Navigation Links
Pathway to cell death redefined in landmark study
Date:9/20/2007

PITTSBURGH, Sept. 20 -- A new study led by investigators from the University of Pittsburgh School of Medicine demonstrates that the process of necrosis, long thought to be a chaotic, irreversible pathway to cell death, may actually be triggered as part of a regulated response to stress by a powerful protein, SRP-6, that can potentially halt necrosis in its path. Further, the research team realized that this protein might be harnessed to direct some cells -- those in cancerous tumors, for instance -- to die, while saving others, such as degenerating neural cells responsible for Alzheimers and Parkinsons diseases. The work appears on the Sept. 21 cover of the journal Cell.

This remarkable molecular trigger, SRP-6, is a serine protease inhibitor or serpin, and targets the cells digestive center, the lysosome. The authors report that the family of intracellular serpins may help cells survive in the face of stressors by protecting against lysosomal injury and its cellular consequences.

For years, we believed that cell death related to a catastrophic insult such as a stroke or heart attack that deprives tissue of oxygen couldnt really be treated, so we focused on strategies to prevent further damage by restoring blood flow as quickly as possible with clot busters and surgery, said Gary A. Silverman, M.D., Ph.D., chief of newborn medicine in the department of pediatrics at the Pitt School of Medicine and the studys senior author. But our research indicates that necrosis can be interrupted and possibly repaired, even after the injury process is well underway. This insight has exciting implications for the management of heart disease, stroke and neurological illnesses.

Representing more than five years of study, the Cell publication is the result of a chance observation made by primary author Cliff J. Luke, Ph.D., assistant professor of pediatrics at Pitt and an investigator at the university-affiliated Magee-Womens Research Institute. Drs. L
'/>"/>

Contact: Michele Baum
BaumMD@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Expose on eating disorders!! Scientists trace “brain’s eating control center pathway”
2. Scientists Identify Cancer Pathway
3. Citrinin, a fungal toxin, induces apoptosis via mitochondrial pathway
4. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
5. Mice model to study bacterial therapeutic pathway
6. Unchecked Cellular Repair Pathway Causes Liver Cancer
7. Lack of Funds in Sudan-Pathway to Epidemic Outbreaks
8. Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss
9. Birth Defects Caused By Deficiencies In Cell Signaling Pathway
10. Discovery of A New Genetic Pathway Could Lead To Treatment Of Skin Problems And Cancer
11. Cellular Pathway Yields Potential New Weapon in Vaccine Arsenal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... Dennis Thompson HealthDay ... There,s good news about the experimental Ebola vaccine that U.S. ... research shows a precursor of that vaccine produced a ... version of the vaccine, when given to more than 100 ... and white blood cells that could potentially protect a person ...
(Date:12/24/2014)... Dec. 23, 2014 (HealthDay News) -- Long-term fear of terrorists ... early death, a new study from Israel suggests. , , ... study involved 17,300 Israelis. In Israel, the threat of war ... than 60 years. "We wanted to test whether fear ... increased risk of death," study author Hermona Soreq, a professor ...
(Date:12/24/2014)... -- If you are a high-risk heart patient, you ... by a cardiologist, new research suggests. Survival rates ... for annual professional meetings, Harvard researchers report. Sixty ... to a teaching hospital during one of these meetings ... these meetings were not taking place. "That,s a ...
(Date:12/22/2014)... 2014 As early as thirty, gravity ... in the form of “jowls." The dreaded droopiness usually ... the marionette line or smile lines. Aging can be ... but as the deep facial tissues descend, jowls inevitably ... fillers that can be used under the skin to ...
(Date:12/22/2014)... Sagacious Consultants, the premier full-service Epic consulting ... their ad hoc report writing service to meet the ... up for an annual subscription and get a fixed ... deeply discounted hourly rate. , Customers can choose ... discounted rate. Subscription hours are contracted in 25 hour ...
Breaking Medicine News(10 mins):Health News:Early Study Offers Hope for an Ebola Vaccine 2Health News:Early Study Offers Hope for an Ebola Vaccine 3Health News:Early Study Offers Hope for an Ebola Vaccine 4Health News:Terrorism Fears May Shorten Your Life, Study Finds 2Health News:When Heart Docs Are Away, Their High-Risk Patients May Fare Better 2Health News:When Heart Docs Are Away, Their High-Risk Patients May Fare Better 3Health News:Sam Rizk, MD, FACS, Introduces Rapid Recovery Facelift 2Health News:Sagacious Consultants’ New Subscription Packages Offer Customers Additional Report Writing Options 2Health News:Sagacious Consultants’ New Subscription Packages Offer Customers Additional Report Writing Options 3
... Speaker Nancy Pelosi,delivered remarks this morning at the ... members of Congress, and hundreds of,children and seniors. ... full,funding of the State Children,s Health Insurance Program ... ask me what the three most important issues ...
... BETHESDA, Md., Sept. 6 Montana native and health ... Center Billings, MT, has been,installed to the post ... Health Centers (NACHC). Ceremonies took place at NACHC,s ... in Dallas, TX,which drew thousands of health center ...
... to make open-heart,surgery a minimally invasive procedure ... of Health Bioengineering Research Partnership award.,Professor Pierre ... surgeon Pedro del Nido, M.D., at Children,s ... Inc. (Van Nuys,CA) will collaborate to develop ...
... finds it brings the patient real benefit, too , ... partners with Alzheimer,s disease report better physical health if ... shows. , "Preserving the health of spouse caregivers through ... disease, as caregivers who are in poor health are ...
... 6 In response to,reports about the potential closure ... today reassured employees that the,civil section of the facility ... of closing the civil section of Warren,State Hospital and ... in,which residents and counties have come to depend," said ...
... on most common cause of inherited mental ... impairment and Parkinson-like syndrome, SAN FRANCISCO, ... California, Davis, School of Medicine and the M.I.N.D.,Institute, in collaboration ... Interdisciplinary Research Consortium grant from,the National Institutes of Heath, the ...
Cached Medicine News:Health News:Pelosi: SCHIP Bill a Giant Step for America's Children 2Health News:Montana Health Care Leader Elected Board Chair of National Association 2Health News:Minimally Invasive Heart Surgery Research Wins N.I.H. Award 2Health News:Counseling Boosts Alzheimer's Caregivers' Health 2Health News:PA Secretary of Public Welfare Responds to Warren State Hospital Closure Rumors 2Health News:$21.8 Million NIH Grant for Fragile X Research 2Health News:$21.8 Million NIH Grant for Fragile X Research 3Health News:$21.8 Million NIH Grant for Fragile X Research 4
(Date:12/22/2014)... VIEJO, Calif. , Dec. 22, 2014 ... into expanded corporate offices in Aliso Viejo ... announced that due to the tremendous growth and worldwide ... needed. Sales of patented SnoreRx, the anti snore cure ... offices. He said, "We are now in 23 ...
(Date:12/22/2014)... 2014   TRU-D SmartUVC LLC, producers of ... announced today that the General Services Administration has awarded ...   This newly formed agreement will allow ... government purchasers, including Department of Veteran Affairs and Department ... contacts purchasing solutions for the Ebola effort in ...
(Date:12/22/2014)... Dec. 22, 2014  ConvaTec, a privately-held medical products ... been appointed Interim Chief Executive Officer of the company, ... Ken Berger .  "The Board of Directors of ... ConvaTec over the past three years," said Magnus ... "We are confident that the company is well positioned ...
Breaking Medicine Technology:TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2
... the lowest dose and the fastest scan speed on ... tomography (CT) scanner is now poised to assist Arnold ... its pediatric patients. The SOMATOM Definition Flash requires only ... required to scan even the tiniest anatomical details. Parents ...
... 28 CMEF Booth #H31/F11 -- Varian Medical Systems, Inc. ... X-ray tubes and flat panel digital X-ray image detectors will ... for digital radiography (DR) at the China International Medical Equipment ... Varian X-Ray will also display its full range of X-ray ...
Cached Medicine Technology:Siemens Delivers Flash Speed, Lowest Dose to Arnold Palmer Hospital for Children 2Siemens Delivers Flash Speed, Lowest Dose to Arnold Palmer Hospital for Children 3Varian Medical Systems to Exhibit a Wide Selection of Flat Panel X-Ray Image Detectors and X-Ray Tubes at the CMEF Show in Chengdu, China 2
... The VacoSplint has a rigid shell with ... an immobilized foot/ankle. The VacoSplint is a non-weight ... weight bear he/she should transfer to the STORM ... remove the nylon liner from the STORM and ...
The Active Ankle Trainer model provides medial/lateral support and optimum ankle mobility for chronic and prophylactic use....
... Walker Pediatric Boot is the ... boot that offers superior comfort ... two sizes are offered thus ... will fit left or right, ...
... features a more open design of our ... Conformer boots. It is used to treat ... patients, plantar fasciitis, bone bruises (stone bruises), ... foot condition that might respond well to ...
Medicine Products: