Navigation Links
Pathway to cell death redefined in landmark study
Date:9/21/2007

PITTSBURGH, Sept. 20 -- A new study led by investigators from the University of Pittsburgh School of Medicine demonstrates that the process of necrosis, long thought to be a chaotic, irreversible pathway to cell death, may actually be triggered as part of a regulated response to stress by a powerful protein, SRP-6, that can potentially halt necrosis in its path. Further, the research team realized that this protein might be harnessed to direct some cells -- those in cancerous tumors, for instance -- to die, while saving others, such as degenerating neural cells responsible for Alzheimers and Parkinsons diseases. The work appears on the Sept. 21 cover of the journal Cell.

This remarkable molecular trigger, SRP-6, is a serine protease inhibitor or serpin, and targets the cells digestive center, the lysosome. The authors report that the family of intracellular serpins may help cells survive in the face of stressors by protecting against lysosomal injury and its cellular consequences.

For years, we believed that cell death related to a catastrophic insult such as a stroke or heart attack that deprives tissue of oxygen couldnt really be treated, so we focused on strategies to prevent further damage by restoring blood flow as quickly as possible with clot busters and surgery, said Gary A. Silverman, M.D., Ph.D., chief of newborn medicine in the department of pediatrics at the Pitt School of Medicine and the studys senior author. But our research indicates that necrosis can be interrupted and possibly repaired, even after the injury process is well underway. This insight has exciting implications for the management of heart disease, stroke and neurological illnesses.

Representing more than five years of study, the Cell publication is the result of a chance observation made by primary author Cliff J. Luke, Ph.D., assistant professor of pediatrics at Pitt and an investigator at the university-affiliated Magee-Womens Research Institute. Drs. L
'/>"/>

Contact: Michele Baum
BaumMD@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Expose on eating disorders!! Scientists trace “brain’s eating control center pathway”
2. Scientists Identify Cancer Pathway
3. Citrinin, a fungal toxin, induces apoptosis via mitochondrial pathway
4. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
5. Mice model to study bacterial therapeutic pathway
6. Unchecked Cellular Repair Pathway Causes Liver Cancer
7. Lack of Funds in Sudan-Pathway to Epidemic Outbreaks
8. Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss
9. Birth Defects Caused By Deficiencies In Cell Signaling Pathway
10. Discovery of A New Genetic Pathway Could Lead To Treatment Of Skin Problems And Cancer
11. Cellular Pathway Yields Potential New Weapon in Vaccine Arsenal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Va. (PRWEB) January 22, 2015 Liberty University ... Counseling (M.A.) program from the Council for Accreditation ... program, part of Liberty’s Center for Counseling & Family ... founding dean of the university’s new School of Behavioral Sciences. ...
(Date:1/22/2015)... Padre Murphy's and Owner Tom Boyle in Glendale, AZ ... Alliance (PPHA). The PPHA's passion for others' well-being and ... greats, treated for obstructive sleep apnea (OSA) has propelled them ... in the valley. The most recent plans for an event ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 AngelWeddingDress, the ... of 2015 maternity wedding dresses. View website ... are looking for maternity wedding dresses online for a ... gowns with high quality for them. Its maternity wedding ...
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post ... insurance policy . , Auto insurance quotes help many ... no longer necessary to call an agent or visit an ... on a single website: http://autocarinsurancebest.com/ . , Every business ...
(Date:1/22/2015)... 2015 Yesterday, Senator Holly Mitchell ... Kristin Olsen (R-Modesto) were honored by the California ... biotechnology, biomedical science, medical device and pharmaceutical innovation ... the “2014 Life Sciences Champion” award from CHI ...
Breaking Medicine News(10 mins):Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3
... The American Heart,Association recognized several distinguished volunteers and ... The Cure on the Hill Awards Luncheon" and,"Gold ... association presented its Gold Heart Award to Coletta ... O. Grant, M.D., Ph.D.,and Reginald L. Washington, M.D. ...
... Pauletta and Denzel Washington will present two research ... in Denzels hometown of Mount Vernon, N.Y. The ceremony ... Denzel Washington Family Scholar in Neuroscience Awards have been ... at Cedars-Sinai Medical Center in Los Angeles. The program ...
... Bamberg, Calhoun, Chester, Kershaw, Lancaster, Lexington, Orangeburg, Richland, Sumter and ... ... COLUMBIA, S.C., April 30 BlueCross,BlueShield of South Carolina and WellPoint ... Carolina Department of Health and Human Services,to offer Medicaid benefits to ...
... Visualization Solutions Has Become Worldwide Imaging, ... Collaboration, MINNEAPOLIS, April 30 Vital Images, ... enterprise-wide advanced,visualization and analysis solutions, has surpassed the ... more users,worldwide of advanced visualization software solutions., ...
... a gastric juice PCR test for the detection of H. ... with histology and gastric biopsy PCR. , This study, led ... to be published in the March 14, 2008, issue of ... is a gram-negative spiral bacterium that infects the human gastric ...
... a number of researchers who are searching for useful ... as an effective target in clinical therapy. Hb3 is ... laboratory, and whose sensitivity and specificity are superior to ... may be useful in the clinical diagnosis of colorectal ...
Cached Medicine News:Health News:Association Honors Top Volunteers, Staff Member at Washington, D.C. Meeting 2Health News:Association Honors Top Volunteers, Staff Member at Washington, D.C. Meeting 3Health News:Denzel Washington's hometown hosts awarding of scholarships bearing Washington family name 2Health News:Denzel Washington's hometown hosts awarding of scholarships bearing Washington family name 3Health News:BlueCross BlueShield of South Carolina and WellPoint Affiliate Receive State Approval for Ten South Carolina Counties 2Health News:BlueCross BlueShield of South Carolina and WellPoint Affiliate Receive State Approval for Ten South Carolina Counties 3Health News:Vital Images Surpasses 3,000 Customer Sites Worldwide 2Health News:Vital Images Surpasses 3,000 Customer Sites Worldwide 3Health News:Monoclonal antibody Hb3: A marker for colon cancer progression or as a therapeutic target? 2
(Date:1/22/2015)... 2015  Amgen (NASDAQ: AMGN ) today announced that it ... on Tuesday, Jan. 27, 2015, after the close of the U.S. ... with the investment community at 2 p.m. PT. Participating in the ... and chief executive officer, and other members of Amgen,s senior management ...
(Date:1/22/2015)... , Jan. 22, 2015 Increasing sophistication among ... consolidation of localization purchasing in 2015, says Moravia ... to a recent study by market research firm Common ... single-source solution for their translation and localization needs. "From ...
(Date:1/22/2015)... Markets ( http://www.researchandmarkets.com/research/w25xpc/allergy ) has announced the addition ... & by End User - Global Forecast to 2019" ... diagnostics market is valued at $1,228.58 million in 2014 and ... reach $2,230.72 million by 2019. Allergy diagnostics is used to ...
Breaking Medicine Technology:Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Moravia Sees Single-Sourcing as Key Localization Trend in 2015 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 2Global Allergy Diagnostics (Immunoassay Analyzer, Luminometer, Assay Kit, Consumables) Market - Forecast to 2019 3
... announces that a new market research report is ... Global Medical Imaging Equipment Services Industry ... report analyzes the worldwide markets for Medical Imaging ... Product segments: OEM (Original Equipment Manufacturer), and Other ...
... NEW YORK, Feb. 23, 2011 Reportlinker.com announces ... in its catalogue: Global ... http://www.reportlinker.com/p092536/Global-Hematology-Instruments-and-Reagents-Industry.html This report ... Reagents in US$ Million by the following Product ...
Cached Medicine Technology:Reportlinker Adds Global Medical Imaging Equipment Services Industry 2Reportlinker Adds Global Hematology Instruments and Reagents Industry 2
... knee and hip. MOST Options is an ... and hip that provides the surgeon maximum ... selection, connection choice and fixation to match ... the needs of patients with minimal to ...
... has been shown to produce the highest ... any fixed bearing component. This combination of ... under loading minimizes the risk of polyethylene ... universal symmetrical component design streamlines inventory requirements ...
The AGC dual articular knee is indicated for severe primary or revision cases and features a patented unique articulation which allows controlled rotation of the femoral component about a central piv...
The NexGen CR femoral component is intended for patients who, in the physician's judgement, have good bone stock and whose ligaments provide adequate mediolateral, anteroposterior, and varus/valgus s...
Medicine Products: