Navigation Links
Patients’ Immune System May Influence Immunotherapy
Date:4/2/2017

Higher or lower levels of certain immune cells in cancer patients may be associated with how well they respond to immunotherapy, according to preliminary results of a study conducted by researchers at the University of Pittsburgh Cancer Institute (UPCI).

The findings will be presented today at the American Association of Cancer Research (AACR) Annual Meeting in Washington, D.C., by Robert Ferris, M.D., Ph.D., UPMC Endowed Professor, chief of the Division of Head and Neck Surgery, and co-leader of the Cancer Immunology Program at UPCI.

The research was an extension of the recently completed CheckMate 141 Phase III clinical trial co-chaired by Dr. Ferris, which showed that the immunotherapy nivolumab significantly increases survival and causes fewer adverse side effects in patients with recurrent head and neck cancer.

However, the treatment was not equally effective in all the patients so Dr. Ferris and his team aimed to find out whether differences in the patients’ immune system profiles could be associated with better response to immunotherapy.

The researchers found that higher levels of tumor-associated immune cells (TAICs) expressing the PD-L1 protein were associated with longer overall survival and greater likelihood of response to the drug nivolumab. TAICs are immune cells that have infiltrated the tumor and are thought to play an important role in tumor growth.

In blood samples taken prior to the start of immunotherapy, the researchers also found that patients with higher levels of circulating CD8, or cytotoxic, T cells—also known as killer T cells—and lower levels of regulatory T cells were associated with better response to treatment.

“Our study shows that immune cells in the microenvironment around the tumor could play a critical role in how patients respond to immunotherapy. By determining the nature of these cells and how they are affected by treatments, we may be able to significantly improve the effectiveness of current therapies and help a greater number of patients,” said Dr. Ferris.

Additional U.S. institutions that participated in the CheckMate trial include Ohio State University, University of Texas MD Anderson Cancer Center, Stanford Cancer Institute, University of Chicago, Dana-Farber Cancer Institute and Bristol-Myers Squibb.

International collaborators are located at BC Cancer Agency in Canada; Centre Leon Berard, Centre Antoine Lacassagne, and Institut Gustave Roussy, all in France; Fondazione IRCCS Istituto Nazionale Tumori, and University of Milan in Italy; The Institute of Cancer Research, in the United Kingdom; University Hospital Essen, in Germany; Hospital Universitario 12 de Octubre, in Spain; University Hospital Zurich, in Switzerland; and National Cancer Center Hospital East in Japan.

This study was funded by UPCI and Bristol-Myers Squibb.

Read the full story at http://www.prweb.com/releases/2017/04/prweb14204710.htm.


'/>"/>
Source: PRWeb
Copyright©2017 Vocus, Inc.
All rights reserved


Related medicine news :

1. Physicians ‘Like’ Patients’ Efforts to Self-Educate Online, Notes Dr. Shirin Towfigh
2. NY Breast Reconstruction Associates Honor Patients’ Journeys at The Uplifting Event
3. Get Real Health’s CHBase™ Gives Healthcare Providers a 360° View of Patients’ Health
4. Patients’ Healthcare Partners Celebrated During National Case Management Week
5. 449 Recovery Joins the MAP Recovery Network to Track Outcomes Data and Improve Patients’ Long-term Recovery Rates
6. Pulmonary Hypertension Association Part of Coalition Supporting the Patients’ Access to Treatments Act
7. North Shore-LIJ Completes Last Phase of $50M Upgrade of its Diagnostic Imaging Systems, $12M for GE Low-Dose CT Scanners to Reduce Patients’ Radiation Exposure
8. University of Colorado Cancer Center Study Shows How to Keep Nanoparticle Caterpillars Safe From the Crows of the Immune System
9. Introducing Zen Air Immune Boost Diffuser Blend of Essential Oils, Joining the Popular Topical Blend from Sublime Naturals for Wellness.
10. Advanced Cell Diagnostics Webinar on Surveying Expression of Immune Checkpoint Markers in Tissue Microenvironment
11. Chronic Inflammation of Obesity, Autoimmune Conditions Leads to Imbalanced Blood System and Potential Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work to improve ... engagement.” The patient is doing more than filling out a survey; in many cases ... an increasing emphasis in health care and research on the importance of active engagement ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical ... the primary prevention of cardiovascular diseases during the 15th Annual Women’s Health ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults ... tested to meet the highest standard. , These products are also: Gluten ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017  DarioHealth ... and big data solutions, today announced that its MyDario product is expected ... local TV listings for when The Dr. Oz Show airs in your ... The nine-time Emmy ... ...
(Date:9/22/2017)... -- AVACEN Medical (AVACEN) announced that its CE-Marked AVACEN ... with the widespread pain associated with fibromyalgia in the ... Essex, England commented, "I had difficulty ... sleep at all, tremendous pain, with every movement sending ... AVACEN 100] enough, how this has and is helping ...
(Date:9/13/2017)... Sept. 13, 2017   OrthoAtlanta has been named ... Football Host Committee (AFHC) for the 2018 College Football Playoff ... 2018, at Mercedes-Benz Stadium in Atlanta, Georgia ... AFHC "I,m In" campaign, participating in many activities leading up ... ...
Breaking Medicine Technology: