Navigation Links
Penicillin Prevents Return of Leg Infection Called Cellulitis: Study
Date:5/1/2013

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, May 1 (HealthDay News) -- For people who have suffered from cellulitis of the leg, a long course of low-dose penicillin prevents the painful infection from returning, British researchers report.

Once the penicillin is stopped, however, its protective effect diminishes and the condition can flare up again, the researchers noted.

"Low-dose penicillin substantially reduces the risk of further episodes of leg cellulitis in those who have had two or more previous episodes," said lead researcher Hywel Williams, a professor of dermato-epidemiology at the University of Nottingham.

"The penicillin reduced recurrences from 37 percent in the group taking placebo to 22 percent in those taking penicillin," Williams said. "But this effect only occurred in the period that folks took the penicillin. When they stopped the 12 months of penicillin, the protective effect wore off."

Cellulitis is a common infection of the skin and deep underlying tissues. The two most common causes are Staphylococcus (staph) bacteria and group A strep. The bacteria enter the body through an injury such as a bruise, burn, surgical cut or wound, as well as through athlete's foot.

Symptoms can include fever and chills, swollen glands or lymph nodes, and a rash with painful, red, tender skin. In addition, the skin may blister and scab over.

The usual treatment is antibiotics, but the condition commonly returns when treatment is stopped.

Doctors and their patients now have reliable information on a possible way of reducing recurrences of this disabling and painful recurrent disease, Williams said.

"We now know for the first time that low-dose penicillin works, but we don't know how long it should be taken for and whether giving long-term antibiotics may cause resistance problems in the community in the long term, or whether it should be given for people with a first episode of cellulitis or just those with two or more previous episodes," he said.

The report was published in the May 2 issue of the New England Journal of Medicine.

One expert doesn't think this treatment is anything new.

"I know keeping you on antibiotics will prevent cellulitis from recurring," said Dr. Michele Green, a dermatologist at Lenox Hill Hospital, in New York City. "The problem is that the protective effect diminishes once drug therapy is stopped.

"This is what I do with older people. I keep them on antibiotics for a longer period of time so that they don't have a problem, but once you take them off they're just as vulnerable as they were before," Green said. "That's just common sense."

In addition, Green worries that keeping people on antibiotics for extended periods helps build the bacteria's resistance to the drug.

For the new study, Williams' team randomly assigned 274 people who had suffered from cellulitis of the leg that had been treated to one year of treatment with low-dose penicillin or placebos.

Over three years of follow-up, people taking penicillin saw a recurrence of cellulitis 626 days after the drug was stopped, compared with 532 days for those in the placebo group, the researchers found.

While on penicillin, 30 people had a recurrence of cellulitis, compared with 51 patients taking the placebo, they found.

More information

To find out more about cellulitis, visit the U.S. National Library of Medicine.

SOURCES: Hywel Williams, Ph.D., professor, dermato-epidemiology, University of Nottingham, England; Michele Green, M.D., dermatologist, Lenox Hill Hospital, New York City; May 2, 2013, New England Journal of Medicine


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Economic analysis finds penicillin, not "the pill," may have launched the sexual revolution
2. New drug prevents spread of human prostate cancer cells
3. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
4. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
5. Intense light prevents, treats heart attacks
6. Biosynthetic grape-derived compound prevents progression of Alzheimers disease in mice
7. Fatty acid found in fish prevents age-related vision loss: U of A medical research
8. CNIO researchers discover a new therapy that prevents lung cancer growth in mice
9. Pitt: Targeted oxidation-blocker prevents secondary damage after traumatic brain injury
10. Treated Vaginal Ring Prevents HIV in Monkeys
11. A carefully scheduled high-fat diet resets metabolism and prevents obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penicillin Prevents Return of Leg Infection Called Cellulitis: Study
(Date:6/26/2017)... ... June 26, 2017 , ... Dr. Martin Bastuba, MD, FACS, ... with the Fertility Center of California, is pleased to announce the addition of ... and TESA (percutaneous testicular sperm extraction). These minimally invasive treatments are primarily used ...
(Date:6/26/2017)... ... 26, 2017 , ... If the devil is in the ... these days. According to recent estimates, 75 – 80% of the medical bills ... studies point to Electronic Health Records (EHR) with automated features designed to ease ...
(Date:6/25/2017)... ... June 25, 2017 , ... Republicans in the United States Senate on Thursday ... Better Care Reconciliation Act. It differs significantly from the American Health Care Act, which ... in committee, or the House will have to take up the Senate version as-is, ...
(Date:6/24/2017)... ... June 24, 2017 , ... Genes Advice, ... medications in select Florida and Texas doctors' offices and clinics. This breakthrough testing ... of genetic testing recognizes the role genes play in determining an individual's tolerance ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... announced the launch of Care Management Alerts and Dashboards, an innovative new service ... Rhode Island. , RIQI’s Care Management Alerts and Dashboards provide near real-time data ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)... ANGELES , June 8, 2017   Responding to ... drug oversight and the death of singer Chris Cornell ... on Human Rights International offers a free online ... better educate consumers and families about psychotropic drug risks. ... Ledger , who died from an accidental overdose, has called ...
(Date:6/7/2017)... Endo International plc (NASDAQ: ENDP ... Joseph R. Goodwin , U.S. District Court Judge ... , entered a case management order in MDL ... Liability Litigation (the "MDL") that includes a provision requiring ... disclosures on specific causation within one hundred twenty (120) ...
(Date:6/7/2017)...  Diplomat Specialty Infusion Group, a brand of Diplomat Pharmacy, Inc. ... Iowa location. The Iowa ... an ISO 7 cleanroom—the standard needed to compound intravenous (IV) nutrition ... of pollutants. "Our new cleanroom ... serve our Iowa patients," said Phil ...
Breaking Medicine Technology: