Navigation Links
Penn animal study identifies new DNA weapon against avian flu
Date:7/1/2008

PHILADELPHIA - Researchers at the University of Pennsylvania School of Medicine have identified a potential new way to vaccinate against avian flu. By delivering vaccine via DNA constructed to build antigens against flu, along with a minute electric pulse, researchers have immunized experimental animals against various strains of the virus. This approach could allow for the build up of vaccine reserves that could be easily and effectively dispensed in case of an epidemic. This study was published last week in PLoS ONE.

"This is the first study to show that a single DNA vaccine can induce protection against strains of pandemic flu in many animal models, including primates," says David B. Weiner, Ph.D., Professor of Pathology and Laboratory Medicine. "With this type of vaccine, we can generate a single construct of a pandemic flu vaccine that will give much broader protection."

Traditional vaccines expose a formulation of a specific strain of flu to the body so it can create immune responses against that specific strain. Conversely, a DNA vaccine becomes part of the cell, giving it the blueprint it needs to build antigens that can induce responses that target diverse strains of pandemic flu.

Avian flu is tricky. Not only is it deadly, but it mutates quickly, generating different strains that escape an immune response targeted against one single strain. Preparing effective vaccines for pandemic flu in advance with either live or killed viruses, which protect against only one or few cross-strains, is therefore very difficult. How to predict which strain of avian flu may appear at any time is difficult. "We are always behind in creating a vaccine that can effectively protect against that specific strain," notes Weiner.

Instead of injecting a live or killed virus, Penn researchers injected three different species of animal models with synthetic DNA vaccines that are not taken from the flu microbe, but trick the immune sy
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Newly approved ocular safety methods reduce animal testing
2. Data Published in Plastic and Reconstructive Surgery Show Cohera Medicals Surgical Adhesive, TissuGlu(R), Prevents Seroma Formation in Animal Abdominoplasty Model
3. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow in Indianapolis is Participating
4. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow in Cincinnati is Participating
5. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in Texas Participating
6. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in New Jersey Participating
7. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in Minnesota Participating
8. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in Michigan Participating
9. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in Colorado Participating
10. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas; Camp Bow Wow Locations in California Participating
11. Camp Bow Wow(R) Launches Fundraising Effort to Help Cure Cancer in Dogs, via Morris Animal Foundations Canine Cancer Campaign - Dogs Get Bandanas
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... York, New York (PRWEB) August 23, 2014 ... http://www.consumerinjurylawyers.com/wright-conserve-hip-replacement.html ) filed on behalf of individuals ... the Conserve hip replacement line continue to move ... of Georgia, Bernstein Liebhard LLP reports. According to ... established a bellwether trial program that would allow ...
(Date:8/23/2014)... (PRWEB) August 23, 2014 GBI Research, ... research: “Critical Care Therapeutics in Major Developed Markets to ... Products to Drive Market”, which provides in-depth analysis of ... Germany, Italy, Spain, Japan and Canada. The report provides ... market forecasts to 2020. It covers critical care indications ...
(Date:8/23/2014)... 23, 2014 Pixel Film Studios, a leader ... the release of ProIntro Vol.3, a customizable title tool ... professional tile just by dragging ProIntro Vol.3 in their timeline" ... is a definite time saver and i think our users ... 30 beautifully designed titles made with Final Cut Pro X ...
(Date:8/23/2014)... Youth substance abuse is a serious problem across ... TX. Substance abuse can happen to people of all ... dependency in higher numbers than ever before. Many ... don’t know where to find professional youth rehab. ... because most treatment options are designed for adults. The ...
(Date:8/23/2014)... 23, 2014 Summer vacation is almost over ... back in session. While shopping for school supplies and a ... Batzner encourages parents and students to also spend some time ... are excellent hitchhikers and thrive in heavily populated places,” said ... classrooms and dorms the perfect settings for bed bugs to ...
Breaking Medicine News(10 mins):Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 2Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 3Health News:Wright Conserve Hip Lawsuits Move Forward, as Federal Court Issues Order Pertaining to Bellwether Trials, Bernstein Liebhard LLP Reports 4Health News:Critical Care Therapeutics in Major Developed Markets to 2020 | Researchmoz 2Health News:Critical Care Therapeutics in Major Developed Markets to 2020 | Researchmoz 3Health News:A new plugin was announced today, ProIntro Vol.3 from Pixel Film Studios for Final Cut Pro X 2Health News:New Houston Hotline Assisting Juveniles in Locating Dependable Rehabilitation Help 2Health News:Expert Advice for a Bed Bug-Free School Year 2
... Wound ... ... Medical Technologies , Inc. today announced that its new HemCon Nasal Plugs and Seal-On devices ... The nasal care products will be available from HemCon directly to consumers under ...
... to keep beach underfoot than to dig in it, survey ... the dangers that lurk in sand castles, researchers warn. , ... of North Carolina at Chapel Hill have found that beachgoers ... at higher risk of developing diarrhea and gastrointestinal diseases than ...
... mathematics to take the guesswork out of efforts to ensure ... body parts will have enough blood and oxygen to survive ... model of tissue transfer, mathematicians have shown that they can ... transfer from one part of the body to another location ...
... MONTCLAIR, N.J., July 14 Parentgiving.com, the only comprehensive online resource ... aging parents, announces the launch of the first annual Parentgivers ... honor six selfless caregivers who care for an aging adult while ... July 13 via the Parentgiving website ( www.Parentgiving.com ) ...
... , TOLOCHENAZ, Switzerland, July 14 ... Approval for Medtronic,s Reclaim(R) DBS Therapy for Treatment,of Chronic, ... today announced that Reclaim(R) Deep Brain Stimulation (DBS),Therapy has ... chronic, severe treatment-resistant obsessive-compulsive,disorder (OCD).* This is the first ...
... Users, Guide, a comprehensive resource for endovascular and ... both book and CD formats. This unique reference ... Radiology, a national organization of physicians, scientists and ... through disease management and minimally invasive, image-guided therapeutic ...
Cached Medicine News:Health News:New HemCon/Seal-On Nasal Plugs Control Nosebleeds Quickly, Effectively and Comfortably 2Health News:New HemCon/Seal-On Nasal Plugs Control Nosebleeds Quickly, Effectively and Comfortably 3Health News:Germs Hold Court in Sand Castles 2Health News:Mathematics taking guesswork out of plastic surgery tissue transfer 2Health News:Mathematics taking guesswork out of plastic surgery tissue transfer 3Health News:Mathematics taking guesswork out of plastic surgery tissue transfer 4Health News:Nominate the Parentgivers of the Year 2Health News:World's First Deep Brain Stimulation Device Approved for Treatment of Psychiatric Condition in Europe 2Health News:World's First Deep Brain Stimulation Device Approved for Treatment of Psychiatric Condition in Europe 3Health News:World's First Deep Brain Stimulation Device Approved for Treatment of Psychiatric Condition in Europe 4Health News:New: Interventional radiology coding users' guide 2
(Date:8/22/2014)... On Aug. 20, at its annual meeting in ... voted on and approved a delegate resolution opposing the ... Cannabis Corp., a leading Canadian licensed producer of medicinal ... The CMA is quite right to point out that ... material, including medicinal cannabis. While some patients, particularly those ...
(Date:8/22/2014)... Equity Research highlights Epizyme (Nasdaq: EPZM - Free Report ... PNRA - Free Report ) as the Bear of the Day. ... FOLD - Free Report ), Sanofi (NYSE: SNY - ... ). Here is a synopsis of all five stocks: ... The biotech bull market is far from over due to ...
(Date:8/22/2014)... , Aug. 22, 2014  Cannabis Science, Inc. ... formulation-based drug development and related consulting, is pleased ... international medical cannabis conference taking place at the ... , on October 22, 2014.  The multilingual ... such as researchers, health professionals, and patients, to ...
Breaking Medicine Technology:Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 3Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 4Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 5Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 6Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 2Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 3
... ARBOR, Mich., Nov. 9 Thomson Reuters ... a leading clinical surveillance solution that enables hospitals to ... improve clinical quality and reduce total cost of treatment. ... at no additional cost. , CareFocus 2.0 ...
... Nov. 9 Arcadia Resources, Inc. (NYSE Amex: ... care services under the Arcadia HealthCare(SM) brand, has appointed ... will replace Tres Lund who announced his resignation from ... http://www.newscom.com/cgi-bin/prnh/20091109/DE07521 ) , Goldsmith is the Daniel ...
Cached Medicine Technology:Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs 2Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs 3Arcadia Resources Names Stephen Goldsmith to Board of Directors 2Arcadia Resources Names Stephen Goldsmith to Board of Directors 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: