Navigation Links
Penn collaborates on $8 million Barrett's esophagus research network
Date:11/3/2011

PHILADELPHIA - A research group at the Perelman School of Medicine of the University of Pennsylvania, led by John Lynch, MD, PhD, assistant professor of Medicine in the Division of Gastroenterology, has received a National Cancer Institute (NCI) grant to establish a Barrett's esophagus translational research network (BETRNet) with Columbia University (led by Dr. Timothy Wang) and the Mayo Clinic (led by Dr. Kenneth Wang). The award is for nearly $8 million across all sites.

Barrett's esophagus (BE) is an increasingly prevalent, pre-cancerous disorder that results primarily from reflux of acid and bile. It afflicts millions of Americans and is a precursor to esophageal adenocarcinoma (EAC), which has the fastest rate of increase of any cancer in the US.

Co- principal investigators are Lynch, Gary Falk, MD, professor of Medicine; Greg Ginsberg, MD, professor of Medicine and director of endoscopy; Antonia Sepulveda, MD, PhD, professor of Pathology and Laboratory Medicine, and Anil K. Rustgi, MD, T. Grier Miller professor of Medicine and chief of the Division of Gastroenterology. Drs. Rustgi, Timothy Wang and Kenneth Wang direct the BETRNet's coordination with two other funded institutions -- the University of Michigan as and Case Western Reserve University -- in conjunction with the NCI and Vanderbilt University (coordinating center).

"We are all very excited to be a part of this multicenter research network," says Lynch. "Our understanding of the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma has lagged behind that of other cancers because we have not yet developed physiologically relevant laboratory models and an integrated research network, both of which are supported by this award."

The award provides for a multidisciplinary, translational research program to study the origins and pathogenesis of the disorder. The team, which has collaborated in the past, will focus on the role of chronic inflammation and bile acids in the upregulation of molecular pathways and stem/progenitor cells, and possible ways to target these cells for developing preventive and therapeutic treatments.

The Penn project members will bring to the network a large patient population and Barrett's inflammatory animal models. Three main projects comprise the network's goals:

  • Identify the role of Notch signaling proteins in animal models of Barrett's esophagus to determine the effects of Notch inhibition or Notch activation on progression to cancer.
  • Characterize the stem/progenitor cell of origin in Barrett's esophagus in mouse models. A pilot clinical trial using an antagonist of a G-protein coupled receptor expressed on stem/progenitor cells upregulated in the disease will be conducted to determine if regression of Barrett's esophagus occurs.
  • Identify novel biomarkers and gene signatures in Barrett's esophagus, correlating data sets from animal and human models to clarify which cells play the most important role in disease progression. A cohort of patients undergoing radiofrequency ablation for Barrett's esophagus will be assembled to identify biomarkers of response to therapy and to study the development of BE.

"Our novel preclinical models serve as the foundation for testing hypotheses, which are then brought ultimately to the clinic in a true translational 'bench-to-bedside' approach through biomarker, chemoprevention and therapeutic studies," says Rustgi.

The other subtype of esophageal cancer is esophageal squamous cell carcinoma (ESCC), which is common worldwide. Penn investigators have a long-standing NCI-funded program project in this cancer, dating to 2003, funded to nearly $10 million every five years. This group's Principal Investigator is also Dr. Rustgi; other investigators include Penn researchers Dr. J. Alan Diehl, professor of Cancer Biology and director of cancer cell biology in the Abramson Family Cancer Research Institute; Dr. Hiroshi Nakagawa, research associate professor of Medicine; Dr. Phyllis Gimotty, professor of Biostatistics; Dr. Jonathan Katz, assistant professor of Medicine; Dr. Gary Wu, professor of medicine; and Dr. Sunil Singal, assistant professor of Surgery, as well as Dr. Meenhard Herlyn, professor at the Wistar Institute and Dr. Andres Klein-Szanto at Fox Chase Cancer Center, collaborating with groups at Massachusetts General Hospital and Dana Farber Cancer Institute.


'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Philips Collaborates with Microsoft to Enhance Healthcare Efficiencies and Productivity
2. Eisner USA, LLC Collaborates with Surgical Review Corp to Provide Innovative Bariatric Devices to Bariatric Surgery Center of Excellence (BSCOE) Participants
3. PeopleStreme Collaborates with SkillSoft for Learning Management Content
4. UCSF collaborates with Zcube to develop new ways to deliver drugs
5. Childrens National collaborates with NIH researchers to identify gene variant in Proteus syndrome
6. Amway One by One Campaign for Children Reaches 7 Million Kids
7. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
8. International Diabetes Federation awards $2 million to 9 global diabetes research projects
9. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
10. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
11. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... 17, 2017 , ... Metro Development Group has broken ground ... technology into the fabric of an entire community. A highlight of this new ... in a yet-to-be-named, health focused campus. Leading this initiative in partnership with Metro ...
(Date:1/17/2017)... ... January 17, 2017 , ... Peoples Health is pleased to ... on Dec. 1, 2016. Peoples Health, a Metairie-based Medicare Advantage company, serves more ... addition to our provider network, and the addition will benefit our members in ...
(Date:1/17/2017)... ... January 17, 2017 , ... Neil H. Greco Insurance Agency, ... to communities throughout the region, is launching a charity drive to raise awareness of ... far the deadliest killer in America, and is responsible for 1 in every 4 ...
(Date:1/17/2017)... ... January 17, 2017 , ... Seceon , the only ... real-time, today announced a strategic partnership with TechLab Security, a leading ... partners, TechLab Security has become a strategic partner and a value added reseller ...
(Date:1/17/2017)... , ... January 17, 2017 , ... Many people make New Year’s resolutions or renew ... Mondavi is making it easier for people who want to kick off 2017 with ... and existing patients. , These special offers include: , , ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... , Jan. 17, 2017  From the company that brought a ... fourteen years ago, comes a new line of companion animal pet ... world leader in equine first aid, has developed two sizes of ... USA , Inc. Featuring a small and a ... company and rodeo family, is not a newcomer to working with ...
(Date:1/17/2017)... , Jan. 17, 2017  OrthoAccel ® ... Orthodontics (JCO) has published "The Effect of Vibration ... patients. Conducted by Dr. S. Jay Bowman , ... Class II malocclusions, AcceleDent,s SoftPulse Technology ® speeds ... while also reducing the number of days to move ...
(Date:1/17/2017)... Research and Markets has announced the addition ... report to their offering. ... The global fluoropolymer market in the healthcare industry to ... Global Fluoropolymer Market in the Healthcare Industry 2016-2020, has ... industry experts. The report covers the market landscape and its growth ...
Breaking Medicine Technology: