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Patients with post-ACS depression benefitted from active treatment in clinical trial
Date:3/8/2013

antly more in the active treatment group than in the usual care group (differential change between groups, -3.51 BDI [Beck Depression Inventory] points. Mental health costs were higher for the active treatment group than for the usual care group (adjusted change, $687), while average hospital costs were lower in the intervention group (adjusted change, -$1010). As a result of the offset, overall health care estimated costs in the study intervention group were not statistically different than in the comparison group (adjusted change, -$325), according to the results.

"A large phase 3 trial would inform evidence-based depression treatment guidelines for patients with an ACS, and even has the tantalizing possibility of answering the important question of whether treating depression in patients with ACS lowers mortality and recurrence rates," the study concludes.

(JAMA Intern Med. Published online March 7, 2013. doi:10.1001/jamainternmed.2013.915. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: An author made a conflict of interest disclosure. The work was supported by grants from the National Institutes of Health (NIH), Bethesda, Md., and was supported in part by Columbia University's CTSA from the National Center for Advancing Translational Sciences/NIH. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Commentary: Benefits, Costs of Improving Depression Treatment for Patients With Heart Disease

In a related commentary, Gregory E. Simon, M.D., M.P.H., Group Health Cooperative, Seattle, writes: "In this issue of JAMA Internal Medicine, Davidson et al describe the benefits of an organized depression care program for outpatients experiencing significant symptoms of depression after acute coronary synd
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Contact: Elizabeth Streich
estreich@columbia.edu
212-305-3689
JAMA and Archives Journals
Source:Eurekalert

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