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Pathwork Tissue of Origin Test Validation Study Published in Journal of Clinical Oncology
Date:3/30/2009

tic, poorly differentiated or undifferentiated. The test demonstrated 88% positive percent agreement (akin to sensitivity) and greater than 99% negative percent agreement (akin to specificity) with available diagnoses. Although the JCO paper only reported results for frozen tissue samples, a separate validation study performed by Pathwork with FFPE (formalin-fixed, paraffin-embedded) specimens showed similar performance. Both the frozen and FFPE versions of the test are commercially available as a service through Pathwork Diagnostics Laboratory.

The paper published in the American Society of Clinical Oncology's journal was authored by Federico Monzon, M.D., Director of Molecular Diagnostics at The Methodist Hospital in Houston, Texas. Dr. Monzon's results showed that the test should become a valuable complement to currently available diagnostic methods for tumors with uncertain origins. The abstract can be read online at http://jco.ascopubs.org/ and the full paper is available for download on www.pathworkdx.com.

About Pathwork Diagnostics

Pathwork Diagnostics, Inc., based in Redwood City, Calif., develops and commercializes high-value molecular diagnostics for oncology. The company's first test to market - the Pathwork(R) Tissue of Origin Test - utilizes proprietary analytics and a companion Pathchip(R) microarray, which runs on the proven Affymetrix GeneChip(R) System. For more information, call 1.877.808.0006 or visit www.pathworkdx.com.

Copyright (C) 2009 Pathwork Diagnostics, Inc. All rights reserved. Pathwork, Pathchip, Pathwork Diagnostics, and the Pathwork Diagnostics and the Pathwork Tissue of Origin logos are trademarks or registered trademarks of
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SOURCE Pathwork Diagnostics, Inc.
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