Navigation Links
Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes
Date:2/9/2009

Scientists at the German Cancer Research Center have discovered a mechanism in liver metabolism that is responsible for pathologically elevated blood fat levels found in severe metabolic disorders. Mice suffering from metabolic syndrome or type 2 diabetes produce only small amounts of a molecule called LSR in the liver, as reported by researchers headed by Dr. Stephan Herzig in the journal "Diabetes". As a result, only small amounts of fat are transported from the blood into the liver and blood fat levels rise immensely.

People who are severely overweight frequently suffer from a condition called metabolic syndrome. It is associated with pathologically elevated blood pressure, blood lipid (triglycerides) and blood sugar levels. Metabolic syndrome can develop into type 2 diabetes and lead to narrowing of the blood vessels (arteriosclerosis), which, in turn, increases the risk of myocardial infarction. For many years, it was unclear what causes the elevated blood fat levels in this condition.

Dr. Stephan Herzig, head of the Research Group "Molecular Metabolic Control" at the German Cancer Research Center, and his team have now shown that lipid transporter LSR (lipolysis-stimulated lipoprotein receptor) appears to be responsible for this. LSR, a molecule found in the bowel and primarily in the liver, is responsible for the uptake of fat from the blood. In overweight mice suffering from type 2 diabetes, the production of LSR in the liver is significantly reduced, as Herzig and his colleagues found out. As a result, only little fat makes its way from the blood into the liver and this makes blood fat levels go up.

By administering leptin, a proteohormone which suppresses hunger, the scientists were able to restore the reduced LSR production in the liver of diabetic mice to normal levels. The overweight mice treated with leptin lost weight dramatically up to 30 percent of their body weight. At the same time, their livers produced substantially more LSR, and blood fat levels dropped back to normal.

"Thus, we have shown for the first time that the LSR molecule plays a central role in lipid metabolism," Herzig says. We were also able to provide evidence that apparently it depends on body weight how much LSR is produced in the liver: being overweight is associated with reduced production." Hence LSR is a possible target for future treatments of metabolic syndrome and type 2 diabetes. There is a great need for such treatments, since it is estimated that about 300 million people worldwide will suffer from type 2 diabetes as early as next year. "If we were able to increase hepatic LSR production in these patients, this would relieve essential aspects of this disease," said Herzig. All the more so because increased LSR production in the liver not only reduces blood fat levels but also promotes fat breakdown in the liver.

Cancer patients, too, might benefit from these findings. Many of them suffer from what is called tumor cachexia a life-threatening loss of weight that is associated with the development of fatty liver. "We have found first evidence suggesting that LSR is overproduced in the livers of these patients so that too much fat accumulates in the liver, while peripheral organs are hardly supplied with fat, or energy," Herzig says. However, he adds, more research needs to be done.


'/>"/>

Contact: Dr. Stefanie Seltmann
presse@dkfz.de
49-622-142-2854
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Study links obesity to elevated risk of ovarian cancer
2. Hispanic Men Face Elevated Risk of Erectile Dysfunction
3. Statin Reduces Heart Attack, Stroke Rates in Patients With Normal Cholesterol but Elevated C-Reactive Protein
4. Elevated biomarkers predict risk for prostate cancer recurrence
5. Pittsburgh scientists find protein may be key to new therapies for elevated triglycerides
6. Heart Hormone Elevated in Children Who Wet Bed
7. Elevated Urate Levels May Slow Parkinsons in Men
8. Envisat makes first ever observation of regionally elevated CO2 from manmade emissions
9. Elevated liver enzymes associated with higher future mortality
10. CRESTOR(R) Now Indicated to Slow the Progression of Atherosclerosis in Patients With Elevated Cholesterol
11. Store-bought freshwater fish contain elevated levels of mercury, arsenic and selenium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... , ... "I had a terrible time trying to get my grandson to ... the nebulizer had a more child-friendly design, then children would be more likely to ... NEBY to avoid the need to deliver medication via a nebulizer mask. The design ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... distinction by the Undersea and Hyperbaric Medical Society (UHMS), the leading authority in ... and patient safety. Only a few hospitals and facilities have earned this distinction. ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... announce that “Natural Language Processing–Enabled and Conventional Data Capture Methods for Input to ... Medical Informatics . , Results of the comparative usability study demonstrate that a ...
(Date:12/8/2016)... ... December 08, 2016 , ... CURE Media Group, the nation’s leading digital ... aligned with Upstage Lung Cancer in efforts to combat lung cancer, announced CURE Media ... Jr said, “CURE Media Group is honored to team up with Upstage Lung Cancer ...
(Date:12/8/2016)... ... ... Premier Fitness Camp (PFC) and The Chopra Center for Wellbeing announced today the ... their world headquarters of Omni La Costa Resort & Spa in San Diego. , ... loss, personal development, a healthy lifestyle, or mental and physical healing. The week-long wellness ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec 8, 2016 Research and Markets has announced ... report to their offering. ... This report analyzes the worldwide markets for Endodontic Supplies ... Canada , Japan , Europe ... Rest of World. Annual estimates and forecasts are provided for the ...
(Date:12/8/2016)... Dec. 8, 2016   TriNetX , the ... Children,s Hospital signed a membership agreement to ... development of new cures. The TriNetX ... 57 million patients globally, biopharmaceutical companies and contract ... improve protocol design, site selection, patient recruitment, and ...
(Date:12/8/2016)... 8, 2016  Valeant Pharmaceuticals International, Inc. (NYSE: ... today announced positive results from a Phase 3, ... the safety and efficacy of IDP-118 (halobetasol propionate ... psoriasis. Within the Phase 3 ... severe psoriasis, IDP-118 showed statistical significance to vehicle ...
Breaking Medicine Technology: