Navigation Links
Patients with lower urinary tract symptoms more likely to suffer from metabolic syndrome
Date:6/19/2009

New York, NY, June 18, 2009 Researchers have determined that individuals with mild to severe symptoms of lower urinary tract symptoms (LUTS) are more likely to suffer from metabolic syndrome (MetS), a collection of cardiovascular risk factors thought to be linked by insulin resistance). LUTS encompass voiding (incomplete emptying, weak stream, intermittency, straining) and storage (frequency, urgency, nocturia) difficulties.

In a study published in the August 2009 issue of The Journal of Urology, researchers from the New England Research Institutes, Watertown, Massachusetts; the Department of Urology, Northwestern University, Chicago, Illinois; Cornell University, Weill Medical College; Pfizer Inc, New York, New York; and Pfizer Ltd, Sandwich, United Kingdom, explored the possible association of LUTS with MetS using data from the Boston Area Community Health Survey. 2,301 men 30 to 79 years old were interviewed and analyses were conducted on 1,899 men who provided blood samples. Body measurements and blood pressure readings were done, and self-reported medical histories were taken.

The authors state, "These findings have important diagnostic and management implications. Patients who present with components of metabolic dysfunction should be routinely queried with respect to urological function, particularly voiding symptoms such as intermittency, incomplete emptying and nocturia, as well as the degree of associated bother. Sexual dysfunction symptoms, particularly erectile dysfunction, are similarly reported by the majority of men with MetS and should be routinely evaluated."

LUTS were assessed using the American Urological Association symptom index (AUASI), a clinically validated measure of urological symptoms. The AUASI was categorized into two groups as none or mild symptoms (AUASI less than 8) versus moderate or severe symptoms (AUASI 8 or greater). In this analysis MetS was defined as the presence of three or more of the five characteristics of 1) waist circumference greater than 102 cm; 2) systolic blood pressure 130 mm Hg or greater or diastolic blood pressure 85 mm Hg or greater, or antihypertensive medication use; 3) HDL cholesterol less than 40 mg/dl or lipid medication use; 4) self-reported type 2 diabetes or increased blood sugar or diabetes medication use; 5) triglycerides greater than 150 mg/dl.

An increased odds ratio of 1.68 for metabolic syndrome was observed in men with mild to severe LUTS symptoms compared to those with few or no symptoms. A statistically significant association was observed between the metabolic syndrome and a voiding symptom score of 5 or greater (odds ratio 1.73), but not for a storage symptom score of 4 or greater (odds ratio 0.94). Increased odds of the metabolic syndrome were observed even with mild symptoms, primarily for incomplete emptying, intermittency and nocturia. These associations were observed primarily in younger men (younger than 60 years) and were null in older men (60 years or older).

In an Editorial Comment accompanying the article Dr. Brett A. Laven, Clinic of Urology, Milwaukee, states that "The findings presented become increasingly significant as society weighs the costs of delivering health care to a population with an increased incidence of obesity/MetS. It has been estimated that more than 1 billion people are currently overweight and the prevalence in children has considerably increased. The possibility of pharmaceutically targeting the adipokine system, thus influencing a neuroendocrine pathway that might impact LUTS, is intriguing."


'/>"/>

Contact: Linda Gruner
jumedia@elsevier.com
212-633-3923
Elsevier Health Sciences
Source:Eurekalert

Related medicine news :

1. VIDEO: Cancer Treatment Centers of America Selects Site in GA for Proposed Hospital Serving Patients in Southeast
2. Omega-3 Fatty Acids Might Curb Depression in Heart Patients
3. House Bill to Provide Cancer Patients With Solution for Quality Cancer Care Within an Equitable Medicare Model
4. Patient Advocacy Groups Urge Greater Focus on Patients Choice and Privacy Rights in Health-Reform Debate
5. New findings encourage more vigilant monitoring of seizure activity among intensive care patients
6. Squeamish Colorado Dental Patients Get Drilled By Self-Interested Regulators
7. AMA Supports Health System Reform Alternatives Consistent With Principles of Pluralism, Freedom of Choice, Freedom of Practice and Universal Access for Patients
8. Lifelike Robot Provides Innovative Rehabilitation Treatment for Patients
9. Calling All Heart Patients
10. Telemedicine expands reach of care for Parkinsons patients
11. New Study Finds 1 in 4 Multiple Sclerosis Patients With High Out-of-Pocket Costs Not Filling Prescriptions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... Carolina (PRWEB) , ... August 22, 2017 , ... ... advisor. Mr. Stewart is the Founder and Managing Member for t4 Leadership Development ... have become critical to his definition of “success”: physician leadership development, servant leadership, ...
(Date:8/22/2017)... ... August 22, 2017 , ... Although Labor Day is ... many communities have begun providing weekend displays, and numerous households celebrate the unofficial end ... can be downright terrifying for pets. , Kris Zambo, owner of Dynamite ...
(Date:8/21/2017)... ... August 22, 2017 , ... ... Stevens as a 2017-2018 inductee into its VIP Woman of the Year ... is the nation’s leading networking organization exclusively for professional women, boasting more than ...
(Date:8/21/2017)... ... August 21, 2017 , ... SportsEngine, Inc. , ... Official Technology Partner of North Country Region Volleyball and will power registration, scheduling, ... along with providing sport management software to their member clubs. , ...
(Date:8/21/2017)... ... August 21, 2017 , ... Duncan Insurance ... serving the people of Michigan. The new initiative fundraises for the Kalamazoo Humane ... very forefront of animal protection and welfare by addressing the root causes of ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)...  Diplomat Pharmacy, Inc. (NYSE: DPLO), the nation,s largest independent ... 30, 2017.  All comparisons, unless otherwise noted, are to the ... Second Quarter 2017 Highlights include: ... increase of 3.5% Total prescriptions dispensed of ... 7.5% versus 7.6% Gross profit per ...
(Date:8/3/2017)... DIEGO , Aug. 3, 2017  Opioid addiction ... diseases driving up healthcare costs and threatening outcomes, were ... lab supply and IVD industry that support them, met ... care market researcher said that drugs of abuse, procalcitonin ... and sessions at the organization,s 69th meeting in ...
(Date:8/2/2017)... , Aug. 2, 2017 CaryRx, a next-generation full-service ... delivery service for patients in the Washington D.C. ... retail pharmacy by providing delivery of medications through the convenience ... future delivery or delivered within one hour to any location ... excited to bring this invaluable service to Washington ...
Breaking Medicine Technology: