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Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes
Date:2/9/2009

Scientists at the German Cancer Research Center have discovered a mechanism in liver metabolism that is responsible for pathologically elevated blood fat levels found in severe metabolic disorders. Mice suffering from metabolic syndrome or type 2 diabetes produce only small amounts of a molecule called LSR in the liver, as reported by researchers headed by Dr. Stephan Herzig in the journal "Diabetes". As a result, only small amounts of fat are transported from the blood into the liver and blood fat levels rise immensely.

People who are severely overweight frequently suffer from a condition called metabolic syndrome. It is associated with pathologically elevated blood pressure, blood lipid (triglycerides) and blood sugar levels. Metabolic syndrome can develop into type 2 diabetes and lead to narrowing of the blood vessels (arteriosclerosis), which, in turn, increases the risk of myocardial infarction. For many years, it was unclear what causes the elevated blood fat levels in this condition.

Dr. Stephan Herzig, head of the Research Group "Molecular Metabolic Control" at the German Cancer Research Center, and his team have now shown that lipid transporter LSR (lipolysis-stimulated lipoprotein receptor) appears to be responsible for this. LSR, a molecule found in the bowel and primarily in the liver, is responsible for the uptake of fat from the blood. In overweight mice suffering from type 2 diabetes, the production of LSR in the liver is significantly reduced, as Herzig and his colleagues found out. As a result, only little fat makes its way from the blood into the liver and this makes blood fat levels go up.

By administering leptin, a proteohormone which suppresses hunger, the scientists were able to restore the reduced LSR production in the liver of diabetic mice to normal levels. The overweight mice treated with leptin lost weight dramatically up to 30 percent of their body weight. At the same time, their livers produced
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Contact: Dr. Stefanie Seltmann
presse@dkfz.de
49-622-142-2854
Helmholtz Association of German Research Centres
Source:Eurekalert

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