Navigation Links
Pathway links inflammation, angiogenesis and breast cancer
Date:8/13/2007

IKK and rapamycin injections to inhibit mTOR had mean volumes of less than 100 milimeters. Similar disparate tumor sizes were found when the tumor-suppressing TSC1 was inactivated. Tumors with TSC1 inactivated also were found to have greater blood vessel density - a measure of angiogenesis.

The researchers tested the theory by analyzing breast cancer tumors from 116 patients. They found breast cancer patients whose tumors had the TSC1/TSC2 tumor suppressor complex blocked by phosphorylation did not survive as long as those with an active TSC1/TSC2 (46 percent survival at 60 months vs. 65 percent).

Rapamycin is a powerful immune system suppressor used to protect organ transplant recipients against rejection of their new organs by suppressing mTOR. Rapamycin and similar mTOR inhibitors are in early clinical trials for a number of cancers at M. D. Anderson and elsewhere. One drug, temsirolimus, has been approved to treat renal cell carcinoma.

Hung's lab is exploring the possibility that this TNFa-driven activation of mTOR is the molecular link between obesity and heightened cancer risk. Obese mammals have high levels of TNFa secreted by their fat cells.

For Hung, the Cell paper is part of an ongoing effort to define the cancer-inducing activity of IKK and its sibling, IKKa. He has found that the two, known to have a cancer-inducing affect working together, also have separate effects individually.

In the Cell paper, researchers show IKK does its damage working in the cytosol of the cell, the internal fluid outside of the nucleus. Together, the two kinases previously were known to free the oncoprotein nuclear factor kappa B (NF"B) from the cytosol, allowing it to move to the nucleus and activate genes that promote cancer growth.

IKKa throws switch between tumor promotion and suppression

Earlier this year in a paper published in Molecular Cell, Hung's lab established that IKKa works individually by
'/>"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists Identify Cancer Pathway
2. Expose on eating disorders!! Scientists trace “brain’s eating control center pathway”
3. Citrinin, a fungal toxin, induces apoptosis via mitochondrial pathway
4. Tooth Decay Bacteria Unaffected By Altered Biochemical Pathway
5. Mice model to study bacterial therapeutic pathway
6. Unchecked Cellular Repair Pathway Causes Liver Cancer
7. Lack of Funds in Sudan-Pathway to Epidemic Outbreaks
8. Study Highlights Appetite Regulation Pathway, New Hope for Weight Loss
9. Birth Defects Caused By Deficiencies In Cell Signaling Pathway
10. Discovery of A New Genetic Pathway Could Lead To Treatment Of Skin Problems And Cancer
11. Discovery of Cell Pathway may Help Colon Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... September 16, 2014 Not all recovery ... take care to make sure all their patients are ... some, this may include the newly-introduced online therapy. Millennium ... which gives patients the opportunity to seek treatment from ... provide medical and clinical care at a distance. They ...
(Date:9/16/2014)... WA (PRWEB) September 16, 2014 Duke’s Chowder ... Seattle startups Rebls and Gratafy for a ... and startup hub is firmly cemented. With the growth of companies ... of opportunities for people who work in tech and at startups ... Rebls and Gratafy are happy to host events for their peers ...
(Date:9/16/2014)... A new clinical trial comparing the ... balloons (DEB) in treating in-stent restenosis (ISR) ... superior late angiographic results and better late ... today at the 26th annual Transcatheter Cardiovascular ... Cardiovascular Research Foundation (CRF), TCT is the ...
(Date:9/16/2014)... 16, 2014 Programs and policies that ... of billions of dollars in savings for the US ... Commonwealth Fund. To help spur these types of improvements, ... 10 collaborative groups from across the country to field ... ) - a handbook designed to assist groups working ...
(Date:9/16/2014)... AcousticSheep LLC, makers of the most ... Wireless, their latest version of RunPhones® headphones. RunPhones® Wireless ... active people seeking a safe, comfortable headphone. They ... market and will be available October 1, 2014. ... of the same great features as its predecessor, RunPhones® ...
Breaking Medicine News(10 mins):Health News:Millennium Treatment Group Now Offers Online Therapy 2Health News:Seattle Seafood Restaurant Duke’s Chowder House Partners with Rebls & Gratafy for Tech Networking Happy Hour Event. 2Health News:Seattle Seafood Restaurant Duke’s Chowder House Partners with Rebls & Gratafy for Tech Networking Happy Hour Event. 3Health News:Results of RIBS IV trial reported at TCT 2014 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 3Health News:RunPhones® Prepares to Launch Their New Highly Anticipated Wireless Headphones 2Health News:RunPhones® Prepares to Launch Their New Highly Anticipated Wireless Headphones 3
... The Consumer-Purchaser,Disclosure Project --- a group of leading ... all Americans have access to publicly,reported health care ... General of New York and Cigna Healthcare to ... will,allow physician performance measurement and reporting to proceed ...
... Remind Me Today! reminder program, TORONTO, Oct. 29 ... program - a free telephone-based reminder program designed to,help ... Canada, over 1.3 million women (Stat. Can., 2001) take ... who hasn,t,forgotten to take it at least once. Although ...
... Key Element To An Effective, Hygiene Protocol. ... WASHINGTON, Oct. 29 The recent outbreak ... as an important,reminder of the importance of routine, ... large number of people constantly live,work or play. ...
... may affect heart despite symptom relief, experts say , , ... live longer than they did 40 years ago, but not ... from the Mayo Clinic. , "When you look at persons ... the benefits over the last several decades of improved survival ...
... Patients with chronic tendinosis of the Achilles tendon can ... small amount of a dextrose solution, according to a ... in Vancouver, BC. , Chronic tendinosis is a common ... and can affect many tendons throughout the body, said ...
... announced results from a recent economic analysis of Synagis ... of care for prevention of severe lower respiratory tract ... infants. Released at the American Academy of Pediatrics (AAP) ... costs of providing Synagis to premature infants, as well ...
Cached Medicine News:Health News:Consumers, Health Care Purchasers Applaud Agreement On Physician Performance Reporting 2Health News:Consumers, Health Care Purchasers Applaud Agreement On Physician Performance Reporting 3Health News:Consumers, Health Care Purchasers Applaud Agreement On Physician Performance Reporting 4Health News:Canada leads the way in contraceptive compliance 2Health News:Canada leads the way in contraceptive compliance 3Health News:Spate of Staph Infections Highlight the Need for Thorough, Consistent Cleaning Regimen at Home, at School and at Work 2Health News:Rheumatoid Arthritis Death Rate Unchanged 2Health News:Rheumatoid Arthritis Death Rate Unchanged 3Health News:Ultrasound-guided injections help ease chronic Achilles tendon pain 2
(Date:9/16/2014)... 16, 2014 Research and Markets ... "Global Laparoscopy Devices Industry Report 2014" report ... Laparoscopy Devices Industry Report 2014 is a professional ... the global laparoscopic devices. The report ... definitions, classifications, applications and industry chain structure. The ...
(Date:9/16/2014)... Sept. 16, 2014 Based on its ... Frost & Sullivan recognises Incisive Surgical with the ... Value Leadership. Incisive Surgical,s uniquely-designed, innovative INSORB® Absorbable ... eliminates the need for patients to undergo the ... removal  that may result in increased pain, wound ...
(Date:9/16/2014)... DIEGO , Sept. 16, 2014 Imprimis ... pharmaceutical company dedicated to delivering high quality and novel ... announced that Chief Executive Officer Mark Baum ... Annual Craig-Hallum Alpha Select Conference in New York City.  ... its Go Dropless™ campaign in ophthalmology. The presentation ...
Breaking Medicine Technology:Global Laparoscopy Devices Industry Report 2014 2Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 2Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 3Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 4Frost & Sullivan Commends Incisive Surgical for Delivering Superior Customer Value through its Patient-Centric, Cost-Effective INSORB Absorbable Stapler 5Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 2Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 3Imprimis Pharmaceuticals to Present at Craig-Hallum Alpha Select Conference 4
... Md., Aug. 1, 2011 /PRNewswire-USNewswire/ – CoMeD ... Nations Environment Programme (UNEP) distributed a revised ...  Advocates for mercury-free drugs were gratified to see pharmaceuticals ... the proposed treaty. The Coalition for ...
... 2011 Reportlinker.com announces that a new ... catalogue: Patient Self-Monitoring: Devices, ...   http://www.reportlinker.com/p0581171/Patient-Self-Monitoring-Devices-Markets-Players-and-Prospects .html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic ... monitor their own serum levels is deemed ...
Cached Medicine Technology:Global Mercury Treaty May Include Ban on Mercury in Medicine 2Global Mercury Treaty May Include Ban on Mercury in Medicine 3Patient Self-Monitoring: Devices, Markets, Players and Prospects 2Patient Self-Monitoring: Devices, Markets, Players and Prospects 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: