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Patients with lower urinary tract symptoms more likely to suffer from metabolic syndrome
Date:6/19/2009

five characteristics of 1) waist circumference greater than 102 cm; 2) systolic blood pressure 130 mm Hg or greater or diastolic blood pressure 85 mm Hg or greater, or antihypertensive medication use; 3) HDL cholesterol less than 40 mg/dl or lipid medication use; 4) self-reported type 2 diabetes or increased blood sugar or diabetes medication use; 5) triglycerides greater than 150 mg/dl.

An increased odds ratio of 1.68 for metabolic syndrome was observed in men with mild to severe LUTS symptoms compared to those with few or no symptoms. A statistically significant association was observed between the metabolic syndrome and a voiding symptom score of 5 or greater (odds ratio 1.73), but not for a storage symptom score of 4 or greater (odds ratio 0.94). Increased odds of the metabolic syndrome were observed even with mild symptoms, primarily for incomplete emptying, intermittency and nocturia. These associations were observed primarily in younger men (younger than 60 years) and were null in older men (60 years or older).

In an Editorial Comment accompanying the article Dr. Brett A. Laven, Clinic of Urology, Milwaukee, states that "The findings presented become increasingly significant as society weighs the costs of delivering health care to a population with an increased incidence of obesity/MetS. It has been estimated that more than 1 billion people are currently overweight and the prevalence in children has considerably increased. The possibility of pharmaceutically targeting the adipokine system, thus influencing a neuroendocrine pathway that might impact LUTS, is intriguing."


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Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences
Source:Eurekalert

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