertility. Although doctors have theorized about the role stress ... study to provide scientific support. , “Stress, if very ... Dr. Larry Barmat, an OB/GYN who specializes in reproductive ...
(Date:7/14/2014)... Philadelphia, PA (PRWEB) July 14, 2014 ... and software solutions to healthcare problems have been ... ’s first Digital Health Accelerator (DHA). , ... 69 applicants via a multi-stage process. They include ... and two overseas companies—Keosys (from France) and Pulse ...
(Date:7/14/2014)... Royal Academy, senescent is he who "begins to age". ... only is senescence not a synonym of ageing, it ... senescence is such a badly named physiological process that ... needs another name. That is the case of Manuel ... one of the world,s leading experts on senescence, who ...
Breaking Medicine News(10 mins):Health News:'Noisy' memory in schizophrenia 2Health News:Bothered by hot flashes? Acupuncture might be the answer 2Health News:Abington Health Physician Addresses Link Between Stress and Infertility 2Health News:Abington Health Physician Addresses Link Between Stress and Infertility 3Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 2Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 3Health News:Seven Healthcare Startups Selected to Participate in University City Science Center’s First Digital Health Accelerator 4Health News:Manuel Serrano proposes a new vision of a process wrongly associated with ageing 2Health News:Manuel Serrano proposes a new vision of a process wrongly associated with ageing 3
... have identified two genes believed to play a role in ... to better diagnosis and treatment of this increasingly common form ... or womb cancer, is the most common malignant cancer of ... of cases being detected has increased markedly, as has mortality. ...
... While studying an HIV protein that plays an essential ... Pittsburgh School of Medicine have discovered compounds that show ... drug discovery efforts have met with little success in ... factor, called Nef, because it lacks biochemical activity that ...
... how your eyes adjust during a blackout? When we go ... must quickly adjust. Vision scientists at Washington University School of ... allows the human eye to adapt to darkness very quickly. ... bright light. The discovery could contribute to better understanding ...
... treatments instead, study finds, , TUESDAY, Oct. 13 (HealthDay News) ... cancer are not turning to mastectomy as their first choice ... as lumpectomy, a new survey has found. , The survey, ... of the American Medical Association , also found that U.S. ...
... ... Support for the Nationwide Health Information Network. , ... Chantilly, VA (PRWEB) October 13, 2009 -- Agilex Technologies, Inc. , ... and public sectors , today announced the appointment of Melissa Chapman to the ...
... fastest-growing retailer of authentic nonfat frozen yogurt, announced it ... , to celebrate the favorite food of the fall ... Spice frozen yogurt, available at all Red Mango ... 13, through December 31, 2009. , (Photo: ...
Cached Medicine News:Health News:Genes behind increasingly common form of cancer identified 2Health News:Pitt researchers find candidates for new HIV drugs 2Health News:Researchers discover mechanism that helps humans see in bright and low light 2Health News:Researchers discover mechanism that helps humans see in bright and low light 3Health News:Mastectomy Not First Choice for Most Breast Cancer Patients 2Health News:Mastectomy Not First Choice for Most Breast Cancer Patients 3Health News:Agilex Technologies Hires Former HHS CIO Melissa Chapman to Lead Health Technology Programs 2Health News:Agilex Technologies Hires Former HHS CIO Melissa Chapman to Lead Health Technology Programs 3Health News:Discover Red Mango's New Seasonal Flavor: Pumpkin Spice 2
(Date:7/14/2014)... July 14, 2014  More than any other generation, Millennials ... tablet computers -- but their eyes don,t. These mobile devices ... before, and the eye has not evolved to cope with ... eyes can do comfortably often results in tired eyes, focusing ... Digital Eye Strain. Now ZEISS has invented a new type ...
(Date:7/14/2014)... , July 14, 2014  Diomics, Inc., ... today announced that the United States Patent and ... by Diomics covering novel biologic sample collection materials, ... use in forensics and diagnostics. ... is by swabbing. Recovery of DNA from a ...
(Date:7/14/2014)... Sinovac Biotech Ltd. (NASDAQ: SVA ), a leading ... that it will hold its 2014 Annual Meeting of Shareholders on Wednesday, ... held at No. 39 Shangdi Xi Road, Haidian District, Beijing ... will be eligible to vote and are invited to attend. ... Weidong Yin , Yuk Lam Lo , Simon Anderson ...
Breaking Medicine Technology:New Eyeglass Lens Helps Our Eyes Keep Up with our Digital Lives 2New Eyeglass Lens Helps Our Eyes Keep Up with our Digital Lives 3Diomics Announces Issuance Of U.S. Patents For Novel Biologic Sample DNA Collection Materials For Use In Forensics And Diagnostics 2Sinovac Schedules 2014 Annual Meeting of Shareholders 2Sinovac Schedules 2014 Annual Meeting of Shareholders 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: