Navigation Links
Penn collaborates on $8 million Barrett's esophagus research network
Date:11/3/2011

d bile acids in the upregulation of molecular pathways and stem/progenitor cells, and possible ways to target these cells for developing preventive and therapeutic treatments.

The Penn project members will bring to the network a large patient population and Barrett's inflammatory animal models. Three main projects comprise the network's goals:

  • Identify the role of Notch signaling proteins in animal models of Barrett's esophagus to determine the effects of Notch inhibition or Notch activation on progression to cancer.
  • Characterize the stem/progenitor cell of origin in Barrett's esophagus in mouse models. A pilot clinical trial using an antagonist of a G-protein coupled receptor expressed on stem/progenitor cells upregulated in the disease will be conducted to determine if regression of Barrett's esophagus occurs.
  • Identify novel biomarkers and gene signatures in Barrett's esophagus, correlating data sets from animal and human models to clarify which cells play the most important role in disease progression. A cohort of patients undergoing radiofrequency ablation for Barrett's esophagus will be assembled to identify biomarkers of response to therapy and to study the development of BE.

"Our novel preclinical models serve as the foundation for testing hypotheses, which are then brought ultimately to the clinic in a true translational 'bench-to-bedside' approach through biomarker, chemoprevention and therapeutic studies," says Rustgi.

The other subtype of esophageal cancer is esophageal squamous cell carcinoma (ESCC), which is common worldwide. Penn investigators have a long-standing NCI-funded program project in this cancer, dating to 2003, funded to nearly $10 million every five years. This group's Principal Investigator is also Dr. Rustgi; other investigators include Penn researchers Dr. J. Alan Diehl, professor of Cancer Biology and director of cancer cell biology in the Abramson Family Cancer Research Ins
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Philips Collaborates with Microsoft to Enhance Healthcare Efficiencies and Productivity
2. Eisner USA, LLC Collaborates with Surgical Review Corp to Provide Innovative Bariatric Devices to Bariatric Surgery Center of Excellence (BSCOE) Participants
3. PeopleStreme Collaborates with SkillSoft for Learning Management Content
4. UCSF collaborates with Zcube to develop new ways to deliver drugs
5. Childrens National collaborates with NIH researchers to identify gene variant in Proteus syndrome
6. Amway One by One Campaign for Children Reaches 7 Million Kids
7. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
8. International Diabetes Federation awards $2 million to 9 global diabetes research projects
9. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
10. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
11. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... 2014 This September, California Library ... Library, celebrates 30 years of changing the lives ... inception, California’s Library Literacy Services has helped nearly ... read and write. , To mark the 30th ... is launching a month-long awareness campaign titled “Together, ...
(Date:8/31/2014)... August 2014: Renal denervation seems to be more successful ... when it includes accessory renal arteries, according to research ... from Germany. , Dr Schmiedel said: "More than one ... defined as blood pressure (BP) greater than 140/90 mmHg. ... (rHTN) and are unable to reduce BP below 140/90 ...
(Date:8/30/2014)... A new method to predict the optimal number ... at ESC Congress today by Dr Benjamin Dahan from ... AEDs located in public places for optimal prevention of ... said: "Out of hospital cardiac arrest is a major ... 50 and 100 per 100 000 in the general ...
(Date:8/30/2014)... Walking-Canes.Net has released several articles related ... can help in making gait problems easier. The new ... website that contains all of the news articles that were ... articles deal with diseases that make walking a problem and ... help in making life easier for the patient. The articles ...
(Date:8/30/2014)... As the economy continues to recover and ... bathrooms and in-home fitness centers, the North American ... interest not only in designing and installing saunas but ... of sauna. Through working with manufacturers across North ... Society provides a strong knowledge base of Finnish traditions ...
Breaking Medicine News(10 mins):Health News:California Library Literacy Services Celebrates 30th Anniversary 2Health News:California Library Literacy Services Celebrates 30th Anniversary 3Health News:Renal denervation more successful when it includes accessory arteries 2Health News:New method predicts optimal number and location of AEDs 2Health News:Information Articles on Gait Problems from Walking-Canes.Net 2Health News:As Interest in Saunas Increases, the North American Sauna Society Increases Outreach to Provide Education on History, Design, and Culture 2
... , , Consumers Must Have Full ... by Congress , , WASHINGTON, Sept. 22 ... the National Association of Professional Insurance Agents (PIA) is again reminding ... of licensed, professional, independent insurance agents in any reform plan devised ...
... SAN DIEGO, Sept. 22 US Farms, Inc. (Pink Sheets: ... Inc., a Southern California based branding and interactive marketing firm to assist ... consumer brand product line, Aloe365. , , Yan ... are now in a full blown sales and marketing effort with our ...
... 22 /PRNewswire-Asia/ -- The Yanda International Health,City is set to ... The environmentally friendly complex will include facilities offering,state-of-the-art care for ... medical research and training facilities. It,will also include an international ... a model in healthcare services in the 21st century. It ...
... , , , ... rates of childhood obesity and related diseases could mean the next generation ... their parents, NFL Network today kicked off the second year of ... on Manhattan,s Lower East Side. As part of the league,s NFL ...
... NEW YORK, Sept. 22 Reportlinker.com announces that a ... , U.S. Equine Market: Feed, Health Care ... http://www.reportlinker.com/p0148037/US-Equine-Market-Feed-Health-Care-and-Services-for-Horses-The.html , , ... States, which are used primarily for recreation and entertainment. These horses ...
... , , DUBLIN, ... an expanded suite of consulting, analytics and operations services to ... patient safety. , , These ... their hospitals address ongoing economic constraints, improve quality outcomes and ...
Cached Medicine News:Health News:Healthcare Reform Must Include Full Participation by Licensed Professional Insurance Agents 2Health News:US Farms, Inc. Announces Agreement With Rage Marketing, Inc. to Increase Brand Awareness and E-Commerce Product Sales 2Health News:US Farms, Inc. Announces Agreement With Rage Marketing, Inc. to Increase Brand Awareness and E-Commerce Product Sales 3Health News:Yanda International Health City - World Class Healthcare in China 2Health News:Yanda International Health City - World Class Healthcare in China 3Health News:NFL Network Launches 2009 National Keep Gym in School Campaign at New York City Middle School; Effort Will Give More U.S. Students Access to Quality Physical Education 2Health News:NFL Network Launches 2009 National Keep Gym in School Campaign at New York City Middle School; Effort Will Give More U.S. Students Access to Quality Physical Education 3Health News:NFL Network Launches 2009 National Keep Gym in School Campaign at New York City Middle School; Effort Will Give More U.S. Students Access to Quality Physical Education 4Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 2Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 3Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 4Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 5Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 6Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 7Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 8Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 9Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 10Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 11Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 12Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 13Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 14Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 15Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 16Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 17Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 18Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 19Health News:Reportlinker Adds U.S. Equine Market: Feed, Health Care and Services for Horses, The Report 20Health News:Cardinal Health Introduces Expanded Suite of Services to Help Hospital Pharmacies Improve Cost Containment, Workflow, Patient Safety 2Health News:Cardinal Health Introduces Expanded Suite of Services to Help Hospital Pharmacies Improve Cost Containment, Workflow, Patient Safety 3Health News:Cardinal Health Introduces Expanded Suite of Services to Help Hospital Pharmacies Improve Cost Containment, Workflow, Patient Safety 4
(Date:8/29/2014)... , Aug. 29, 2014 Research ... "Global Multiple Sclerosis Drugs Market 2014-2018" report ... a chronic, inflammatory medical condition that results in demyelination, ... because of an abnormal response by the immune system, ... It is a potentially debilitating disease in which the ...
(Date:8/29/2014)... MENLO PARK, Calif. , Aug. 29, ... (OTCQB: DMPI) ("DelMar" "the Company") today announced the filing ... Company recently changed its fiscal year end to June ... its common stock on a national securities exchange in ... as filed with the United States Securities Exchange Commission ...
(Date:8/29/2014)... ANDOVER, Mass. , Aug. ...  (NYSE: PHG ... at the  European Society of ... company is highlighting the full range of its cardiology solutions ... the care continuum from prevention and ...
Breaking Medicine Technology:Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 2DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 3DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 4DelMar Pharmaceuticals Fiscal 2014 Year End Results and Summary of Recent Developments 5Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 2Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 3Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 4Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 5
... Life Spine, a medical device company that designs, ... of spine disorders, announced that on Saturday, April 2, ... Technology Training. Over twenty surgical participants ... hands-on cadaver lab training on the safe and effective ...
... Smith & Nephew,s (NYSE: SNN ; ... System, an operative hysteroscopy device for the removal of ... milestone. The TRUCLEAR System is a first-of-its ... hysteroscope with minimally invasive tissue removal capabilities, allowing a ...
Cached Medicine Technology:Smith & Nephew's TRUCLEAR System: A Gold Standard for Removal of Intrauterine Polyps and Fibroids 2Smith & Nephew's TRUCLEAR System: A Gold Standard for Removal of Intrauterine Polyps and Fibroids 3Smith & Nephew's TRUCLEAR System: A Gold Standard for Removal of Intrauterine Polyps and Fibroids 4
Weitlaner retractor, blunt....
Halle bone curette, 8 1/4, oval, malleable shaft, 4 mm wide....
Bruns (Volkmann) bone curette, with Novotex plastic handle (autoclavable in autoclave up to 143C by 3 bar), 9, oval....
Ring curette, 4 mm 90 angle....
Medicine Products: