Navigation Links
Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes
Date:2/9/2009

Scientists at the German Cancer Research Center have discovered a mechanism in liver metabolism that is responsible for pathologically elevated blood fat levels found in severe metabolic disorders. Mice suffering from metabolic syndrome or type 2 diabetes produce only small amounts of a molecule called LSR in the liver, as reported by researchers headed by Dr. Stephan Herzig in the journal "Diabetes". As a result, only small amounts of fat are transported from the blood into the liver and blood fat levels rise immensely.

People who are severely overweight frequently suffer from a condition called metabolic syndrome. It is associated with pathologically elevated blood pressure, blood lipid (triglycerides) and blood sugar levels. Metabolic syndrome can develop into type 2 diabetes and lead to narrowing of the blood vessels (arteriosclerosis), which, in turn, increases the risk of myocardial infarction. For many years, it was unclear what causes the elevated blood fat levels in this condition.

Dr. Stephan Herzig, head of the Research Group "Molecular Metabolic Control" at the German Cancer Research Center, and his team have now shown that lipid transporter LSR (lipolysis-stimulated lipoprotein receptor) appears to be responsible for this. LSR, a molecule found in the bowel and primarily in the liver, is responsible for the uptake of fat from the blood. In overweight mice suffering from type 2 diabetes, the production of LSR in the liver is significantly reduced, as Herzig and his colleagues found out. As a result, only little fat makes its way from the blood into the liver and this makes blood fat levels go up.

By administering leptin, a proteohormone which suppresses hunger, the scientists were able to restore the reduced LSR production in the liver of diabetic mice to normal levels. The overweight mice treated with leptin lost weight dramatically up to 30 percent of their body weight. At the same time, their livers produced
'/>"/>

Contact: Dr. Stefanie Seltmann
presse@dkfz.de
49-622-142-2854
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study links obesity to elevated risk of ovarian cancer
2. Hispanic Men Face Elevated Risk of Erectile Dysfunction
3. Statin Reduces Heart Attack, Stroke Rates in Patients With Normal Cholesterol but Elevated C-Reactive Protein
4. Elevated biomarkers predict risk for prostate cancer recurrence
5. Pittsburgh scientists find protein may be key to new therapies for elevated triglycerides
6. Heart Hormone Elevated in Children Who Wet Bed
7. Elevated Urate Levels May Slow Parkinsons in Men
8. Envisat makes first ever observation of regionally elevated CO2 from manmade emissions
9. Elevated liver enzymes associated with higher future mortality
10. CRESTOR(R) Now Indicated to Slow the Progression of Atherosclerosis in Patients With Elevated Cholesterol
11. Store-bought freshwater fish contain elevated levels of mercury, arsenic and selenium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... ... the global cancer enterprise of Hospital Corporation of America (HCA), as it further ... research, OncLive announced today. , With this new partnership, OncLive’s editorial and ...
(Date:7/1/2015)... ... 2015 , ... Lisa Keys, the widow of U.S. Army Master Sergeant Bradley ... in memory of her late husband and all of America’s fallen military and first ... Medal, died during a Special Forces training exercise in December of 2012. The ‘Legacy ...
(Date:7/1/2015)... Louisville, KY (PRWEB) , ... July 01, 2015 ... ... Health Care Transformation Task Force, contributing to newly released white paper: “Pro-actively Identifying ... The paper was published July 1st and is available at: http://www.hcttf.org/resouces-tools . ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... ... mesothelioma compensation law has just published a top ten list they hope will ... report. Click here to read it now. , More than ...
(Date:7/1/2015)... ... 2015 , ... B. E. Smith, the only full-service leadership ... national chief executive officer recruitment for Citizens Medical Center in Victoria, ... E. Smith has recently placed more than 1,000 healthcare executives into organizations. ...
Breaking Medicine News(10 mins):Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 2Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 3Health News:Wife of Fallen Special Forces Soldier to Host Nationwide ‘Virtual 5K’ for Charity 2Health News:Wife of Fallen Special Forces Soldier to Host Nationwide ‘Virtual 5K’ for Charity 3Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 2Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 3Health News:New Report Identifies Top 10 Mesothelioma Research Priorities, According to Surviving Mesothelioma 2Health News:Citizens Medical Center Retains B. E. Smith to Recruit New CEO 2Health News:Citizens Medical Center Retains B. E. Smith to Recruit New CEO 3
... They Have Approved LISTEX(TM) P100, the Natural Bacteriophage Product ... all Food Products . ,In the fight against ... food processing companies can now apply a novel yet ... approved this product from The Netherlands as GRAS, based ...
... that glaciers are receding and lakes are drying up in ... ,Even while some sections are adamantly skeptical about such assertions, ... whole lake in the south of the country. ... Bernardo O'Higgins National Park in Patagonia, Chile, was last seen ...
... father is preparing himself to electrify the entire world with a ... ,He is hoping to arouse the conscience of ... handed him a huge embarrassment by being hauled up on drug ... Former US Vice President Al Gores son Albert Arnold Gore III ...
... cells of the immune system can circulate throughout the ... trained. ,Led by McMaster University's ... the ongoing immune system research through a new Cancer ... funding from the Terry Fox Foundation through the National ...
... 1st issue of G&D, Dr. Douglas Black (UCLA) and ... development. ,Alternative splicing refers to the ... by including some exons and excluding others. Specific cell ... ,Polypyrimidine-tract binding protein (PTB) is a well-known inhibitor ...
... a law student, Zhao Mengyuan has a peculiar way of ... in distress . ,It all takes place in ... busy to do it themselves has become a handy source ... job for thousands of other Chinese. ,Zhao, a ...
Cached Medicine News:Health News:FDA Extends GRAS Approval Listex to All Food Products 2Health News:Chilean Lake Disappears, Thanks to Global Warming 2Health News:Former US Vice President Al Gores Son Continues to Be Dogged by Drug Abuse Problem. 2Health News:Harnessing Immune System Power Heralds Next Era of Cancer Treatment 2Health News:In China, Online Gamers Raking in the Cash 2Health News:In China, Online Gamers Raking in the Cash 3
(Date:7/1/2015)...  Celsion Corporation (NASDAQ: CLSN ), an oncology ... Tardugno , Chairman, President and CEO, is scheduled to ... Wednesday, July 8, 2015, at 4:15 p.m. Eastern Time. The ... located at 119 W. 56th Street, New ... of the presentation will be available in the Events ...
(Date:7/1/2015)... 2015 Radiant Insights announce that ... Concentrators Market Shares, Strategy, and Forecasts, Worldwide, 2015 ... growth as the aging population worldwide needs homecare oxygen ... where oxygen is able to improve the quality of ... become affordable and support a mobile lifestyle even while ...
(Date:7/1/2015)... July 1, 2015 New exchange plan enrollees ... 2015 compared to the same time a year ago, ... (NASDAQ: ESRX ) Exchange Pulse™ report, released today. ... 2014, the number of new exchange plan enrollees who ... in the first quarter of 2015. However, when evaluating ...
Breaking Medicine Technology:Celsion Corporation to Present at Cantor Fitzgerald's Inaugural Healthcare Conference on July 8, 2015 2Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 2Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 3Stationary Oxygen Concentrators Market to Reach $2 Billion by 2021: Radiant Insights, Inc. 4Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 2Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 3Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 4Express Scripts Provides First Look at 2015 Public Exchange Pharmacy Trends 5
... 30 London Genetics Limited, an expert in,the ... development, has,entered an intensive partnering programme following on ... recognised that while,pharmacogenetics and genetics have great potential ... early clinical,collaboration between companies, academia, regulators and payers ...
... FRANCISCO, Oct. 30 CCBR-SYNARC, the world,s leading provider ... center services to the pharmaceutical and biotechnology industries, announced ... for use in imaging clinical trials. , SYNARC has ... 2004. With the release of the enhanced SynarcConnect(SM) ...
Cached Medicine Technology:London Genetics Focuses on Partnering Following Successful Pharmacogenetics Conference 2London Genetics Focuses on Partnering Following Successful Pharmacogenetics Conference 3London Genetics Focuses on Partnering Following Successful Pharmacogenetics Conference 4CCBR-SYNARC Expands Electronic Data Capture Capabilities 2
Fixed smooth rod which slides on skin. Designated most popular model or size....
... blade. 17 mm wide blade. ... inches. Note: Has Marcks attachment ... to any thickness up to ... thicker grafts or split graft. ...
6 mm x 23 mm blunt, double-edged blade. Flat handle....
Double-ended. Blades set at 45 and 90 degrees. Hexagonal handle....
Medicine Products: