Navigation Links
Patients with PsA treated with ustekinumab are twice as likely to achieve acr20 vs. placebo
Date:6/8/2012

Berlin, Germany, June 8 2012: A new Phase III study presented today at EULAR 2012, the Annual Congress of the European League Against Rheumatism, shows that patients with active psoriatic arthritis (PsA) treated with Ustekinumab (UST) 90mg were more than twice as likely to achieve the study's primary endpoint, ACR20* at 24 weeks, than those treated with placebo (49.5% vs 22.8%). 42.4% of patients treated with UST 45mg were also more likely to achieve ACR20 at 24 weeks compared to placebo.

Significant improvements were also seen with UST 45mg and 90mg in ACR50* (24.9% and 27.9% respectively vs 8.7%), in ACR70* (12.2% and 14.2% respectively vs 2.4%) and in DAS28-CRP** responses at week 24 vs placebo (65.9% and 67.6% for UST 45mg and 90mg respectively vs 34.5%). Changes from baseline in HAQ-DI*** at week 24 were also significantly greater in patients treated with UST versus placebo and for a greater proportion of patients these changes were clinically meaningful (≥0.3).

In addition, patients in the UST groups who were affected with enthesitis (n=425) or dactylitis (n=286) at baseline, showed greater improvements at week 24 than those in the placebo groups.

"There are a number of patients with psoriatic arthritis who do not respond to currently available treatment options, including biologic medicines targeting TNF. As physicians, we struggle to manage such people as well as we would like," commented Professor Iain McInnes, lead study author from University of Glasgow, Scotland. "The development of this new medicine is a welcome step forward. These results highlight not only Ustekinumab's efficacy but also its promising safety profile. We look forward now to seeing how it compares in trials with standard treatments."

Safety profiles were similar between the two groups. The proportion of patients suffering from one or more adverse events was 41.8% in the UST group compared to 42% in the placebo group. Infections were the most common adverse event; serious adverse events (>1) were reported in 1.7% UST and 2% placebo of patients.

This double-bind placebo controlled trial followed 615 patients with active PsA (≥5 swollen joint counts and ≥5 tender joint counts; c-reactive protein ≥0.3mg/dL) despite treatment with disease modifying anti-rheumatic drugs (DMARDs) and/or non-steroidal anti inflammatory drugs (NSAIDs). Patients were randomised to UST 45mg, 90mg or placebo at weeks zero, four and 12 weeks thereafter. At week 16, patients with <5% improvement in tender joint counts and swollen joint counts entered blinded early escape (PBO to UST 45mg, UST 45mg to UST 90mg, UST 90mg to UST 90mg). Stable concomitant methotrexate (MTX) use was permitted but not mandated. Nearly half of the patients studied used concomitant MTX at baseline but this did not alter the likelihood of benefit of UST.


'/>"/>

Contact: Candice Debleu
eularpressoffice@cohnwolfe.com
44-789-438-6425
European League Against Rheumatism
Source:Eurekalert

Related medicine news :

1. Personalizing biologic treatment to individual patients with rheuatoid arthritis is cost-effective
2. Patients taking certolizumab pegol are twice as likely to achievE ACR20 compared to placebo
3. Control of disease activity and biologic treatment increase life expectency in RA patients
4. Haematopoietic stem cell transplantation increases survival in systemic sclerosis patients
5. Financial Worries Add to Cancer Patients Burden
6. Caring for patients with fecal incontinence costs more than $4,000 per person each year
7. Pre-op Treatments Boost Survival for Esophageal Cancer Patients: Study
8. ASCO: Younger colon cancer patients have worse prognosis at diagnosis, yet better survival
9. Just do it! not good enough for cancer patients, UR researchers say
10. Skin transplant offers new hope for vitiligo patients
11. Nordic Walking a Winner for Heart Failure Patients, Study Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... California (PRWEB) , ... May 03, 2016 , ... Cosmetic ... practice in late 2014, incorporating the injectable filler into his menu of services ... aesthetic transformation. Now, more than a year later, he’s still improving his approach to ...
(Date:5/3/2016)... FORT WORTH, Texas (PRWEB) , ... May 03, 2016 , ... ... some of the signs of pet anxiety. "Pet owners often think anxiety only ... be sending stress signals in other ways, and there’s things that be done about ...
(Date:5/3/2016)... Texas (PRWEB) , ... May 03, 2016 , ... ... today announced that it is launching a new client service center in La ... Houston, Texas, and will provide the full range of Empyrean client services. , ...
(Date:5/3/2016)... ... , ... Each year, about 800,000 people suffer from cerebral vascular accidents, or ... account for one death every four minutes. Many people who survive a stroke ... launching a video series called “Your Brain,” in conjunction with its medical journal “Balance,” ...
(Date:5/3/2016)... Indianapolis, IN (PRWEB) , ... May 03, 2016 ... ... employee benefits advisory organization, announces Benefits Alliance Insurance Services as the latest addition ... powerhouse Southern California-based Firm comprised of Partners Wayne Blasman, David Styles, and Paul ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... , May 2, 2016 ... to reach USD 11.1 billion by 2024, according ... Research, Inc. Major drivers of the sonography market ... areas and government recommendations for periodic ultrasound screenings ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) ...
(Date:4/29/2016)... , April 29, 2016 ... Review, H1 2016" market research report that provides ... with comparative analysis at various stages, therapeutics assessment ... of administration (RoA) and molecule type, along with ... It also reviews key players involved in the ...
(Date:4/29/2016)... 2016 Interview ... Sanofi, leader mondial et diversifié ... pour le premier trimestre 2016. Le ... commente les résultats du premier trimestre ... le reste de l,année. ...
Breaking Medicine Technology: