Paul Marks prize recognizes 3 young cancer r...(ostic and therapeutic approaches said D...),Health

Date:9/28/2009

ostic and therapeutic approaches," said David Ginsburg, a professor at the University of Michigan Medical School and an HHMI investigator, who nominated Dr. Chinnaiyan for the award. "There are no more than a handful of physician-scientist cancer researchers at this phase of their careers who could even be compared to his level of research accomplishment and promise for the future."

Dr. Chinnaiyan received his MD degree and a PhD degree in pathology from the University of Michigan Medical Center.

Matthew Meyerson

Dr. Meyerson is Director of the Center for Cancer Genome Discovery at Dana-Farber Cancer Institute, a professor of pathology at Harvard Medical School, and a senior associate member of the Broad Institute of MIT and Harvard. He is a leader in the field of cancer genomics, especially in the area of lung cancer. A major focus for his work has been determining the role that mutations in the epidermal growth factor receptor (EGFR) gene play in lung cancer, especially its response to the targeted therapies erlotinib (Tarceva) and gefitinib (Iressa).

In 2004, Dr. Meyerson's team was one of three groups to report that EGFR mutations in tumor cells were linked to patients' responses to gefitinib. His group also found that these mutations were more common in the lung tumors of nonsmoking women and people of East Asian descent. Molecular testing for EGFR mutations is now a standard part of lung cancer diagnosis at most hospitals, and the test's results determine which therapies individual patients will receive.

Dr. Meyerson has been active in the study of other cancer-related genes, including JAK2, which is a factor in some types of leukemia; ALK, which is activated in lung cancer and neuroblastoma; and FGFR2, which is activated in endometrial cancer. His laboratory has made other discoveries regarding the lung adenocarcinoma genome, including activation of the NKX2-1 and TERT genes. He is also a leader in the Cancer Gen
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Contact: Kathleen Gibson gibsonk@mskcc.org 212-639-3573 Memorial Sloan-Kettering Cancer Center Source:Eurekalert

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