Navigation Links
Patients treated with sunitinib and sorafenib respond to flu vaccine
Date:6/28/2011

PHILADELPHIA Patients treated with sunitinib and sorafenib responded to the flu vaccine, which suggests the agents do not damage the immune system as much as previously feared, according to a study in Clinical Cancer Research, a journal of the American Association for Cancer Research.

Keith Flaherty, M.D., director of developmental therapeutics at the Massachusetts General Hospital and a senior editor of Clinical Cancer Research, said the findings have broad implications beyond questions of patient management.

"The damage that chemotherapy does to normal, healthy cells as it treats cancer has been well documented, but the precise effect that the new class of targeted agents has on the immune system is less well known," he said. "This study helps us answer that question."

Flaherty said the indication that the flu vaccine is safe and effective in cancer patients treated with sunitinib and sorafenib, tyrosine kinase inhibitors that have been shown to have an effect on several types of cancer, suggests that clinicians can be less concerned about other targeted therapies.

"At the very least, it allows us to have a method of testing the capacity of the immune system when we use these agents, similar to how a stress test would test heart function," said Flaherty.

Flaherty cautioned, however, that the findings would have to be confirmed both with other tyrosine kinase inhibitors and with other classes of drugs. As a question of patient management, the effect is more conclusive, according to Flaherty.

The study, led by Carla van Herpen, M.D., Ph.D., a medical oncologist at Radboud University Nijmegen Medical Center in The Netherlands, included 40 patients: 16 were treated with sunitinib, six were treated with sorafenib, seven patients with metastatic renal cell cancer were treated with neither drug and 11 were healthy.

The researchers observed an antibody response in all patients comparable with healthy participants.

"The exact incidence of influenza in patients with cancer is not known, however, it is definitely higher than in the general population," said van Herpen. "Managing these patients with the flu vaccine would improve their quality of life."


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Innovative UBC-BC Cancer Agency system reduces waitlisting for chemotherapy patients
2. Team approach reduces urinary tract infections in rehab patients
3. Intensive, hands-on effort reduces bloodstream infections in critically ill patients
4. Surprising drop in physicians willingness to accept patients with insurance
5. Nearly Half of Older Breast Cancer Patients Dont Get Radiation
6. Many advanced breast cancer patients do not receive recommended treatment
7. In a new post-hoc analysis, significantly more patients achieved blood sugar goals with JANUMET
8. Heart valve replacement without opening the chest gives new option for non-operable patients
9. 200,000 patients treated for cardiac arrest annually in US hospitals, Penn study shows
10. Early Talk Therapy May Help Stroke Patients Bounce Back
11. Study: Long-term inhaled corticosteroid use increases fracture risk in lung disease patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... Adelberg-Montalvan ... dentistry options for its patients on Long Island, New York. , Holistic ... being, and is one of the biggest trends in dentistry today. , ...
(Date:5/24/2017)... ... May 24, 2017 , ... Fiberstar, Inc., ... the food and beverage industry offers Citri-Fi®, a natural citrus fiber, to improve ... decision process. As a result, labels need to deliver simple, transparent and clear ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... Clinical Integration company, announced today that its iClinic V12.2 solution has achieved approval ... NCQA recently introduced PCMH 2017 standards which emphasize team-based care with a ...
(Date:5/23/2017)... NY (PRWEB) , ... May 23, 2017 , ... ... in the pharmaceutical and medical device sectors, today announced the winners of its ... • Entrepreneurs) represent the most influential people in the healthcare industry today. , ...
(Date:5/23/2017)... ... May 23, 2017 , ... i2i Population Health, a national ... category winner, has named Daniel P. Bullington as chief technology officer. , “i2i ... and product offerings,” says Justin Neece, president. “Daniel is an excellent fit for ...
Breaking Medicine News(10 mins):
(Date:5/3/2017)...  Getinge, a leading global provider of products ... cost efficiency within healthcare and life sciences, today ... demonstrating that intra-aortic balloon counterpulsation (IABC) appears effective ... The single-center, retrospective, observational study showed that use ... 50cc intra-aortic balloon (IAB) in contemporary practice ...
(Date:5/2/2017)... and NEW YORK and ... As the leading distributor of market intelligence, MarketResearch.com is ... Med Tech Reimbursement Consulting AB that allows for ... Consulting AB,s proprietary market analyses through the MarketResearch.com website. ... the world easy access to complete product descriptions and ...
(Date:5/2/2017)... CORALVILLE, Iowa , May 2, 2017 /PRNewswire/ ... innovative, patient-centric radiotherapy solutions, announced today that ... has been with CIVCO since 2012 and has ... line management, senior vice president and general manager, ... manager. "I am extremely proud of ...
Breaking Medicine Technology: