Navigation Links
Penn State professor investigates estrogen, heart disease connection in women
Date:5/4/2009

A new study on old rats by a Penn State researcher will shed light on the connection between estrogen deficiency, heart disease and aging in women.

Heart disease is the leading cause of death in women over the age of 75. After menopause, women lose their ability to produce the hormone estrogen and researchers believe that low estrogen levels somehow make women more vulnerable to heart disease and heart attack.

Donna Korzick, associate professor of physiology and kinesiology in Penn State's College of Health and Human Development, has a $1.8 million, five-year project funded by the National Heart, Lung and Blood Institute of the National Institutes of Health to figure out why estrogen deficiency puts women in danger for heart disease.

Korzick will identify proteins in heart cells that might be affected by both aging and low estrogen levels. She will work with Bruce Stanley, director of scientific programs, Penn State Milton S. Hershey Medical Center, to identify these proteins.

"Proteins are the work horses of the cells," said Korzick. "When they become activated, they can trigger different functions within the cell. Some are even responsible for cell death as we age."

Proteins can become 'activated' in a variety of ways, including by low estrogen levels.

Korzick will analyze the proteins within one segment of heart cells, the mitochondria. These are the "gate keepers of cell survival," says Korzick. The mitochondria play a significant role in whether or not a cell lives or dies as we age, especially while experiencing a heart attack.

"Cell death is a natural process," explained Korzick "But when heart cells die, it means that the remaining cells have to do more work. In this way, cell death is directly linked to how well the heart can withstand a stress like a heart attack."

After identifying the heart cell's proteins, Korzick will determine which proteins respond to low-estrogen environments. She will then use protein-targeting drugs that can activate or inhibit specific proteins in the heart cells to change what is happening inside the cells. Korzick hopes that these experimental results will provide the missing piece to the estrogen deficiency -- heart disease puzzle.

Because of their short life span -- only two years, Korzick will look primarily at rats. According to Korzick, this short life span allows for a "true model of aging." Additionally, other researchers have already completed a large body of work involving aged rats so she will have a comprehensive knowledge base with which to work.

"At the very least, we'll be learning about heart disease in older females," says Korzick. "Right now, most of the estrogen-specific research is based on males, or young rats. Our research focuses on females, both young and old."

With the assistance of Tim Lancaster, who received his master's degree in kinesiology in 2008, Korzick has already identified nearly 600 proteins within the mitochondria of a rat heart cell.


'/>"/>

Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Related medicine news :

1. MyMedicalRecords, Inc. Stand-Alone Audited Financial Statements for the Period Ending December 31, 2008 to be Filed with the SEC Today, Monday, May 4, 2009
2. Vitamin E, Selenium and Soy Wont Prevent Prostate Cancer
3. Swine Flu Infections Now at 141 in 19 U.S. States
4. Althea Technologies Completes New State-of-the-Art, Commercial-Scale, Biologics and Injectables Manufacturing Facility
5. K-State professor awarded $1.48 million to study LASIK complictions
6. Oxygen Biotherapeutics, Inc. Files Cosmetic Product Ingredient Statement for new Oxycyte-based Cosmetic Gel
7. Texas Cancer Organizations Urge State Legislature to Fully Fund the Cancer Prevention and Research Institute of Texas
8. Official Statement From the Belize Tourism Board Regarding Swine Flu Pandemic
9. K-State Researcher Finds That the 1918 Spanish Flu Virus Can Infect Swine and Resulted in Current Lineage of H1N1 Swine Influenza Viruses
10. Penn State plays integral role in $35 million stress project
11. Wayne State University and Childrens Hospital of Michigan Research Team Discover Chemical That Plays a Major Role in Pediatric Obsessive-Compulsive Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... Sam & Associates Insurance ... planning, and related services to residents of the region, is embarking on a ... species and wild lands. , Endangered Species International is committed to ending the ...
(Date:3/22/2017)... ... March 22, 2017 , ... Donor Network West, the federally-designated ... Inc., announced the future opening of a CLIA certified dedicated laboratory in northern ... to determine the suitability of potential organ and tissue donors. This partnership ...
(Date:3/22/2017)... ... March 22, 2017 , ... An intensive search of the medical ... reports Leslie Norins, MD, PhD. He says investigating this possibility, is important ... virus and in new infections with HIV. , His findings appear on ...
(Date:3/22/2017)... ... March 22, 2017 , ... Intrinsic Imaging, LLC, an ... and operational excellence in oncology clinical trials, proudly announces today that it has ... non-small cell lung cancer and small cell lung cancer. , Throughout this trial, ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Jim Shortridge ... families and business owners, is joining the Teen Recovery Solutions organization in a ... , A growing number of Oklahoma teens and adolescents face problems from drugs, ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)...  Applied BioMath ( www.appliedbiomath.com ), the industry-leader ... development, today announced the latest line-up of speakers ... a day full of presentations, posters, and networking ... The focus is to learn about how mechanistic ... research and development. The event will ...
(Date:3/22/2017)... ROCHESTER, N.Y. , March 22, 2017 /PRNewswire/ ... Steriliz R-D™ Rapid Disinfector™ is the proven ultraviolet-C ... that cause healthcare-associated infections (HAIs). ... American Journal of Infection Control , the peer-reviewed ... testing and experiences of Vancouver General Hospital and ...
(Date:3/22/2017)... FinancialBuzz.com News Commentary  ... According to a report by the New Frontier Data, ... 2016, and is projected to grow at a compound annual growth ... 2025. The medical cannabis market is projected to grow at 12% ... an estimated $13.3 billion in 2025. These projections do not include ...
Breaking Medicine Technology: