Navigation Links
Pathwork Tissue of Origin Test Validation Study Published in Journal of Clinical Oncology

Largest Study on a Test that Identifies Tumors with Uncertain Origins Demonstrates Unmatched Performance

REDWOOD CITY, Calif., March 30 /PRNewswire/ -- Pathwork Diagnostics, Inc., a molecular diagnostics company focused on oncology, announced today that the Journal of Clinical Oncology (JCO) has published the results of the Pathwork(R) Tissue of Origin Test validation study in a paper entitled, "Multicenter Validation of a 1,550-Gene Expression Profile for Identification of Tumor Tissue of Origin." The results of the 547-specimen study showed that the test has significant potential to reduce diagnostic uncertainty for poorly differentiated, undifferentiated or metastatic tumors. To date, no other tests in this category have undergone as large a clinical validation study or produced such strong results.

"This study, which is the first of many clinical studies being performed, clearly demonstrates the exceptional performance and robust science underlying our test," said Deborah J. Neff, President and Chief Executive Officer of Pathwork Diagnostics. "We believe the Tissue of Origin Test can benefit physicians by allowing them to diagnose tumors with uncertain origins with greater confidence because the test provides objective data and the ability to both rule in and rule out tumor types."

To determine the tumor's origin, the Pathwork Tissue of Origin Test uses microarray technology to measure the gene expression pattern, comprising more than 1,500 genes, in a tumor with an uncertain origin and compare it to expression patterns of a panel of 15 known tumor types, representing 90 percent of all solid tumors and 58 morphologies overall. In the multicenter, blinded clinical validation study, which was used as the basis for the test's FDA clearance in July 2008, the test examined 547 frozen tumor specimens from patients diagnosed with one of the tumor types in the panel, all of which were either metastatic, poorly differentiated or undifferentiated. The test demonstrated 88% positive percent agreement (akin to sensitivity) and greater than 99% negative percent agreement (akin to specificity) with available diagnoses. Although the JCO paper only reported results for frozen tissue samples, a separate validation study performed by Pathwork with FFPE (formalin-fixed, paraffin-embedded) specimens showed similar performance. Both the frozen and FFPE versions of the test are commercially available as a service through Pathwork Diagnostics Laboratory.

The paper published in the American Society of Clinical Oncology's journal was authored by Federico Monzon, M.D., Director of Molecular Diagnostics at The Methodist Hospital in Houston, Texas. Dr. Monzon's results showed that the test should become a valuable complement to currently available diagnostic methods for tumors with uncertain origins. The abstract can be read online at and the full paper is available for download on

About Pathwork Diagnostics

Pathwork Diagnostics, Inc., based in Redwood City, Calif., develops and commercializes high-value molecular diagnostics for oncology. The company's first test to market - the Pathwork(R) Tissue of Origin Test - utilizes proprietary analytics and a companion Pathchip(R) microarray, which runs on the proven Affymetrix GeneChip(R) System. For more information, call 1.877.808.0006 or visit

Copyright (C) 2009 Pathwork Diagnostics, Inc. All rights reserved. Pathwork, Pathchip, Pathwork Diagnostics, and the Pathwork Diagnostics and the Pathwork Tissue of Origin logos are trademarks or registered trademarks of Pathwork Diagnostics, Inc. Other names may be the trademarks of their respective owners.

    Jane Woo

SOURCE Pathwork Diagnostics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Studies Investigate Diagnostic Performance and Reproducibility of Pathwork Diagnostics Tissue of Origin Test
2. Pathwork Tissue of Origin Test Shows Potential to Aid in the Diagnosis of Cancer of Unknown Primary
3. Pathwork Diagnostics Collaborates With Guys and St Thomas on Tissue of Origin Test Validation in the UK
4. Pathwork Diagnostics Launches Version of Its Tissue of Origin Test for FFPE Specimens
5. Donate Life America Dispels Myths About Organ & Tissue Donation Among Hispanics During National Hispanic Heritage Month
6. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
7. Stem cells derived from adult testes produce wide range of tissue types
8. Stem Cells From Testes Produce Wide Range of Tissue Types
9. Tissue-Growth Gene Tied to Scleroderma
10. Two Million Californians Say Yes! to Organ and Tissue Donation
11. Starion Instruments Launches Next-Generation Tissue Ligating Shears at the American College of Surgeons Clinical Congress
Post Your Comments:
(Date:6/26/2016)... ... ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect Plugin ... whole new perspective by using the title layers in ProSlice Levels to split-up ... Levels contains over 30 Different presets to choose from. FCPX users can ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... 25, 2016 , ... Dr. Calvin Johnson has dedicated his ... implemented orthobiologic procedures as a method for treating his patients. The procedure is ... to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to help ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... San Diego, CA (PRWEB) , ... June 24, 2016 , ... ... up with the American Cancer Society and the Road To Recovery® program to drive ... care to seniors and other adults to ensure the highest quality of life and ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in Bogota. Colombia ... ... Sandra ... ... Astellas is a pharmaceutical company ...
(Date:6/23/2016)... 2016 The vast majority of dialysis patients ... Treatments are usually 3 times a week, with treatment ... travel time, equipment preparation and wait time.  This regimen ... for patients who are elderly and frail.  Many elderly ... rehabilitation centers for some duration of time. ...
(Date:6/23/2016)... June 23, 2016 The Biotechnology ... continues to present great opportunities to investors. assesses ... Intrexon Corp. (NYSE: XON ), Vertex Pharmaceuticals ... (NASDAQ: ARNA ), and Regeneron Pharmaceuticals Inc. ... stocks and receive your complimentary trade alerts at: ...
Breaking Medicine Technology: