Navigation Links
Penn Medicine researcher unveils findings on 2 new weapons against thyroid cancer
Date:9/27/2013

AMSTERDAM -- For many years, patients with advanced thyroid cancer faced bleak prospects and no viable treatment options. But now, building on recent discoveries about the genetics and cell signaling pathways of thyroid tumors, researchers are developing exciting new weapons against the disease, using kinase inhibitors that target tumor cell division and blood vessels. Two recent clinical trials led by a researcher from the Perelman School of Medicine at the University of Pennsylvania showcase the great promise of these new approaches. The work will be presented at the European Cancer Congress (ECCO 17 - ESMO 38 - ESTRO 32) in Amsterdam today.

The first study provides additional data from the phase III DECISION trial of the drug sorafenib, a kinase inhibitor already approved for treatment of kidney and liver cancer, which was presented as a plenary during the 2013 annual American Society of Clinical Oncology meeting. In the newly released findings, lead author Marcia Brose, MD, PhD, an assistant professor in the department of Otorhinolarlyngology: Head and Neck Surgery and the division of Hematology/Oncology in the Abramson Cancer Center, and her colleagues examined the effectiveness of sorafenib on thyroid cancers that harbor BRAF and RAS mutations. They previously reported that for patients who received sorafenib, progression free survival was 10.8 months vs. 5.8 months in the placebo arm. Of the 417 patients enrolled in the trial, 256 had tumors collected for genetic analysis. As they expected, the most common mutations were found in the BRAF and RAS genes. However, the analyses show that all groups, regardless of the presence of a BRAF and RAS mutation benefited from treatment with sorafenib.

"Our results are important because they show that regardless of the presence of these two common genetic changes, the group that was treated with sorafenib did better than the placebo," Brose says. "There was no subgroup that didn't appear to benefit from
'/>"/>

Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-200-2313
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Institute for regenerative medicine to lead national effort to aid wounded warriors
2. Combining Chinese and Western medicine could lead to new cancer treatments
3. Emperor’s College of Traditional Oriental Medicine Celebrates 30th Anniversary
4. Three Physicians Join Texas Children’s Urology Division and Bring Robotics, Gender Medicine and Research Expertise
5. U.S. Preventive Medicine Awarded Exclusive, Workplace Health Program for Innovative Self-Funded Health Benefits Plan, Health Options Plus™
6. Metro-Detroit Prescription Medicine Dose Packs Available from MedExPack.com
7. SecondOpinions.com State-of-the-Art Teleradiology and Telemedicine Consumer Platform Introduces Employer Memberships With Most Competitive Rates in the Industry
8. South Jersey Family Medicine Switches to e-MDs for EHR, Practice Management and Patient Portal Solutions
9. Penn Medicine study: Proton therapy cuts side effects for pediatric head and neck cancer patients
10. Penn Medicine researchers harness the immune system to fight pancreatic cancer
11. The Australasian Academy of Dental Sleep Medicine (AustADSM) Provides Mini-Residency Programs for Post Graduates in the Dental Treatment of Snoring and Sleep Apnea
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... Avid collector Andrew Hawley, from Vintage Rock Posters, ... Seattle concert posters. The Doors were a smash hit after ... The Seattle Eagles Auditorium concert was held on July 23. ... Eagles Auditorium in November the same year. The artist that ... in three colors. The poster is a split fountain silkscreen ...
(Date:9/23/2014)... What information do patients need to ... (NQF) released a report ( http://bit.ly/1DwekE9 ), consumer ... ( http://bit.ly/1tX3lzA ) resulting from an in-depth look ... define affordability, and what information and changes are ... healthcare at the lowest possible cost. ...
(Date:9/23/2014)... Grinnell Mutual seeks submissions from the ... Midwest. Working Together Making It Better will provide ... projects positively impacting their communities. , “So many ... communities a better places,” said Grinnell Mutual ... Baker. “Their leadership—as coaches, as volunteers, as mentors—help ...
(Date:9/23/2014)... 2014 What: Rutgers Presbyterian Church, ... Side that embodies the inclusion and diversity of ... and the Ecological Crisis, a public lecture led ... Emerita of Old Testament at Louisville Presbyterian Seminary. ... that lends insight into current ecological problems, including ...
(Date:9/23/2014)... 23, 2014 (HealthDay News) -- Few children ... undergo behavioral therapy, and the rates vary six-fold ... study finds. Medication alone can manage symptoms ... better if they also receive behavioral therapy (psychotherapy), ... analyzed data in more than 1,500 counties across ...
Breaking Medicine News(10 mins):Health News:Finding Affordable Care: Asking the Right Question is Key 2Health News:Grinnell Mutual Invites Submissions for Innovative, Collaborative Local Projects in Its Second Annual Working Together Making It Better Promotion 2Health News:Inhabiting Eden: Christians, Scripture, and the Ecological Crisis – Public Lecture to Discuss Faith-Based Environmentalism 2Health News:Kids Taking ADHD Drugs Get Little Psychotherapy: Study 2
... sufficiency, new, antimicrobial-susceptibility system/panels for MRSA and other pathogens, ... and enhanced automated laboratory systems, ... will also be on view, WASHINGTON, July 29 ... will see Magellan Biosciences, continued,emergence as a new leader in ...
... people with disabilities when facing increasing healthcare costs, including added ... ... Belleville, IL (PRWEB) July 29, 2008 –- Rising ... a financial overload for families, according to http://allsup.com/Home.aspx ...
... Healthcare of Atlanta Signs Multi-Year Agreement with PureWellness to Provide ... ... Burlington, VT (PRWEB) July 29, 2008 -- PureWellness, ... solutions], announced it has signed an agreement with Children,s Healthcare ...
... a breakthrough test on its mesothelioma blog, which will allow early detection ... cancer kills a patient so quickly is due to the fact that ... ... -- LegalView, the most comprehensive legal resource available on the web, informed ...
... Database Now Offers Early Access to Research From ... and citation database of,peer-reviewed literature, today announced that ... papers published,prior to being printed, from journals produced ... Group (NPG). In the fall, AiPs,from BioMed Central ...
... age of your neighborhood may influence your risk of obesity, according ... The study, to be ... Preventive Medicine , linked the body mass index (BMI) of nearly ... The study found that residents were at less risk of being ...
Cached Medicine News:Health News:Magellan Biosciences Companies to Feature Diagnostic Products Designed to Improve Health Outcomes at the Clinical Lab Expo 2Health News:Magellan Biosciences Companies to Feature Diagnostic Products Designed to Improve Health Outcomes at the Clinical Lab Expo 3Health News:Magellan Biosciences Companies to Feature Diagnostic Products Designed to Improve Health Outcomes at the Clinical Lab Expo 4Health News:Magellan Biosciences Companies to Feature Diagnostic Products Designed to Improve Health Outcomes at the Clinical Lab Expo 5Health News:People with Disabilities Seek Ways to Manage Higher Healthcare Costs 2Health News:People with Disabilities Seek Ways to Manage Higher Healthcare Costs 3Health News:People with Disabilities Seek Ways to Manage Higher Healthcare Costs 4Health News:People with Disabilities Seek Ways to Manage Higher Healthcare Costs 5Health News:Nationally Recognized Pediatric Healthcare System Chooses PureWellness for Employee Wellness Program 2Health News:Nationally Recognized Pediatric Healthcare System Chooses PureWellness for Employee Wellness Program 3Health News:LegalView Unveils Details of a Breakthrough Mesothelioma Cancer Early Detection Test for Mesothelioma Patients 2Health News:LegalView Unveils Details of a Breakthrough Mesothelioma Cancer Early Detection Test for Mesothelioma Patients 3Health News:LegalView Unveils Details of a Breakthrough Mesothelioma Cancer Early Detection Test for Mesothelioma Patients 4Health News:Scopus Adds Pre-Print Research Abstracts From Four Prestigious Publishers 2Health News:Scopus Adds Pre-Print Research Abstracts From Four Prestigious Publishers 3Health News:This old healthy house 2
(Date:9/23/2014)... MINNETONKA, Minn. , Sept. 23, 2014   MedNet ... clinical study management systems, is pleased to announce that it ... for Clinical Data Management (SCDM) Annual Conference, to be held ... Las Vegas , Nevada. MedNet team members, in conjunction ... Partner Organizations who will also be in attendance, will ...
(Date:9/23/2014)... , September 23, 2014 ... que l,automobile, la santé, le ferroviaire ou ... plus connectées, donneront progressivement accès à leurs ... des nombreux capteurs installés au cœur des ... à plusieurs dizaines de milliards le nombre ...
(Date:9/23/2014)... 23, 2014 In industries such ... sectors, the machines are more and more connected and ... amounts of data are being harvested by numerous sensors ... number of connected machines is estimated at several dozen ... raises the fundamental question as to how big data ...
Breaking Medicine Technology:MedNet Solutions - Proud To Sponsor The SCDM 2014 Annual Conference 2Altran transforme le big data du monde industriel en nouveau business 2
... MORRISTOWN, N.J., March 25, 2011 Watson Pharmaceuticals, Inc. ... pharmaceutical company, today confirmed that it has received a ... the Federal Circuit related to its ongoing patent challenge ... seeking FDA approval to market a generic version of ...
... Asymchem Life Science (Tianjin) Co. Ltd, a leading research-based ... industry, with sites in the U.S. and China, is pleased ... Vice President of Quality Assurance as of March 1, 2011. ... 18 years, experience in the pharmaceutical industry (early and late ...
Cached Medicine Technology:Watson Confirms Favorable Appeals Court Ruling on Generic SEASONIQUE® Patent Challenge 2Mr. Robert Andrews Joins Asymchem Life Science (Tianjin) Co. Ltd. as Vice President of Quality Assurance 2
... 4, 8, or 12 channel pipettors. Angled ... nearly all of the solution. Corners have ... Made of natural virgin polystyrene containing no ... 152 mm L x 35 mm H ...
Volume: 5 ml; Volume Graduation: 1/10 ml...
... for use with measuring pipettes, enables you to ... works with all types of glass or plastic ... to 100 mL.Gilsons Pipette Aid is equipped with ... protect the mechanism of the device from contamination ...
Application: Safe and convenient filling and dispensing of glass and plastic pipets....
Medicine Products: