Navigation Links
Patent pending for pain-free method of monitoring drug levels in transplant patients
Date:4/3/2009

KINGSTON, R.I. March 27, 2009 The U.S. Patent and Trademark Office is reviewing a University of Rhode Island pharmacy professor's proposal to use saliva as a non-invasive way to monitor concentrations of anti-rejection drugs in patients that undergo transplants.

Associate Professor of Pharmacy Fatemeh Akhlaghi said saliva offers a pain-free way to measure levels of immunosuppressive agents such as cyclosporine, and mycophenolic acid, which are essential in preventing organ rejection after transplantation. She is also researching the use of saliva for monitoring the concentration of two other immunosuppressive drugs, tacrolimus and sirolimus.

"Routine concentration measurement for these agents is essential for their efficacious and safe use. This is currently done through blood tests that are usually administered twice a week in a clinic or hospital," Akhlaghi said. "Our method uses saliva to measure these drug levels. Saliva tests are good for children and elderly. With the elderly, blood draws can be difficult because of the loss of muscle and connective tissue, making the veins less stable and more prone to bruising."

Frequent testing of medication levels in transplant patients is required for two reasons; if the concentration of an immunosuppressive agent is low, the patient risks rejection of the organ, and if the concentrations are high, the patient risks infections and toxicity.

"We seek commercial partners to allow us to expand the clinical studies, optimize the sample collection procedure and investigate the possibility of developing non-mass spectrometry methods for this application," Akhlaghi said.

Mass spectrometry is an instrumental method for identifying the chemistry of a substance through the separation of gaseous ions based on their differing mass and charge. Akhlaghi's method is less complicated and less expensive.

"This method is very effective for the drugs listed in my study," Akhlaghi
'/>"/>

Contact: David Lavallee
dlavallee@advance.uri.edu
401-874-2116
University of Rhode Island
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Patent Reform Legislation Threatens Americas Leadership in Medical Technology Innovation
2. Spectranetics to Appeal Decision in Patent Litigation
3. Patent Expiries of Proscar and Flomax/Harnal Will Cause a Significant Decline in Near-Term Sales of Benign Prostatic Hyperplasia Drugs
4. Actavis Confirms its Patent Challenge of Kings Avinza(R)
5. PartsSource Awarded US Patent for PartsFinder(TM) Application
6. Barr Confirms Patent Challenge of UROXATRAL(R)
7. Former Pfizer Patent Attorneys Join Brinks Hofer Gilson & Lione
8. VNUS Medicals Patent Lawsuit Against Laser Competitors to Proceed to Trial
9. Aida Granted Additional Anti-Cancer Patent
10. China Medicines ADTZ Project Has Been Selected as One of Six Patent Commercialization Projects in Guangdong Province
11. Wiley X Eyewear(R) Announces Successful Resolution of Patent Infringement Litigation Against PanOptx(R), Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... May 22, 2015 Mountain Point Medical Center, ... ribbon cutting ceremony on Friday, May 29, 2015 at 11 ... 6 p.m. The new medical center, set to officially open ... Boulevard, Lehi, UT 84043. , “The opening of Mountain ... and the Utah County community,” said Kent Loosle, CEO of ...
(Date:5/22/2015)... May 22, 2015 Omar Ahmad Barrada, ... to participate in the 2015 Congress of Future Medical ... as a gathering of “America’s highest achieving high school ... of healthcare, set new goals and learn better study ... live surgery, during which we can ask the surgeons ...
(Date:5/22/2015)... 22, 2015 Family, friends, students, colleagues, ... surgical oncologist, Dr. LaSalle D. Leffall, on Monday, May ... began after Grand Rounds in the hospital’s Tower Auditorium. ... outside the auditorium, trying to keep the secret. “I’d ... he sees me, he’ll know something is up,” she ...
(Date:5/22/2015)... 22, 2015 According to a new Aegis ... are equally as likely to worry about what will happen ... X, 77% Boomers, 69% Silent Generation), which may help explain ... scared of aging, particularly Millennials (47%), Gen X’ers (51%), and ... in April, 2015 among more than 2,000 U.S. adults ages ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 According to ... hub for drug related death, totaling almost 2,500 confirmed drug ... reported by state officials, totals 2,489 deaths stemming from legal ... out, Pennsylvania loses seven people every day to fatal overdoses ... been singled out as one of the most rife with ...
Breaking Medicine News(10 mins):Health News:Mountain Point Medical Center, a Campus of Jordan Valley Medical Center, Hosts Ribbon Cutting Ceremony and Community Celebration on Friday, May 29, 2015 2Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2Health News:Colleagues Surprise Dr. LaSalle Leffall with 85th Birthday Celebration 2Health News:New Study Reveals America’s Fear of Aging 2Health News:New Study Reveals America’s Fear of Aging 3Health News:Philadelphia Ranks Among the Tops Cities in Penn. for Drug Deaths 2
... at the Salk Institute for Biological Studies, fisetin, a ... fruits and vegetables, invigorates signaling pathways that boost long-term ... week’s Online Early Edition of the Proceedings of the ... in over 30% of the people aged 60 and ...
... in US have come up with a heady option that ... in brain cells often after an episode of stroke or ... John Hopkins University ,who conducted a study on mice, ... the skin of red grapes, administered in moderate doses, showed ...
... three sisters Julie Owen, Pam Dugmore and Rosemary Moss at ... which determined// whether they were carriers of a mutated gene ... of developing breast cancer. ,The results revealed that ... gene. Only Rosemary, 64, did not. The sisters were advised ...
... who are gluten intolerant run four times the risk of ... print in Thorax. // ,Gluten intolerance, or ... bowel, caused by an exaggerated immune response to the gluten ... up to 1% of the population, and has been linked ...
... supplements for good health despite the fact that few actually ... the best way to stay healthy is a balanced diet. ... worried that food has fewer nutrients than it used to, ... is freshly picked produce, reported the online edition of Daily ...
... the fatal lung disease; Chronic Obstructive Pulmonary Disease (COPD) ... smokers//. ,Chronic bronchitis and emphysema constitute COPD, ... globe. Cough, fatigue, shortness of breath and subsequent difficulty ... ,The scientists at the Hvidovre Hospital in Denmark conducted ...
Cached Medicine News:Health News:Eating Strawberries may boost memory 2Health News:Eating Strawberries may boost memory 3Health News:A Family's Fight against Breast cancer 2Health News:A Family's Fight against Breast cancer 3Health News:Madhya Pradesh Tops in Implementing Child Health Scheme 2
(Date:5/22/2015)... KING OF PRUSSIA, Pa. , May 22, 2015 ... CSL Behring its 2015 Corporate Leadership Award as ... science and improving the care of the bleeding disorders community.  ... and Managing Director, CSL Limited, during the NHF Annual Spring ... May 21. "The National Hemophilia Foundation is dedicated ...
(Date:5/22/2015)... InspireMD, Inc. (NYSE MKT: NSPR) ("InspireMD" or the "Company"), ... that its CGuard TM Embolic Prevention System reported positive ... Musialek , at the EuroPCR conference on May ... PARADIGM, an investigator-initiated P rospective evaluation of ... revascularization I n symptomatic and increased-risk asymptomatic carotid artery ...
(Date:5/22/2015)... 2015 AcelRx Pharmaceuticals, Inc. (Nasdaq: ACRX ... and commercialization of innovative therapies for the treatment of ... executive officer Howie Rosen will be presenting ... Tim Morris will be presenting at JMP ... are as follows: Jefferies 2015 Healthcare Conference ...
Breaking Medicine Technology:National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4AcelRx Pharmaceuticals to Present at Two Upcoming Investor Conferences In June 2
... Medical Affiliates, Inc. (Pink Sheets: UCIA ) today announced ... the quarter ended June 30, 2010. Revenues for the ... or 9.23% over revenues of $19,264,467 for the quarter ended June ... the quarter ended June 30, 2010 compared to net income of ...
... is pleased to announce that Robert R. Bulger, M.D. ... of minimally invasive back pain treatment techniques.  The ... a variety of conditions responsible for back pain on ... American Spine,s trained physicians are the only doctors performing ...
Cached Medicine Technology:UCI Medical Affiliates, Inc. Reports Third Quarter Results for Fiscal Year 2010 2UCI Medical Affiliates, Inc. Reports Third Quarter Results for Fiscal Year 2010 3UCI Medical Affiliates, Inc. Reports Third Quarter Results for Fiscal Year 2010 4North American Spine Welcomes Robert R. Bulger, M.D. to Dallas Physician Group 2North American Spine Welcomes Robert R. Bulger, M.D. to Dallas Physician Group 3
Inquire...
Inquire...
For use with Snap-In Snap-Out-II tip inserts. Available in five styles, the Snap-In Snap-Out-II Laparoscopic Instrument Handles offer the broadest range available....
Inquire...
Medicine Products: