Navigation Links
Patent pending for pain-free method of monitoring drug levels in transplant patients
Date:4/3/2009

KINGSTON, R.I. March 27, 2009 The U.S. Patent and Trademark Office is reviewing a University of Rhode Island pharmacy professor's proposal to use saliva as a non-invasive way to monitor concentrations of anti-rejection drugs in patients that undergo transplants.

Associate Professor of Pharmacy Fatemeh Akhlaghi said saliva offers a pain-free way to measure levels of immunosuppressive agents such as cyclosporine, and mycophenolic acid, which are essential in preventing organ rejection after transplantation. She is also researching the use of saliva for monitoring the concentration of two other immunosuppressive drugs, tacrolimus and sirolimus.

"Routine concentration measurement for these agents is essential for their efficacious and safe use. This is currently done through blood tests that are usually administered twice a week in a clinic or hospital," Akhlaghi said. "Our method uses saliva to measure these drug levels. Saliva tests are good for children and elderly. With the elderly, blood draws can be difficult because of the loss of muscle and connective tissue, making the veins less stable and more prone to bruising."

Frequent testing of medication levels in transplant patients is required for two reasons; if the concentration of an immunosuppressive agent is low, the patient risks rejection of the organ, and if the concentrations are high, the patient risks infections and toxicity.

"We seek commercial partners to allow us to expand the clinical studies, optimize the sample collection procedure and investigate the possibility of developing non-mass spectrometry methods for this application," Akhlaghi said.

Mass spectrometry is an instrumental method for identifying the chemistry of a substance through the separation of gaseous ions based on their differing mass and charge. Akhlaghi's method is less complicated and less expensive.

"This method is very effective for the drugs listed in my study," Akhlaghi said. "And it's not just because the method is less invasive. We actually came up with more precise measures of the drugs' effects.

"Saliva allows non-invasive specimen collection by the patient at home," she added. "Patients can just put the sample in the mail."

Obtaining a sample would be as simple as spitting in a cup or taking a swab of the mouth, Akhlaghi said. "Because a transplant patient remains dependent on life-long therapy with a cocktail of immunosuppressive agents, a non-invasive monitoring procedure is important. It's all about improving the patient's quality of life."


'/>"/>

Contact: David Lavallee
dlavallee@advance.uri.edu
401-874-2116
University of Rhode Island
Source:Eurekalert

Related medicine news :

1. Patent Reform Legislation Threatens Americas Leadership in Medical Technology Innovation
2. Spectranetics to Appeal Decision in Patent Litigation
3. Patent Expiries of Proscar and Flomax/Harnal Will Cause a Significant Decline in Near-Term Sales of Benign Prostatic Hyperplasia Drugs
4. Actavis Confirms its Patent Challenge of Kings Avinza(R)
5. PartsSource Awarded US Patent for PartsFinder(TM) Application
6. Barr Confirms Patent Challenge of UROXATRAL(R)
7. Former Pfizer Patent Attorneys Join Brinks Hofer Gilson & Lione
8. VNUS Medicals Patent Lawsuit Against Laser Competitors to Proceed to Trial
9. Aida Granted Additional Anti-Cancer Patent
10. China Medicines ADTZ Project Has Been Selected as One of Six Patent Commercialization Projects in Guangdong Province
11. Wiley X Eyewear(R) Announces Successful Resolution of Patent Infringement Litigation Against PanOptx(R), Inc.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... According to a new study ... because it does not obey the rules Congress has directed the CBO to follow. ... the GOP reform would restore. Yet, it estimates a reduction in employer-based coverage due ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... planning, and related services to families and business owners across eastern Michigan, is ... feeding regional families struggling with financial difficulties. , The Oxford/Orion FISH Food Pantry ...
(Date:3/24/2017)... ... 24, 2017 , ... As the standards bearer of advanced ... that positions them as the go-to thought leader in all matters concerning oncology ... an always-on, always-fresh news, views and advocacy engine, called ONS Voice. , The ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... The law ... White Plains, N.Y., is pleased to announce Westchester resident Lauren C. Enea has joined ... clerk for the firm, will concentrate her practice in elder law, Medicaid planning and ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... year of enhancements, upgrading their training and leads programs. , In February, 2017, ... for elite sales agents, Performance Partners is designed to teach how to maximize ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , March 23, 2017  Mirabilis Medical, ... advanced medical technology for non-invasive surgery, announced today ... System for treatment of uterine fibroids throughout the ... had received approval from the US Food and ... the Mirabilis System in the United States.  The ...
(Date:3/24/2017)... , Mar 24, 2017 The Board ... the company,s Annual Report 2016 including the complete 2016 Annual ... and available on Nordic Nanovector,s website in the section Investor ... ... IR enquiries: Tone Kv√•le, Chief Financial Officer Cell: +47-91-51-95-76 Email: ...
(Date:3/23/2017)... PUNE, India , March 23, 2017 ... are growing ageing population, increasing diabetic population, accelerating economic growth ... developments of this industry are higher life expectancy of ESRD ... potential in emerging markets. However, the expansion of the market ... ...
Breaking Medicine Technology: