Navigation Links
Patent pending for pain-free method of monitoring drug levels in transplant patients
Date:4/3/2009

KINGSTON, R.I. March 27, 2009 The U.S. Patent and Trademark Office is reviewing a University of Rhode Island pharmacy professor's proposal to use saliva as a non-invasive way to monitor concentrations of anti-rejection drugs in patients that undergo transplants.

Associate Professor of Pharmacy Fatemeh Akhlaghi said saliva offers a pain-free way to measure levels of immunosuppressive agents such as cyclosporine, and mycophenolic acid, which are essential in preventing organ rejection after transplantation. She is also researching the use of saliva for monitoring the concentration of two other immunosuppressive drugs, tacrolimus and sirolimus.

"Routine concentration measurement for these agents is essential for their efficacious and safe use. This is currently done through blood tests that are usually administered twice a week in a clinic or hospital," Akhlaghi said. "Our method uses saliva to measure these drug levels. Saliva tests are good for children and elderly. With the elderly, blood draws can be difficult because of the loss of muscle and connective tissue, making the veins less stable and more prone to bruising."

Frequent testing of medication levels in transplant patients is required for two reasons; if the concentration of an immunosuppressive agent is low, the patient risks rejection of the organ, and if the concentrations are high, the patient risks infections and toxicity.

"We seek commercial partners to allow us to expand the clinical studies, optimize the sample collection procedure and investigate the possibility of developing non-mass spectrometry methods for this application," Akhlaghi said.

Mass spectrometry is an instrumental method for identifying the chemistry of a substance through the separation of gaseous ions based on their differing mass and charge. Akhlaghi's method is less complicated and less expensive.

"This method is very effective for the drugs listed in my study," Akhlaghi said. "And it's not just because the method is less invasive. We actually came up with more precise measures of the drugs' effects.

"Saliva allows non-invasive specimen collection by the patient at home," she added. "Patients can just put the sample in the mail."

Obtaining a sample would be as simple as spitting in a cup or taking a swab of the mouth, Akhlaghi said. "Because a transplant patient remains dependent on life-long therapy with a cocktail of immunosuppressive agents, a non-invasive monitoring procedure is important. It's all about improving the patient's quality of life."


'/>"/>

Contact: David Lavallee
dlavallee@advance.uri.edu
401-874-2116
University of Rhode Island
Source:Eurekalert

Related medicine news :

1. Patent Reform Legislation Threatens Americas Leadership in Medical Technology Innovation
2. Spectranetics to Appeal Decision in Patent Litigation
3. Patent Expiries of Proscar and Flomax/Harnal Will Cause a Significant Decline in Near-Term Sales of Benign Prostatic Hyperplasia Drugs
4. Actavis Confirms its Patent Challenge of Kings Avinza(R)
5. PartsSource Awarded US Patent for PartsFinder(TM) Application
6. Barr Confirms Patent Challenge of UROXATRAL(R)
7. Former Pfizer Patent Attorneys Join Brinks Hofer Gilson & Lione
8. VNUS Medicals Patent Lawsuit Against Laser Competitors to Proceed to Trial
9. Aida Granted Additional Anti-Cancer Patent
10. China Medicines ADTZ Project Has Been Selected as One of Six Patent Commercialization Projects in Guangdong Province
11. Wiley X Eyewear(R) Announces Successful Resolution of Patent Infringement Litigation Against PanOptx(R), Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2017)... ... , ... Ecommerce sales have grown every year since the 1990’s, with 2016 ... consequences of rapid innovation and growth are often neglected in the name of progress. ... and individual’s job to give something back to the planet that provides the resources ...
(Date:4/22/2017)... Capistrano (PRWEB) , ... April 22, 2017 , ... The San Juan Capistrano summer ... released a parenting report outlining the need for summer camps to provide physical activities for ... Importance of Physical Activity In Summer Camps , With an increase in specialty camps that ...
(Date:4/21/2017)... MA (PRWEB) , ... April 21, 2017 , ... ... University professor Christopher Salas-Wright finds that youth violence is declining—and at noteworthy rates. ... the relative proportion of young people involved in violence in the United States. ...
(Date:4/21/2017)... ... April 21, 2017 , ... Young Asset Protection, an insurance ... throughout the greater Pittsburgh metropolitan region, is joining forces with the local chapter ... differently-abled children. , Variety the Children’s Charity is a national organization dedicated to ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... ... announced it’s been named Agency of Record (AOR) for Theravent, Inc. , ... eliminate snoring. Theravent’s parent company, Foundation Consumer Healthcare, is now working to expand ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... DUBLIN, Ohio , April 18, 2017  Cardinal ... its Non-GAAP 1 fiscal 2017 earnings per share ... 2018 and 2019.  This is in conjunction with this ... Care, Deep Vein Thrombosis and Nutritional Insufficiency businesses. ... EPS from continuing operations will be at the bottom ...
(Date:4/18/2017)... DIEGO , April 18, 2017  Astute Medical, ... a case series to be presented at the 2017 ... which begins today and continues through April 22. Physicians ... IGFBP-7 , used to assess risk for acute kidney ... decompensated heart failure (ADHF). Elevated levels ...
(Date:4/18/2017)... -- Spero Therapeutics, LLC, a biopharmaceutical company founded to develop ... present preclinical data supporting the use of SPR741 combination ... infections at the 27th European Congress of Clinical Microbiology ... Vienna, Austria . ... "Our ongoing preclinical research helps ...
Breaking Medicine Technology: