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Penn Medicine study: Proton therapy cuts side effects for pediatric head and neck cancer patients
Date:9/24/2013

ATLANTA -- The precise targeting and limited dosing of radiation via proton therapy is proving to be an advantage in ongoing efforts to reduce treatment side effects among head and neck cancer patients, according to a new study of pediatric patients from researchers at the Perelman School of Medicine at the University of Pennsylvania. The results were presented Monday at the 55th annual meeting of the American Society for Radiation Oncology (ASTRO) conference.

"Children are especially susceptible to the side effects of radiation therapy, and treating them for head and neck cancers poses an additional challenge due to the risk of radiation to developing tissues," said the study's lead author, Christine Hill-Kayser, MD, an assistant professor of Radiation Oncology in Penn's Abramson Cancer Center. "Our findings using proton therapy for these patients, however, show that side effects are milder than those which are typically seen among children undergoing conventional radiation. We hope that this will translate to mean fewer late effects as they survive their cancer."

Although physicians have hypothesized about reduced toxicity and side effects with proton therapy because the modality spares most normal tissue from damage, clinical data on the new approach have not yet matured, particularly among pediatric cancer patients. The present study sought to shed more light on the issue by following a group of 25 patients, ranging in age from 1 to 21 years, all of whom received proton therapy at Penn Medicine's Roberts Proton Therapy as part of their treatment for various head and neck cancers, including rhabdomyosarcoma, Ewing's sarcoma, and salivary gland tumors, among others. Treatment toxicity was evaluated every week during proton treatment and every one to three months thereafter.

After a median of 13 months after treatment, 19 patients (76 percent) have no evidence of disease, 3 patients (12 percent) had developed local recurrence, and 5
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Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-200-2313
University of Pennsylvania School of Medicine
Source:Eurekalert

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