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Patient Enrollment Completed in Phase IIb Trial of EpiCept(TM) NP-1 in Diabetic Peripheral Neuropathy
Date:12/2/2007

he NP-1 trial in DPN, there are two other clinical trials for NP-1 currently underway.

-- A Phase III trial in chemotherapy-induced peripheral neuropathy (CPN)

is being conducted by the National Cancer Institute (NCI)-funded

Community Clinical Oncology Program. The double-blind, randomized

placebo-controlled study includes approximately 400 patients suffering

from painful CPN for at least 28 days following the conclusion of

chemotherapy. The primary endpoint of the 12-week trial is change in

average daily pain intensity scores from baseline to the endpoint.

This trial is currently enrolling patients.

-- A Phase IIb trial is underway in peripheral herpetic neuropathy. This

500-patient, placebo- and active-controlled trial will compare the

efficacy and safety of NP-1 vs. gabapentin and placebo. The primary

endpoint for this trial is the change in pain intensity over the four-

week duration of the trial. Preliminary results are expected early in

the second quarter of 2008.

About EpiCept Corporation

EpiCept is focused on unmet needs in the treatment of pain and cancer. The Company's broad portfolio of pharmaceutical product candidates includes several pain therapies in clinical development and a lead oncology compound for AML with demonstrated efficacy in a Phase III trial; a marketing authorization application for this compound is approaching a decision in Europe. In addition, EpiCept's ASAP technology, a proprietary live cell high- throughput caspase-3 screening technology, can efficiently identify new cancer drug candidates and molecular targets that selectively induce apoptosis in cancer cells. Two oncology drug candidates currently in clinical development that were discovered using this technology have also been shown to act as vascular disruption agents in a variety of solid tumors.

Forward-Looking Statements

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