Navigation Links
Patients treated with sunitinib and sorafenib respond to flu vaccine
Date:6/28/2011

PHILADELPHIA Patients treated with sunitinib and sorafenib responded to the flu vaccine, which suggests the agents do not damage the immune system as much as previously feared, according to a study in Clinical Cancer Research, a journal of the American Association for Cancer Research.

Keith Flaherty, M.D., director of developmental therapeutics at the Massachusetts General Hospital and a senior editor of Clinical Cancer Research, said the findings have broad implications beyond questions of patient management.

"The damage that chemotherapy does to normal, healthy cells as it treats cancer has been well documented, but the precise effect that the new class of targeted agents has on the immune system is less well known," he said. "This study helps us answer that question."

Flaherty said the indication that the flu vaccine is safe and effective in cancer patients treated with sunitinib and sorafenib, tyrosine kinase inhibitors that have been shown to have an effect on several types of cancer, suggests that clinicians can be less concerned about other targeted therapies.

"At the very least, it allows us to have a method of testing the capacity of the immune system when we use these agents, similar to how a stress test would test heart function," said Flaherty.

Flaherty cautioned, however, that the findings would have to be confirmed both with other tyrosine kinase inhibitors and with other classes of drugs. As a question of patient management, the effect is more conclusive, according to Flaherty.

The study, led by Carla van Herpen, M.D., Ph.D., a medical oncologist at Radboud University Nijmegen Medical Center in The Netherlands, included 40 patients: 16 were treated with sunitinib, six were treated with sorafenib, seven patients with metastatic renal cell cancer were treated with neither drug and 11 were healthy.

The researchers observed an antibody response in all patients comparable with healthy participants.

"The exact incidence of influenza in patients with cancer is not known, however, it is definitely higher than in the general population," said van Herpen. "Managing these patients with the flu vaccine would improve their quality of life."


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Innovative UBC-BC Cancer Agency system reduces waitlisting for chemotherapy patients
2. Team approach reduces urinary tract infections in rehab patients
3. Intensive, hands-on effort reduces bloodstream infections in critically ill patients
4. Surprising drop in physicians willingness to accept patients with insurance
5. Nearly Half of Older Breast Cancer Patients Dont Get Radiation
6. Many advanced breast cancer patients do not receive recommended treatment
7. In a new post-hoc analysis, significantly more patients achieved blood sugar goals with JANUMET
8. Heart valve replacement without opening the chest gives new option for non-operable patients
9. 200,000 patients treated for cardiac arrest annually in US hospitals, Penn study shows
10. Early Talk Therapy May Help Stroke Patients Bounce Back
11. Study: Long-term inhaled corticosteroid use increases fracture risk in lung disease patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2019)... ... , ... Cocoa Beach is preparing to host its 10th annual “Surfing Santas” ... , What began as a simple family beach day a decade ago has grown ... years in, there’s no better place for Santa to loosen up as he gets ...
(Date:12/6/2019)... ... December 06, 2019 , ... ... been recognized for excellence in employee learning. The Omaha-based company has been named ... with the most successful employer-sponsored training and development programs worldwide. Rankings of the ...
(Date:12/6/2019)... ... December 06, 2019 , ... Lasair Aesthetic Health Sponsors Toys for Tots to Give Free ... to Patients Who Bring in Toys During the Holidays , Lasair Aesthetic Health is spreading ... Christmas, patients who bring in a toy or toys worth more than 25-dollars, will get ...
(Date:12/5/2019)... ... December 05, 2019 , ... A cohort of ... technology to help their patients more easily detect ruptured silicone gel implants. Dr. ... study and reporting on his experience. While the FDA currently recommends regular MRI ...
(Date:12/5/2019)... ... December 05, 2019 , ... Today at M Health ... hospital's newest staff member who will to help them take medicine, relax during ... medical procedures.  , Rocket, presented by NutriSource® is a golden retriever and the ...
Breaking Medicine News(10 mins):
(Date:12/4/2019)... ... December 04, 2019 , ... ... announced the Top 17 Master's in Organizational Psychology Degree Programs for 2020. The ... universities in the nation. Each program is evaluated based on curriculum quality, graduation ...
(Date:12/2/2019)... ... ... Data integration has been a pharma industry buzzword for the last few years. ... are still working in silos and are not aware of all the data available ... and nearly one-third of qualified investigators may be overlooked. Innovations in data mapping and ...
(Date:12/2/2019)... PARK, Kan. (PRWEB) , ... December 02, 2019 ... ... Fertile XX, a nutritional supplement produced by Native Remedies aimed at supporting Women’s ... baby. Unfortunately, Mother Nature makes conception harder for some women than for others. ...
Breaking Medicine Technology: