Paul Marks prize recognizes 3 young cancer r...(ome Atlas (TCGA) project which was initi...),Health

Date:9/28/2009

ome Atlas (TCGA) project, which was initiated by the National Cancer Institute in 2006 to improve the understanding of the molecular basis of cancer. Last fall, he was one of two lead authors of TCGA's first major paper, a comprehensive characterization of the genes and pathways that are important in glioblastoma brain tumors. Finally, Dr. Meyerson's laboratory has developed a new approach to find cancer-causing microbes.

"With the ongoing revolution in genome technology, we need complete characterization of the cancer genome and all the genetic alterations that cause cancer," Dr. Meyerson said. "We're at a point where it's possible, and this goal is very much in sight."

"Matthew's findings have changed the treatment of adenocarcinomas of the lung," said James D. Griffin, Chairman of the Department of Medical Oncology at Dana-Farber, who nominated Dr. Meyerson for the prize. "This work and his ongoing work characterizing other genomic changes in lung cancers have placed him at the forefront of developing personalized therapy for patients with this deadly disease."

Dr. Meyerson received his MD degree from Harvard Medical School and his PhD degree from Harvard University.

David Sabatini

Dr. Sabatini is an associate professor of biology at the Massachusetts Institute of Technology and a member of the Whitehead Institute for Biomedical Research. He is also an HHMI investigator. While he was still in graduate school, Dr. Sabatini identified the mTOR protein kinase, a key protein in regulating cell growth, proliferation, and survival. He has continued to study the protein and its signaling pathway for much of his career, characterizing other related proteins and helping to determine how the mTOR pathway relates to cancer.

"All cells, including cancer cells, need to generate mass and ramp up production of all of their components in order to grow and divide," Dr. Sabatini explained. "We now know that mTOR is the maste
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Contact: Kathleen Gibson gibsonk@mskcc.org 212-639-3573 Memorial Sloan-Kettering Cancer Center Source:Eurekalert

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