DALLAS Aug. 19, 2010 A pediatric urologist at UT Southwestern Medical Center has pioneered a successful surgical procedure for young girls who have absent or malformed vaginas, a condition that affects about one in 4,000 females.
Unknown causes and certain genetic disorders can cause girls to be born with these defects, along with other birth defects that can accompany the vaginal problems, including abnormal neck, absent or malformed uterus and fallopian tubes, absent kidneys or abnormal external genitals.
"It was initially challenging to construct a treatment for something so rare," said Dr. Linda Baker, professor of urology at UT Southwestern and a surgeon at Children's Medical Center Dallas. "My goal was to develop a treatment that would lead to a natural repair at the first operation, as well as a method to correct vaginal scarring in girls and women who'd had prior, unsuccessful vaginal surgeries."
Existing procedures for these conditions include using portions of a patient's skin or lower intestine to build the vaginal walls and an external vaginal opening. Dr. Baker began studying other areas of the body for potential healthy tissue to use and discovered that interior cheek tissue, or buccal mucosa, had several similar physiological qualities to vaginal tissue in its thickness, elasticity, strength and visual similarities.
"There were many surgical methods for reconstructing the vagina, but when I began seeing these patients, I thought the results were not natural-looking and inadequate in many cases," said Dr. Baker, director of the Sarah M. and Charles E. Seay Center for Pediatric Urology. "Too many suffered with complications from these types of vaginal reconstructions, often leading to painful intercourse in adulthood."
The surgery begins by removing a portion of the top layer of cheek tissue from inside a patient's mouth. That tissue is then stretched and made into a graft that is perforated, much like
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UT Southwestern Medical Center