Navigation Links
Penn-led research suggests a new strategy to prevent or halt periodontal disease
Date:12/7/2012

PHILADELPHIA Periodontitis, a form of chronic gum disease that affects nearly half of the U.S. adult population, results when the bacterial community in the mouth becomes unbalanced, leading to inflammation and eventually bone loss. In its most severe form, which affects 8.5 percent of U.S. adults, periodontitis can impact systemic health.

By blocking a molecular receptor that bacteria normally target to cause the disease, scientists from the University of Pennsylvania have now demonstrated an ability in a mouse model to both prevent periodontitis from developing and halt the progression of the disease once it has already developed.

The study, published in the Journal of Immunology, was led by Toshiharu Abe, a postdoctoral researcher in the Department of Microbiology in Penn's School of Dental Medicine. Abe works in the lab of George Hajishengallis, a professor in the department who was a senior author on the paper. The co-senior author was John D. Lambris, the Dr. Ralph and Sallie Weaver Professor of Research Medicine in the Department of Pathology and Laboratory Medicine in Penn's Perelman School of Medicine. Kavita B. Hosur and Evlambia Hajishengallis from Penn Dental Medicine also contributed to the research, as did Penn Medicine's Edimara S. Reis and Daniel Ricklin.

In previous research, Hajishengallis, Lambris and colleagues showed that Porphyromonas gingivalis, the bacterium responsible for many cases of periodontitis, acts to "hijack" a receptor on white blood cells called C5aR. The receptor is part of the complement system, a component of the immune system that helps clear infection but can trigger damaging inflammation if improperly controlled.

By hijacking C5aR, P. gingivalis subverts the complement system and handicaps immune cells, rendering them less able to clear infection from the gum tissue. As a result, numbers of P. gingivalis and other microbes rise and create severe inflammation. According to a
'/>"/>

Contact: Katherine Unger Baillie
kbaillie@upenn.edu
215-898-9194
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. LSUHSC research finding keys to future obesity & related diseases
2. Speech-language researcher awarded top honors
3. Mitchell Vazquez Gives Away Donations to Advance Cancer Research Cause
4. Researchers craft tool to minimize threat of endocrine disruptors in new chemicals
5. Researchers discover regulator linking exercise to bigger, stronger muscles
6. Prenatal tests more informative using microarray technology, find GW researchers
7. Environmental Monitoring in China Industry Research Report – Now Available from IBISWorld
8. Akron researchers devise Rx for ailing wellness programs
9. USC Norris cancer research ranks among top clinical advances for 2012
10. Case Western Reserve School of Medicine receives funding for healthy growth research
11. Studying marrow, URMC researchers accelerate blood stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... The aftermath of the November 24th hack on Sony ... Hollywood, but worldwide. As reported in the Los ... attack are starting a finger-pointing game which could put some ... are not the only ones affected, regular employees who had ... times ahead, agents and lawyers could be in for some ...
(Date:12/20/2014)... AZ (PRWEB) December 20, 2014 Parker ... professional technicians with years of experience in contractor services ... dedicated contractor services for the homeowners of Arizona. Parker ... team a professional contractor technicians that make customer service ... 1974 in Phoenix Arizona and started with one service ...
(Date:12/19/2014)... Sub Zero Ice Cream is partnering up with the ... 28th from 2pm-6pm at the Expo Center on the northeast ... , Inquiries regarding time slots and signing up, email todd.subzeroicecream(at)gmail(dot)com. ... process, Sub Zero Ice Cream & Yogurt will be offering ... About Sub Zero Ice Cream & Yogurt , Sub ...
(Date:12/19/2014)... Eufaula, Oklahoma, located just 9 miles ... state’s largest lake with more than 600 miles of ... a little more than 3,000 residents, hosted its annual ... 6th of December. , Featuring Santa, Christmas lights and ... on Main Street. Narconon Arrowhead’s parade float participated ...
(Date:12/19/2014)... FRIDAY, Dec. 19, 2014 (HealthDay News) -- New research warns parents ... young lives at risk. Nearly half of teen drivers killed ... that were at least 11 years old and often lacked important ... Eighty-two percent of teen drivers killed in crashes were in ... six to 10 years old, 31 percent were in cars 11 ...
Breaking Medicine News(10 mins):Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 2Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 3Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 4Health News:Sony Pictures Hack Perfect Example of the Reach a Single Cyber Attack Can Have 5Health News:Parker & Sons Announces Reaching A Milestone By Providing 40 Years Of Dedicated Contractor Services For Homeowners Of Arizona 2Health News:Parker & Sons Announces Reaching A Milestone By Providing 40 Years Of Dedicated Contractor Services For Homeowners Of Arizona 3Health News:Shark Tank’s Sub Zero Ice Cream Sponsors Blood Drive 2Health News:Narconon Arrowhead Debuts Float at Checotah and Eufaula Christmas Parades 2Health News:Narconon Arrowhead Debuts Float at Checotah and Eufaula Christmas Parades 3Health News:Older Cars a Bad Choice for Younger Drivers 2
... , New Rochelle, NY, September 1, 2011Scientists involved in ... issues: the creation of effective delivery systems and the ... & Biotechnology News (GEN). Top investigators in the field ... in San Diego entitled "DNA Vaccines: Building on Clinical ...
... children need to get a seasonal flu vaccination this year, even ... says. The 2011-12 flu vaccine protects against the same three ... by as much as 50 percent 6 to 12 months after ... flu shot this year, according to the AAP. The group ...
... , THURSDAY, Sept.1 (HealthDay News) --,Molecular signals from ... in mice, a finding that may lead to new treatments ... get these fat cells in the skin to talk to ... follicles, we might be able to get hair to grow ...
... Sex hormones strongly influence people,s interests, which affect ... psychologists. , "Our results provide strong support for ... working with things versus people," said Adriene M. ... A. Berenbaum, professor of psychology and pediatrics, Penn ...
... , THURSDAY, Sept. 1 (HealthDay News) -- The intensity of ... improving your chances of living a longer life, a new ... found that men with high levels of cycling intensity lived ... years longer, than men with low intensity. Among female ...
... A natural yellowing of the eye lens that absorbs blue light ... volunteers, according to a,study in the September 1 issue of the ... with age, so did the risk of insomnia. "The strong ... disorders become more frequent with increasing age," said Line Kessel, M.D., ...
Cached Medicine News:Health News:GEN reports on advances in DNA vaccine delivery and production 2Health News:Last Year's Flu Shot Won't Protect Kids This Season 2Health News:Mouse Study Could Give New Clues to Fighting Baldness 2Health News:Sex hormones impact career choices 2Health News:Aging eyes linked to sleepless nights, new study shows 2
(Date:12/19/2014)... 2014 You,re visiting the dentist for what ... he or she says you need a root canal. ... may have several questions and feel apprehensive about your ... it,s nothing to worry about. The Pennsylvania Dental Association ... any anxiety the public may have surrounding this common ...
(Date:12/19/2014)...   Hospira, Inc. (NYSE: HSP ... infusion technologies, today announced that the company will present ... Wednesday, Jan. 14, 2015, in San Francisco.  ... 10:30 a.m. Pacific time on Wednesday, Jan. 14, 2015.  ... a live audiocast accessible via the Investor Relations section ...
(Date:12/19/2014)... , Dec. 19, 2014  Monarch America Inc. ... Kinetics Corp.) is pleased to provide this review of ... growth in 2015. "Over this past year, ... and I am extremely proud to say that Monarch ... today than it has ever been," stated Eric ...
Breaking Medicine Technology:Root Canals Have Become More Routine 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3
... 19, 2012  Sunpeaks Ventures, Inc. (OTC Bulletin ... or "Sunpeaks Ventures") and its wholly owned subsidiary Healthcare ... Clotamin ® is now available on Walgreens.com.    ... step for the distribution of Clotamin.  Clotamin has a ...
... March 19, 2012  New pain medicine and prescription ... Self-Referral Act, can lead to steep penalties and ... advisors with clients in Florida need a clear ... requirements for a statewide prescription drug monitoring database; ...
Cached Medicine Technology:Sunpeaks Ventures Announces Clotamin available on Walgreens.com 2Navigating New Pain Medicine and Prescription Drug Laws in the Sunshine State 2Navigating New Pain Medicine and Prescription Drug Laws in the Sunshine State 3Navigating New Pain Medicine and Prescription Drug Laws in the Sunshine State 4
... Every Bard® Biopsy Instrument and Needle ... one important goal: a large quality, reliable ... exceptional performance, featuring ultra-sharp tips and polished ... broad selection of biopsy systems and needle ...
... Used to obtain multiple core biopsies ... biopsy needle is designed to fit ... micro-sharpening process that produces an ultrasharp ... histological cores. Uni-Cor™ has an etched ...
... offers a customized approach to performing ... associated with current stranded products as ... seed and spacer implant techniques.SourceLink™ Connectors ... quantity and seed activity level (in ...
... is designed to bring efficiency and quality ... combines the superior technology of fluorescent flow ... Continuous sampling or batch processing are ... sample processing in high volume laboratories. ...
Medicine Products: