Navigation Links
Paul Marks prize recognizes 3 young cancer researchers
Date:9/28/2009

Professor of Pathology and a professor in the Department of Pathology and Urology at the University of Michigan Medical Center. He is also a Howard Hughes Medical Institute (HHMI) investigator and an American Cancer Society Research Professor. His most important discovery to date is the finding that more than half of all prostate cancers are the result of a gene fusion known as TMPRSS2-ETS. Oncogenic gene fusions result when pieces of chromosomes break apart and reconnect in such a way that they encode for a cancer-causing protein.

Dr. Chinnaiyan made the discovery while studying the genetic changes in a large collection of prostate tumor samples from patients. "At the time, gene fusions were thought to occur only in blood cancers such as leukemias and lymphomas, but not in solid tumors," Dr. Chinnaiyan explained. (The best-known oncogenic fusion gene was BCR-ABL, the cause of chronic myeloid leukemia, which is the target of the drug imatinib [Gleevec].) "We were not looking for these types of genes, so the finding was serendipitous."

Today researchers believe that the TMPRSS2-ETS fusion drives the formation of many prostate cancers, but so far they have been unable to target it and block its activity. Finding small-molecule drugs to inhibit cancer growth is now an important focus of Dr. Chinnaiyan's work. He is also initiating new research projects to look for cancer-causing gene fusions in other solid tumors, including breast cancer. Dr. Chinnaiyan has been active in the wider research community as well, as co-creator of the Oncomine Research Platform, an online database containing cancer gene expression analysis information for academic researchers. He is also a board-certified pathologist and spends part of his time developing and implementing new molecular tests for the diagnosis and prognosis of cancer.

"Arul's discovery of this unique fusion in prostate cancer has opened up numerous opportunities for the development of novel diagn
'/>"/>

Contact: Kathleen Gibson
gibsonk@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Pelosi Remarks at the Congressional Black Caucus Foundations Annual Legislative Conference
2. Regence BlueShield Receives Top Marks in Insurance Survey
3. Pelosi Remarks at Democratic Steering and Policy Committee Forum on Health Insurance Reform
4. Hard Rock International Marks 10 Years Of Support For Breast Cancer Awareness And Research With 2009 PINKTOBER(TM) Campaign Featuring Melissa Etheridge, The Bangles, Melanie C, Joss Stone And More
5. Pennsylvanias Clean Indoor Air Act Marks One Year Anniversary
6. Pelosi, Reid Remarks at Press Availability Following Meeting With President Obama
7. Quest Diagnostics Marks Sixth Year on Dow Jones Sustainability Index
8. Minneapolis-based CornerHouse Marks 20th Anniversary of Helping Sexually Abused Children Around the World
9. Pennsylvania Patient Safety Authority Marks Milestone With One Million Reports
10. Pelosi, Democratic Leaders Remarks Today at News Conference on Legislative Accomplishments
11. Western Wayne Family Health Center -- Taylor Dedication Ceremony Marks Important Step in Providing Healthcare to Underinsured and Uninsured
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... September 03, 2015 , ... “We wish to ... impact the delicate life balance between work and leisure to the benefit of ... Leaptrott, CEO , A LifeMinder Plus® Emergency Care Document Set duly executed set ...
(Date:9/3/2015)... ... September 03, 2015 , ... ... will be participating at the highly anticipated Mississippi Gulf Babypalooza on September 19, ... from all over, from Gulfport, Biloxi, and beyond. We will be discussing setting ...
(Date:9/3/2015)... ... ... Local filmmakers and now co-hosts of the up and coming podcast Path11 Podcast ... great success in launching their Path11 Podcast with 23 episodes released since April 2015. ... the well known Spiritual Catalyst and Linda Howe, leader in the field of Akashic ...
(Date:9/3/2015)... ... 03, 2015 , ... Fashion designer Kim (29 years old, Honolulu, HI) designed ... of the hit ABC series “Extreme Weight Loss” Season 5 . Standing just ... provided herself with the motivation to transform when she designed a drop-dead-gorgeous dress and ...
(Date:9/2/2015)... DC (PRWEB) , ... September 03, 2015 , ... ... of nominations to determine who among America’s policymakers, public servants, activists, corporate executives, ... the nation’s health care. This year, that process led the magazine to tap ...
Breaking Medicine News(10 mins):Health News:LifeMinder Plus® Announces Emergency Care Document Set Giveaway for America 2Health News:LifeMinder Plus® Announces Emergency Care Document Set Giveaway for America 3Health News:State Farm Agent EJ Roberts to Help Expecting Mothers at the Mississippi Gulf Babypalooza 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 2Health News:Path 11 Podcast Now Features over 20 Metaphysical Discussions on iTunes and Growing 3Health News:New “Extreme Weight Loss” Video Blog from the CU Anschutz Health and Wellness Center: Kim Begins with the End in Mind and Designs a Fashionable Future 2Health News:New “Extreme Weight Loss” Video Blog from the CU Anschutz Health and Wellness Center: Kim Begins with the End in Mind and Designs a Fashionable Future 3Health News:NLN CEO Dr. Beverly Malone Named One of 100 Most Influential in Health Care 2Health News:NLN CEO Dr. Beverly Malone Named One of 100 Most Influential in Health Care 3
... ... launched TCSterps On-Demand, a comprehensive Video Relay Interpreting (VRI) service providing Sign Language ... ... 2009 -- TCS Associates , ( http://www.TCSassociates.com ) a total solutions provider ...
... ... a new Web site: www.pharmacypainsummit.com , designed to encourage thought sharing and learning ... ... Southern Illinois University Edwardsville School of Pharmacy has launched a new Web ...
... Oct. 1 The Centers for Medicare & Medicaid ... a qualified survey vendor for the Home Health Care ... HH-CAHPS survey is a measure of patients, experiences with ... health agencies participating in the national HH-CAHPS implementation must ...
... led by Mayo Clinic researchers has found that ulcerative ... after a year when treated with infliximab, according to a ... . Ulcerative colitis, an inflammatory bowel disease (IBD) that ... pain and diarrhea. Like Crohn,s disease , another common ...
... When used "off-label," the antidepressant amitriptyline works ... gastrointestinal disorders in children, according to a new ... of the American Gastroenterological Association (AGA) Institute. To ... AGA,s YouTube Channel at www.youtube.com/AmerGastroAssn. "Many ...
... team, coordinating local efforts for concerned groups , -Samoan ... from Seattle , -Former NFL quarterback "Throwin, Samoan" Jack ... 30 Christian relief group World Vision is coordinating ... tsunami that struck the islands of Samoa and American ...
Cached Medicine News:Health News:TCS Associates: A Sign Language Interpreting Agency Launches New Video Remote Interpreting (VRI) Service called TCSterps On-Demand 2Health News:TCS Associates: A Sign Language Interpreting Agency Launches New Video Remote Interpreting (VRI) Service called TCSterps On-Demand 3Health News:SIUE School of Pharmacy Launches Collaborative Site for Pain, Palliative Care Pharmacy 2Health News:SIUE School of Pharmacy Launches Collaborative Site for Pain, Palliative Care Pharmacy 3Health News:CMS Approves Press Ganey as a Qualified Home Health Care CAHPS Survey Vendor 2Health News:CMS Approves Press Ganey as a Qualified Home Health Care CAHPS Survey Vendor 3Health News:Ulcerative colitis treatment reduces need for surgery by almost half 2Health News:Antidepressant and placebo are equally effective in child pain relief 2Health News:World Vision Responding to Tsunami in Samoan Islands 2
(Date:9/2/2015)... , Sept. 2, 2015 Research and Markets ... "Pharmaceutical Regulatory Affairs in China (Basel, Switzerland - November 26-27, ... seminar will provide a detailed overview of the key areas ... Hong Kong , Macau ... - All important aspects of gaining and ...
(Date:9/2/2015)... YORK , Sept. 2, 2015  Seeger Weiss ... implant bellwether trial will commence October 13, 2015. ... using the 510K fast-track approval program, Zimmer NexGen knee ... program only requires that companies provide evidence that the ... product in order to gain permissions. ...
(Date:9/2/2015)... , Sept. 2, 2015 Research and Markets ... "New EU Pharmacovigilance Legislation (London, UK - November ... The 15 new EU modules concerning Pharmacovigilance are ... is conducted in Europe . The ... modules and their requirements, examine how they overlap and ...
Breaking Medicine Technology:Pharmaceutical Regulatory Affairs in China Seminar: Basel, Switzerland - November 26-27, 2015 2Seeger Weiss LLP Reports That Zimmer NexGen Knee MDL Bellwether Trial Date Set For October 13, 2015 2
... Aug. 1, 2011 Reportlinker.com announces that ... in its catalogue: Insulin- ... This package contains 14 ... European countries: Austria, Belgium, Denmark, Finland, France, ...
... Aug. 1, 2011 Reportlinker.com announces that ... in its catalogue: Vaccines ... http://www.reportlinker.com/p0578257/Vaccines---Eastern-Europe.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_and_Medication This package contains ... Eastern European countries: Bulgaria, Czech Republic, Estonia, ...
Cached Medicine Technology:Insulin- Western Europe 2Vaccines - Eastern Europe 2
Ferris Smith Rongeurs, 12 overall length 300 mm....
It is designed for rigid skeletal fixation. These pins are constructed of stainless steel and can be removed for sterilization and reuse....
It is designed for rigid skeletal fixation. These pins are constructed of stainless steel and can be removed for sterilization and reuse....
... It is designed for rigid ... surgeon greater freedom in positioning ... rigid skeletal fixation is designed ... or sitting positions. Craniotomies can ...
Medicine Products: