Navigation Links
'Pathway' Leading to Health Declines of Aging Identified
Date:2/9/2011

WEDNESDAY, Feb. 9 (HealthDay News) -- The "core pathway" that causes declining health due to aging has apparently been identified by researchers.

Studying mice in a laboratory setting, they found that malfunctioning telomeres are the basic cause of age-related health problems such as declining energy levels, metabolic disorders such as diabetes, and the failure of the heart and other organs.

Telomeres are the end-caps of chromosomes that protect against DNA damage. The telomeres become shortened and frayed as cells reach their pre-determined limit on the number of times they can divide. When this happens to telomeres, the ends of the chromosomes become vulnerable to increased rates of unrepaired DNA damage, explained the team at the Dana-Farber Cancer Institute in Boston.

The accumulation of damaged DNA causes cells to activate a gene called p53, which tells cells to either rest until the damage can be repaired or to self-destruct.

The study appears online Feb. 9 in the journal Nature.

"What we have found is the core pathway of aging connecting several age-related biological processes previously viewed as independent of each other," senior author Dr. Ronald A. DePinho said in a Dana-Farber news release.

This research was conducted in mice, but the "findings bear strong relevance to human aging as this core pathway can be directly linked to virtually all known genes involved in aging as well as current targeted therapies designed to mitigate the toll of aging on health," said DePinho, who is director of the Belfer Institute for Applied Cancer Science at Dana-Farber.

More information

The AGS Foundation for Health in Aging offers a guide for healthy aging.

-- Robert Preidt

SOURCE: Dana-Farber Cancer Institute, news release, Feb. 9, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Molecular pathways linked to sex, age affect outcomes in lung cancer
2. Defective signaling pathway sheds light on cystic fibrosis
3. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
4. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
5. Different signaling pathways of cholangiocarcinoma
6. Welsh Tree LLC Proudly Presents the Release of the Celtic Pathways CD by Jason Evans, in Time for Saint Patrick's Day
7. Cellular pathway could provide evidence of how cancer and obesity are linked
8. Newly identified proteins critical to FA pathway DNA repair function
9. Targeting cell pathway may prevent relapse of leukemia
10. Space Coast Cancer Center Selects Via Oncology™ Pathways to Advance Evidence-Based Cancer Care
11. A single protein regulates 2 immune pathways
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Pathway' Leading to Health Declines of Aging Identified 
(Date:5/27/2016)... ... 27, 2016 , ... Beleza Medspa has initiated a new program ... is the first time that Coolsculpting is being used for for more than just ... ensure they meet the prescribed body-fat standard, measured by the circumference-based tape method. ...
(Date:5/27/2016)... ... May 27, 2016 , ... With ... pharmaceutical, medical and food industries. Aside from its GMP accreditation, Validation Center is ... of successfully certified products, services and staff. , Validation Center is ISO17025 accredited ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... thousands of defective respirators, according to court documents and SEC filings. A ... and Becky Tyler v. American Optical Corporation, Case No. BC588866, Los Angeles County, ...
(Date:5/26/2016)... Washington, D.C. (PRWEB) , ... May 26, 2016 , ... ... the men and women who lost their lives in military battle for the country. ... discount cards in 2015 to provide more programs that empower independence for disabled military ...
(Date:5/26/2016)... ... May 26, 2016 , ... MadgeTech will be showcasing its line of ... Warner, New Hampshire at the MadgeTech headquarters. With products sold in more than 100 ... government agencies, including NASA. , In 2012, NASA strategically set up 17 RHTemp101A ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... -- According to a new market research ... by Therapeutic Area (Oncology, Cosmeceutical/Plastic Surgery), by Application (Drug ... Hospitals/ Clinics) - Forecast to 2021", published by MarketsandMarkets, ... the forecast period of 2016 to 2021. This market ... from USD 117.3 Million in 2016, at a CAGR ...
(Date:5/25/2016)... Germany and GERMANTOWN, Maryland ... N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) ... and co-development agreement with Therawis Diagnostics GmbH to develop and ... to develop and market PITX2 as a marker to predict ... breast cancer patients. "We are pleased to partner ...
(Date:5/25/2016)... , May 25, 2016  According to Kalorama ... $381 billion in 2015.  Though these are challenging ... of opportunity for success for companies that remain ... search of new growth prospects medical device companies ... research and development (R&D) than do companies in ...
Breaking Medicine Technology: