Navigation Links
Patients' Skin Cells Yield Research Model for Alzheimer's

MONDAY, July 16 (HealthDay News) -- Aiming for insights into Alzheimer's disease, scientists have developed a new cellular model for research -- one that's sourced from the skin cells of patients but genetically reprogrammed to mimic diseased brain cells.

The scientists say their approach might draw on the stem cells of people with Alzheimer's disease as a virtually limitless supply of different types of diseased brain cells for laboratory study.

The results were to be presented Monday at the Alzheimer's Association annual meeting in Vancouver.

Theoretically, the innovation could improve upon the current method of study, which primarily relies on mouse-based models. Researchers say that such animal research, while often fruitful, falls short of fully representing the disease environment found in human patients.

"Current animal models of Alzheimer's are highly engineered to express elements of the disease and, while valuable for research, incompletely represent how the disease forms and progresses in people," William Thies, chief medical and scientific officer for the Alzheimer's Association, said in a news release from the meeting's organizers.

"In order to develop better therapies and eventually prevent Alzheimer's, we need better, more accurate animal and cellular models of the disease," Thies added. "This newly reported research is a significant step forward in that direction."

The study was led by Andrew Sproul, a postdoctoral associate at the New York Stem Cell Foundation in New York City. Sproul and his colleagues noted that the telltale amyloid protein plaques that build up in the brains of human Alzheimer's patients also differ from those found in mice.

With that in mind, the authors worked with cells from 12 Alzheimer's patients along with several healthy family members. All the patients had been diagnosed with the most common form of a rare type of an early-onset form of Alzheimer's disease (representing just 2 percent of all cases) that is known to be inherited.

After extracting skin cells from the study participants, the team used genetic engineering to prod the cells into developing into several kinds of "electrically active" brain cells -- forebrain nerve cells, neural stem cells and glial cells.

The team noted that because most Alzheimer's patients suffer from a different, late-onset type of disease, more work will have to be done to broaden this new approach so that it covers that form of the disease.

"Over the next few years, we expect to provide substantial insight into Alzheimer's and valuable tools to help create the next generation of therapeutics," Sproul noted.

Research presented at medical meetings is typically considered preliminary until published in a peer-reviewed journal.

More information

For more on Alzheimer's disease, visit the U.S. National Institute on Aging.

-- Alan Mozes

SOURCE: Alzheimer's Association International Conference 2012, July 16, 2012

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Higher-spending hospitals have fewer deaths for emergency patients
2. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
3. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
4. Study finds doctors have exaggerated fears when starting patients on insulin
5. Diagnostic Scans Tied to Radiation Risk for Gastro Patients
6. Predictors identified for rehospitalization among post-acute stroke patients
7. Pulse pressure elevation could presage cerebrovascular disease in Alzheimers patients
8. Breast cancer patients suffer treatment-related side effects long after completing care
9. Heart failure patients with diabetes may benefit from higher glucose levels
10. Gastro Woes Often Strike Rheumatoid Arthritis Patients
11. Short Walks May Ease Fatigue in Pancreatic Cancer Patients
Post Your Comments:
Related Image:
Patients' Skin Cells Yield Research Model for Alzheimer's 
(Date:6/26/2016)... ... ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center for ... Table in Battle Creek, MI, where the rehabilitation facility is located. This annual celebration ... world’s leading providers of cereal and other breakfast foods. Its residents often refer to ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... "With 30 ... their specific project," said Christina Austin - CEO of Pixel Film Studios. , ... and all within Final Cut Pro X . Simply select a ProHand generator ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Global MEMS Devices Medical Market Analysis 2016 - Forecast to ... The report contains up to date financial ... reliable analysis. Assessment of major trends with potential impact on ... dive analysis of market segmentation which comprises of sub markets, ...
(Date:6/23/2016)... , June 23, 2016 Bracket , ... launch its next generation clinical outcomes platform, Bracket eCOA (SM) ... held on June 26 – 30, 2016 in ... first electronic Clinical Outcome Assessment product of its kind to ... #715. Bracket eCOA 6.0 is a flexible platform ...
Breaking Medicine Technology: