Navigation Links
Patient's own infection-fighting T cells put late-stage melanoma into long-term remission
Date:6/18/2008

SEATTLE Researchers describe the first successful use of a human patient's cloned infection-fighting T cells as the sole therapy to put an advanced solid-tumor cancer into long-term remission. A team led by Cassian Yee, M.D., an associate member of the Clinical Research Division at Fred Hutchinson Cancer Research Center, reports these findings in the June 19 issue of the New England Journal of Medicine.

Yee and colleagues removed CD4+ T cells, a type of white blood cell, from a 52-year-old man whose Stage 4 melanoma had spread to a groin lymph node and to a lung. T cells specific to targeting the melanoma were then expanded vastly in the laboratory using modifications to existing methods. The lab-grown cells were then infused into the patient with no additional pre- or post-conditioning therapies, such as growth-factor or cytokine treatment. Two months later, PET and CT scans revealed no tumors. The patient remained disease free two years later, when he was last checked.

"We were surprised by the anti-tumor effect of these CD4 T cells and its duration of response," Yee said. "For this patient we were successful, but we would need to confirm the effectiveness of therapy in a larger study."

Yee cautioned that these results, presented in the journal's "Brief Report" section, represent only one patient with a specific type of immune system whose tumor cells expressed a specific antigen. More studies are needed to confirm the effectiveness of the experimental T-cell therapy. If proven successful in more patients, Yee predicted this therapy could be used for the 25 percent of all late-stage melanoma patients who have the same immune-system type and tumor antigen.

Using a patient's own immune system to combat cancer, called immunotherapy, is a growing area of research that aims to develop less-toxic cancer treatments than standard chemotherapy and radiation.

The patient in the journal report was one of nine patients
'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. World Renowned Hand Surgeon Helps Patients Conquer Joint Discomfort Naturally
2. FDA Panel Recommends Enbrel for Pediatric Patients
3. FDA approves NeuRx diaphragm pacing system for use in spinal cord- injured patients
4. Medicsight ColonCAD Technology Successfully Identified Cancer in 100% of Patients Included in Data Presented at ESGAR 2008
5. Patient Data Analysis Report Finds More Than 75 Percent of Chronically Ill Patients Unable to Obtain Needed Healthcare Have Some Form of Insurance
6. Decatur Memorial Hospital Becomes First in Illinois to Treat Cancer Patients With RapidArc(TM) Radiotherapy Technology
7. Long-Term Safety Data on Lialda(TM) (mesalamine) for Patients With Ulcerative Colitis Published in Leading GI Journal
8. Same-day pregnancy test provides valuable guidance to pre-surgery patients
9. Future hope for patients with breast cancers resistant to tamoxifen
10. Some patients may not need insulin for long-term control of type 2 diabetes
11. Nurses, Doctors, Patients to Protest Health Insurers at National Day of Action - June 19th
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... Today, Dylan Queen, a renowned brand ... wedding dresses; the business offers a wide range of ... ladies worldwide, allowing them to create multiple looks easily. ... this new collection of chic wedding dresses has been ... offered at discounted rates now. Dylan Queen can always ...
(Date:11/22/2014)... Discount-Dress.com is an important company in ... to increase the company’s online market share by a series ... bridesmaid dresses and announced a bridesmaid dress promotion for the ... 30, 2014. All the dresses from this company are not ... fact, Discount-Dress.com is very good at manufacturing wedding dresses. Customers ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 "My friend ... pain caused by the machine," said an inventor from ... had to go back a second time because the ... idea." , She developed the patent-pending MAMO EASY to ... cancer. The design saves the patient from the pain ...
(Date:11/22/2014)... 22, 2014 (HealthDay News) -- The wide variety and ... a threat for people with food allergies, an expert ... so many types of food allergies that it can ... holidays," Dr. Guha Krishnaswamy, director of allergy and clinical ... a hospital news release. "If you know you ...
(Date:11/22/2014)... This month has been a historical time for ... many positive reviews from some renowned review websites. Recently, the ... launching a new selection of wonderful sexy wedding dresses to ... free shipping and up to an 80% discount on any ... find the most suitable dress at Angeldress.co.uk, which has garnered ...
Breaking Medicine News(10 mins):Health News:Dylan Queen Introduces Its New Wedding Dresses 2Health News:Bridesmaid Dresses Introduced by Famous Company Discount-Dress.com For The New Year 2015 2Health News:'Tis the Season of Challenges for Those With Food Allergies 2Health News:Sexy Wedding Dresses with Special Discounts Launched by Angeldress.co.uk 2
... in collaboration with,Siemens(R), AxisThree(R), Inc. of Pacific Palisades, ... Technology into the,Plastic Surgery office of Dr. Steve ... XS-300(TM), is the first of its kind, and ... combined with,innovative proprietary software. The XS-300(TM) platform photographs ...
... launch of its redesigned web site at www.oci.com , ... ... to meet the needs of its customers and target market, OCI is ... The site features improved content, an enhanced look and feel, and easy ...
... percent savings on medical services and healthcare products. , ... ... -- Allsup announced today it is offering a new http://www.allsup.com/Health-Discount-Program.aspx/?=PRJ2 ... of people with disabilities gain access to discounted healthcare and ...
... prescription drug samples distributed to children may be unsafe, ... Alliance and Hasbro Children,s Hospital. The national study, the ... children, appears in the October 2008 issue of ... as researchers at Harvard Medical School and the Warren ...
... long way toward helping severely obese individuals improve their ... to researchers at the Duke Diet and Fitness Center. ... average, just under one hour of exercise per week, ... life. They also reported improvements in their ability to ...
... Extendicare Skilled Nursing Facilities Named In Wash. Lawsuit, ... with,additional allegations in the class action lawsuit against ... the state of Washington [see,list by city at ... in,United States District Court, Western Washington Division, in ...
Cached Medicine News:Health News:Plan Your Breasts in 3-D 2Health News:Information Management Solutions Provider OCI Announces Redesign of Corporate Web Site 2Health News:Allsup Introduces Health Discount Program to Millions of People with Disabilities 2Health News:Allsup Introduces Health Discount Program to Millions of People with Disabilities 3Health News:Free drug samples carry risks for children 2Health News:A little exercise goes a long way for severely obese 2Health News:Additional Allegations Filed Against Elder Care Operator 2Health News:Additional Allegations Filed Against Elder Care Operator 3Health News:Additional Allegations Filed Against Elder Care Operator 4Health News:Additional Allegations Filed Against Elder Care Operator 5
(Date:11/21/2014)... /PRNewswire/-- CANTEL MEDICAL CORP. (NYSE: CMN ) announced today ... be presenting at the 26 th Annual Piper Jaffray ... New York . The formal presentation is scheduled ... addition, Mr. Krakauer and Jorgen B. Hansen , President ... the day. An audio webcast will be ...
(Date:11/21/2014)... /CNW Telbec/ - KLOX Technologies Inc. ("KLOX" or the ... Todd Martensen has been hired ... of Chief Commercial Officer, to oversee KLOX,s commercial launch ... for the treatment of chronic and other hard-to-heal wounds, ... in Europe . Mr. Martensen, a ...
(Date:11/21/2014)... , 21. November 2014 Michael ... sich am Morgen des 14. Februar 2014 zugetragen hat. ... wohl kaum vergessen. Video - http://youtu.be/5cVoMCe0uiE ... ich dabei war, mein morgendliches Training zu machen", erzählt ... zu der Zeit begeisterte Anhänger der CrossFit-Trainingsmethode. ...
Breaking Medicine Technology:KLOX Technologies announces executive appointments 2KLOX Technologies announces executive appointments 3KLOX Technologies announces executive appointments 4Tochter rettet Vater durch Herz-Lungen-Wiederbelebung vor plötzlichem Herztod 2Tochter rettet Vater durch Herz-Lungen-Wiederbelebung vor plötzlichem Herztod 3
... YORK, Oct. 25 See video from Novartis: ... New Phase III data indicate that ... conjugate vaccine) demonstrated robust immunogenicity in infants potentially ... disease 1, 3. These data were presented during ...
... Singapore company Novus Scientific Pte. Ltd today announced that ... the first patient in its groundbreaking study: Abdominal ... Flap - Comparison of TIGR® Matrix ... involving 86 patients, received DSRB approval on 9th September ...
Cached Medicine Technology:National University Hospital Singapore Operates on Asia's 1st TRAM Flap Patient Using TIGR® Matrix Surgical Mesh, the World's 1st Long-Term Resorbable Mesh 2National University Hospital Singapore Operates on Asia's 1st TRAM Flap Patient Using TIGR® Matrix Surgical Mesh, the World's 1st Long-Term Resorbable Mesh 3
New! Visually superior, micrometer handle, single foot plate, blade extends to 3.0 mm....
... is effective against gram positive and gram ... interfering with bacterial protein synthesis by binding ... suggested working concentration of 50 mg/L is ... thereby making a gentler alternative to penicillin ...
The double beveled oblique blade provides a true, straight incision. Penetrating through Bowman's and Descemet's membranes without inducing corneal distortion. No need to "Dimple Down"....
... The Boomerang ClosureWire Vascular Closure System ... Arteriotomy Site-Specific Compression., ,The Boomerang ClosureWire ... the inside of the arteriotomy and ... in a targeted internal compression of ...
Medicine Products: