Navigation Links
Penn researchers discover new target for preventing and treating flu
Date:1/30/2008

PHILADELPHIA - Emerging subtypes of influenza A virus hold the potential to initiate a world-wide epidemic in the next few years, according to World Health Organization officials. However, almost all type A influenza viral strains have become resistant to amantadine and rimantadine, two drugs that make up one of only two classes used to treat the flu.

Researchers at the University of Pennsylvania School of Medicine have now provided a new strategy for designing drugs that target the resistant viral strains by solving the three-dimensional structure of a viral protein called the M2 proton channel. This protein is the molecular receptor for these drugs. This study is published in the Jan. 31 issue of the journal Nature.

The M2 protein is located in the viral envelope, forming a long, narrow channel that allows the flow of protons into the viral interior, an essential step for infection. Amantadine sits in this channel and blocks the flow of protons, thus halting infection. In non-resistant viruses, amantadine acts like a cork lodged deep in the channel.

We know that resistance to amantadine is caused by a mutation in the virus M2 protein, but we did not know how this mutation caused resistance, explains senior author William F. DeGrado, PhD, Professor of Biochemistry and Biophysics. Now we do the mutation changes the shape of the channel so amantadine can no longer do its job."

The structure revealed that there is a pocket in the channel next to the location where amantadine fits that is conserved in all influenza A viruses. This newly discovered space could be the target for new drugs. "Inhibitors that target this cavity adjacent to two highly conserved amino acids in M2 might reclaim the M2-blocking class of drugs so that ongoing endemic outbreaks and future pandemics of this deadly virus might be prevented and treated," says DeGrado.

"The crystal structures of influenza M2 with and without the anti-influen
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Researchers investigate links between prostate, cadmium, zinc
2. New nanotube findings by Stanford researchers give boost to potential biomedical applications
3. Researchers Map Paths Governing Neuron Function
4. Cold Spring Harbor Laboratory researchers race against time to save Tasmanian devils
5. Researchers at Peoria Pulmonary Associates to study airway bypass procedure for emphysema
6. Pain medicine meeting unites top researchers and clinicians
7. Researchers identify brains eureka circuitry
8. Researchers find relief for chronic pain
9. Researchers propose consumers buy yearly drug licenses as new way to pay for prescriptions
10. Pros, cons of drug proven to prevent prostate cancer should be considered, researchers recommend
11. DOE awards supercomputing time to UCSD, SDSC researchers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn researchers discover new target for preventing and treating flu
(Date:12/25/2014)... Recently, iFitDress.com, the popular online supplier of wedding ... new selection of black one-shoulder cocktail dresses . In ... are available at discounted prices, up to 70% off. ... for three weeks only. You know, we have thousands of ... in our new items can visit our website for more ...
(Date:12/25/2014)... 2014 The short film “Color of Honor” ... honor of a true 9/11 hero, Welles Remy Crowther. It ... the 24 hours of Nuremberg International Short Film Festival and ... Actress, screenwriter and director Luciana Lagana plays the ... with her husband, Gregory Graham - Graham plays ...
(Date:12/25/2014)... BambooFlooringChina.com sells many bamboo products and the business ... company announces big discounts on its bamboo mats ... BambooFlooringChina.com is the world’s leader in bamboo flooring. According ... Jan. 20, 2015. , The bamboo mats are made ... thread. All the bamboo strips for the mats are ...
(Date:12/25/2014)... Miami, FL (PRWEB) December 25, 2014 When ... often find themselves in a frenzy to get rid of ... classroom. But families in Coral Gables now have the solution ... its second salon clinic location, Lice Troopers provides full spectrum ... in the Coral Gable area, including Sunset, Key Biscayne, Brickell, ...
(Date:12/25/2014)... HealthDay Reporter WEDNESDAY, Dec. 24, 2014 (HealthDay ... receive effective, less expensive care from a clinic that functions ... of dedicated health care professionals, a new study shows. ... either hospitalization or a trip to the emergency room when ... the University of Texas in Houston versus usual care, according ...
Breaking Medicine News(10 mins):Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3
... In this News Digest:, Summary of a study being published ... finding that close relatives of women who carry mutations in ... genetic mutations -- do not have an increased risk of developing ... do not have such mutations. These results run counter to a ...
... , MONDAY, Oct. 31 (HealthDay News) -- People with ... disabled and less likely to return home than stroke patients ... looked at 702 people who had dementia at the time ... had a stroke. The stroke patients with pre-existing dementia ...
... - An unprecedented decade of economic demise and a population ... putting Michigan in a precarious spot: More aging residents needing ... Add in a steady decline in elderly support ratio ... and the situation becomes more dire. But with the help ...
... Men with prostate cancer are twice as likely to commit ... words may reduce this risk, reveals research at the Sahlgrenska ... a study at the University of Gothenburg,s Sahlgrenska Academy, researchers ... surgery for prostate cancer. The suicide rate in this group ...
... Oct. 31 (HealthDay News) --,The longer they live in the ... will develop health problems, a new study says. Researchers ... Examination Survey and discovered a dramatic increase in obesity, diabetes ... the United States for more than 20 years. Compared ...
... liberal in their advice to patients on alcohol consumption. ... while men who are heavy drinkers get to continue ... a thesis from the Sahlgrenska Academy at the University ... Gothenburg,s Sahlgrenska Academy have for the first time looked ...
Cached Medicine News:Health News:Study shows no increased risk of breast cancer for non-carriers in families with BRCA gene mutation 2Health News:Study shows no increased risk of breast cancer for non-carriers in families with BRCA gene mutation 3Health News:Dementia May Impede Stroke Recovery 2Health News:Michigan State University tackles health needs of an aging statewide population 2Health News:New findings could lower risk of suicide in men with prostate cancer 2Health News:Life in U.S. Not Always a Plus for Immigrants' Health 2Health News:Doctors' own alcohol consumption colors advice to patients 2
(Date:12/22/2014)... Dec. 22, 2014 NxStage Medical, Inc. (NASDAQ: ... innovative dialysis products, announced today that the U.S. ... System One™ to perform hemodialysis overnight while the ... nocturnal hemodialysis. NxStage,s® System One is the first ... for this indication. Home nocturnal ...
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... of the "US Self-monitoring Blood Glucose Market" ... http://photos.prnewswire.com/prnh/20130307/600769 This market insight focuses on ... the United States . Reimbursement analysis ... Thorough product analyses for more than 73 SMBG meters ...
(Date:12/22/2014)... 2014 Research and Markets ( ... "Investment Analysis of the US Medical Device ... http://photos.prnewswire.com/prnh/20130307/600769 ... device sector identifies the key trends and rationale ... and mergers and acquisitions. The study ...
Breaking Medicine Technology:NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3US Self-monitoring Blood Glucose Market 2Investment Analysis of the US Medical Device Sector 2
... 4 Phosphagenics,Limited (ASX: POH, AIM: PSG, OTCQX: ... will jointly commence a phase 2 human clinical,trial ... Phospha E(R),in the management of metabolic syndrome. ... double-blind phase 2,clinical trial, which will commence shortly. ...
... Ore., Oct. 3 Virogenomics, Inc. today,announced that ... grant from the,National Institute of Standards and Technology ... that tests for many different biological markers in,a ... could revolutionize research on and,the diagnosis of multifactorial ...
Cached Medicine Technology:Nestle Nutrition and Phosphagenics to Commence Phospha E(R) Phase 2 Clinical Trial 2Nestle Nutrition and Phosphagenics to Commence Phospha E(R) Phase 2 Clinical Trial 3Nestle Nutrition and Phosphagenics to Commence Phospha E(R) Phase 2 Clinical Trial 4Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors 2Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors 3Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors 4
A highly precise stereotactic radiosurgery system for the treatment of intra-cranial lesions....
The Primus linear accelerator is a fully digital, technologically advanced radiation therapy treatment delivery system. It can be configured for delivery of routine, 3-D conformal or IMRT treatments....
... The cost-effective, proven and reliable ... rates for rapid patient treatment, fastest ... flatness - less than 500 milliseconds, ... highest beam stability, greatest number of ...
The Clinac 2100 C/D family of accelerators are reliable, easy-to-use, flexible and cost-effective systems....
Medicine Products: