Navigation Links
Penn animal study identifies new DNA weapon against avian flu
Date:7/1/2008

stem into mounting a broad response against pandemic flu, including strains to which the immune system was never exposed. Antibodies induced by the vaccine rapidly reached protective levels in all three animal species.

"The synthetic DNA vaccines designed in this study customize the antigen to induce more broad immune responses against the pathogen," says Weiner.

Researchers found evidence of two types of immune responses T lymphocytes and antibodies -- in all three types of animal models. Two types of animal models (mice and ferrets) were protected from both disease and mortality when exposed to avian flu.

To ensure increased DNA delivery, the researchers administered the vaccine in combination with electroporation, a small, harmless electric charge that opens up cell pores facilitating increased entry of the DNA vaccine into cells.

If proven in humans, this research could lead the way to preparing against an outbreak of avian flu. Because these synthetic DNA vaccines are effective against multiple cross strains, vaccines could be created, stockpiled, prior to a pandemic, and thus be delivered quickly in the event of an outbreak, surmise the researchers.

This study has shown other advantages of DNA vaccines. On one hand, killed vaccines, which involve the injection of a dead portion of a virus, are relatively safe but usually effective at producing only a strong cellular immunity. Live vaccines, which involve the injection of a form of a live virus, can have increased manufacturing and some safety issues. Both of these vaccine strategies may have concerns in persons with certain allergies (egg for example) as current manufacturing methods rely on egg based production technologies. On the other hand, DNA vaccines preclude the need to create live tissue samples, which presents risk to those working with the virus.

"DNA vaccines have the benefits and avoid many conceptual negatives of other types of traditional
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Newly approved ocular safety methods reduce animal testing
2. Data Published in Plastic and Reconstructive Surgery Show Cohera Medicals Surgical Adhesive, TissuGlu(R), Prevents Seroma Formation in Animal Abdominoplasty Model
3. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow in Indianapolis is Participating
4. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow in Cincinnati is Participating
5. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in Texas Participating
6. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in New Jersey Participating
7. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in Minnesota Participating
8. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in Michigan Participating
9. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in Colorado Participating
10. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in California Participating
11. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2015)... ... July 28, 2015 , ... Dr. Edward Buckingham and ... Sudeep Roy in July 2016. Coming to Austin from Philadelphia, Dr. Roy will ... The twelve-month long training is facilitated annually by the American Academy of Facial Plastic ...
(Date:7/28/2015)... ... July 16, 2015 (PRWEB) July 28, 2015 , ... ... providing Health insurance quotes to its clients, recently announced the launch of Commercial, ... best suits their specific needs. , Liability automobile insurance policies are one ...
(Date:7/28/2015)... ... 28, 2015 , ... Master flutist and solo artist Gary Stroutsos shares his ... in this collection of serene, restorative instrumental music. Tracks carefully curated by White ... body work and more -- to help the listener deeply breathe in a healing ...
(Date:7/28/2015)... (PRWEB) , ... July 28, 2015 , ... BMI of ... now offering the duodenal switch weight loss surgery procedure. Committed to helping ... bariatric surgery procedures, BMI of Texas is one of the first practices ...
(Date:7/28/2015)... (PRWEB) , ... July 28, 2015 , ... ... the SmileCareClub Invisible Aligner System to its online product offerings, giving ... using a teledentistry model and cloud-based technology, SmileCareClub allows patients to get quality, ...
Breaking Medicine News(10 mins):Health News:Buckingham Center for Facial Plastic Surgery Welcomes Fellow 2Health News:Buckingham Center for Facial Plastic Surgery Welcomes Fellow 3Health News:Nations Insurance Solutions Announces Auto, Motorcycle, and Commercial Business Insurance Quotes. 2Health News:Flute Meditations for Yoga & Massage: Calming Spa Music for Relaxation & Sleep by Gary Stroutsos 2Health News:Flute Meditations for Yoga & Massage: Calming Spa Music for Relaxation & Sleep by Gary Stroutsos 3Health News:Flute Meditations for Yoga & Massage: Calming Spa Music for Relaxation & Sleep by Gary Stroutsos 4Health News:BMI of Texas Now Offering Duodenal Switch Surgery – Weight Loss Procedure Helps Obese Patients Lose Weight Quickly 2Health News:BMI of Texas Now Offering Duodenal Switch Surgery – Weight Loss Procedure Helps Obese Patients Lose Weight Quickly 3Health News:Brookstone Now Offers SmileCareClub Teeth Straightening System 2Health News:Brookstone Now Offers SmileCareClub Teeth Straightening System 3
... history helps the Club open its doors to area ... youths on September 28, PORTLAND, ... have a new place to play, learn and grow with,the grand opening of ... $500,000 "Break the Barrier" grant from Regence,the largest in the company,s history. The ...
... is categorized as an eating disorder, it is not known ... that regulate appetite. Now, a new study finds that ... the specific part of the brain that is important for ... of Pittsburgh and University of California, San Diego researchers currently ...
... about efforts to educate, Congress regarding the impact of DRA ... ... 25 AMICAS, Inc. (Nasdaq: AMCS ),a leader in ... it is hosting a DRA education session,featuring Timothy Trysla, executive ...
... Presidential,candidate Senator John Edwards announced yesterday a new ... in the US and,abroad. His plan also includes ... provide reproductive health services., "We in New ... his proposal on funding," said Reverend Paige Blair, ...
... STATION, Sept. 25, 2007 -- Researchers at Texas A&M University ... about: a treatment for influenza that forms a jelly when ... being used to treat bird flu in humans, technically termed ... other uses, such as for the common flu shot, says ...
... What makes an occurrence an interesting case, a scandalous ... of Critical Inquiry, named academes most prestigious theory journal ... the standard unit in law, medicine, psychoanalysis, the ... makes a case ordinary, easily dealt with, or forgettable? ...
Cached Medicine News:Health News:Grand Opening of Regence Boys & Girls Club Marks a Milestone in Historic New Columbia Community Revitalization 2Health News:Grand Opening of Regence Boys & Girls Club Marks a Milestone in Historic New Columbia Community Revitalization 3Health News:Sense of taste different in women with anorexia nervosa 2Health News:AMICAS Hosts Complimentary DRA Education Session Featuring Timothy Trysla 2Health News:Exciting New Plan from John Edwards on AIDS; Plan is 'Bold and Achievable,' say New Hampshire Activists 2Health News: Nosespray vaccine using aloe vera has exciting potential, researcher says 2Health News:'Making the Case:' special double issue of Critical Inquiry 2Health News:'Making the Case:' special double issue of Critical Inquiry 3
(Date:7/28/2015)... 28, 2015  Nevro Corp. (NYSE: NVRO ... providing innovative evidence-based solutions for the treatment of ... SENZA-RCT results in the Online First edition of ... Society of Anesthesiologists. The SENZA-RCT ... the first to directly compare spinal cord stimulation ...
(Date:7/28/2015)... July 28, 2015  SeraCare Life Sciences, a ... announced today at the American Association of Clinical ... licensing agreement with the University of California, San ... (T21), Trisomy 18 (T18) and Trisomy 13 (T13) ... creating "patient-like" reference materials for Non-Invasive Prenatal Testing ...
(Date:7/28/2015)... FORT WORTH, Texas , July 28, 2015 /PRNewswire/ ... Report "Global Dermatology Devices Market by Type (Dermatology Treatment ... MRI, CT), Dermatoscopes, Microscopes]), by Application, by Geography - ... market is expected to reach $11.88 billion by 2019, ... Browse through the TOC of Global Dermatology ...
Breaking Medicine Technology:Nevro Announces Publication of SENZA-RCT Results in Anesthesiology 2SeraCare Life Sciences Signs License Agreement with UCSF and Announces Early Access Program for Development of Aneuploidy Reference Materials 2SeraCare Life Sciences Signs License Agreement with UCSF and Announces Early Access Program for Development of Aneuploidy Reference Materials 3Global Dermatology Devices Market to be Worth $11.88 Billion by 2019 2Global Dermatology Devices Market to be Worth $11.88 Billion by 2019 3
... 3, 2012  Bacterin International Holdings, Inc. (NYSE Amex: ... graft material and antimicrobial coatings for medical applications, today announced ... 2012:  2012 Highlights: , Revenue ... for the first quarter of 2011. , Operating loss ...
... 3, 2012 In the past couple of months, ... of whooping cough and ongoing attention to measles outbreaks ... The Washington State Medical Association (WSMA) is urging adults ... and get the needed booster shots to keep their ...
Cached Medicine Technology:Bacterin Announces First Quarter 2012 Revenue of $7.8 Million, Up 29% Year-over-Year, on Gross Margins of 76%, and 34% Reduction in Operating Loss 2Bacterin Announces First Quarter 2012 Revenue of $7.8 Million, Up 29% Year-over-Year, on Gross Margins of 76%, and 34% Reduction in Operating Loss 3Bacterin Announces First Quarter 2012 Revenue of $7.8 Million, Up 29% Year-over-Year, on Gross Margins of 76%, and 34% Reduction in Operating Loss 4Bacterin Announces First Quarter 2012 Revenue of $7.8 Million, Up 29% Year-over-Year, on Gross Margins of 76%, and 34% Reduction in Operating Loss 5Bacterin Announces First Quarter 2012 Revenue of $7.8 Million, Up 29% Year-over-Year, on Gross Margins of 76%, and 34% Reduction in Operating Loss 6Bacterin Announces First Quarter 2012 Revenue of $7.8 Million, Up 29% Year-over-Year, on Gross Margins of 76%, and 34% Reduction in Operating Loss 7Bacterin Announces First Quarter 2012 Revenue of $7.8 Million, Up 29% Year-over-Year, on Gross Margins of 76%, and 34% Reduction in Operating Loss 8Bacterin Announces First Quarter 2012 Revenue of $7.8 Million, Up 29% Year-over-Year, on Gross Margins of 76%, and 34% Reduction in Operating Loss 9Bacterin Announces First Quarter 2012 Revenue of $7.8 Million, Up 29% Year-over-Year, on Gross Margins of 76%, and 34% Reduction in Operating Loss 10Washington State Medical Association (WSMA) Urges Adults to Get Recommended Immunizations 2Washington State Medical Association (WSMA) Urges Adults to Get Recommended Immunizations 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: