Navigation Links
Patch Helps Mend Damaged Hearts
Date:7/30/2008

Study finds it promotes growth of healthy tissue after heart attack

WEDNESDAY, July 30 (HealthDay News) -- A mesh patch designed to regenerate cardiac muscle damaged by a heart attack or heart failure has done well in animal studies and preliminary human trials.

The patch is made of vicryl, a material used for suturing injured tissue that is later absorbed by the body, explained Jordan J. Lancaster, a predoctoral fellow at the Southern Arizona VA Medical Center in Tucson, who reported on the animal studies Wednesday at an American Heart Association meeting in Keystone, Colo.

"The mesh is grown in a bioreactor with human dermal fibroblast cells," Lancaster said. When the patch is placed on the heart, it delivers cells that grow to strengthen the heart muscle.

"We evaluated this patch in two studies," Lancaster said. "One was in an acute situation, immediately after a heart attack, the other was in chronic heart failure."

After a heart attack, he explained, there is abnormal enlargement of the left ventricle, which pumps blood to the body. The ventricle also works harder, which can ultimately lead to heart failure.

Applying the patch to rats after a heart attack, "we were able to prevent the negative functioning and the negative remodeling," Lancaster said. Blood flow to the heart muscle increased by 37 percent for rats who got the patch immediately after a heart attack, and the blood-pumping ability of the heart increased by 40 percent.

A second series of experiments applied the patch to rats three weeks after a heart attack to study its effect on heart failure. Blood flow was improved by 116 percent, and blood-pumping ability improved by 21 percent.

The animal studies were sponsored by Theregen Inc., a San Francisco company that has started human studies of the patch. A first study, primarily to test the safety of the patch, was done last year by Dr. Bartley P. Griffith, chief of cardiac surgery at the University of Maryland.

"We were very pleased," Griffith said of the trial, which included 12 heart attack patients. "In our patients, the application of the patch was not associated with any complications. The application of the patch is quite simple. Four stitches are enough to attach the patch."

One of the people given the patch died, and a study of the heart showed "remarkable new blood vessel formation," Griffith said. "We had generally very positive outcomes."

A second round of human trials has begun, said Dr. Gary Gentzkow, chief medical officer of Theregen. One trial is designed to study the effect of the patch on heart function. The second trial is intended to get a detailed look at heart tissue after the patch is applied. The subjects are people with heart conditions severe enough to require implanted heart-assist devices.

The trials are being done at several medical centers in the United States, Gentzkow said. "Enrollment is finished in the studies," he said. "We are in the follow-up phase. We expect complete follow-up results this year."

Further human studies depend on the results of those trials, Gentzkow said.

More information

Current heart attack treatments are described by the U.S. Heart, Lung, and Blood Institute.



SOURCES: Jordan J. Lancaster, predoctoral fellow, Arizona VA Medical Center, Tucson; Bartley P. Griffith, M.D., chief, cardiac surgery, University of Maryland, Baltimore; Gary Gentzkow, M.D., chief medical officer, Theregen Inc., San Francicso; July 30, 2008, American Heart Association's Basic Cardiovascular Sciences Conference, Keystone, Colo.


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. China Sky One Medical, Inc. Receives SFDA Approval for Five Patches
2. Rotigotine Skin Patch May Ease Restless Legs Symptoms
3. Patch Form of HRT Poses Less Clotting Risks Than Pill Does
4. The First QPatch HT in China Placed in WuXi PharmaTech (NYSE: WX)
5. Iomai Wins Department of Defense Grant to Develop a Stable, Patch-Based Anthrax Vaccine
6. Study Finds Single Dose of Iomai Patch With Pandemic Flu Vaccine Achieves Protective Levels
7. Mylan Confirms Its Matrix Design Fentanyl Patch Is Not Included In the Widespread Recall Announced February 12th
8. PriCara(TM) Recalls 25 mcg/hr DURAGESIC(R) (fentanyl transdermal system) CII Pain Patches
9. Iomai Study Shows Self-Applied Travelers Diarrhea Vaccine Patch Comparable to Clinician-Applied Vaccine Patch
10. Ringing endorsement: Women prefer contraceptive ring over patch
11. FDA Warns Clot Risk Higher in Birth Control Patch Than Pill
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Patch Helps Mend Damaged Hearts
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... DevOps and Agile Software Development, has been awarded a contract by the Center ... Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company ... of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every ... meet the highest standard. , These products are also: Gluten Free, Non-GMO, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
(Date:10/12/2017)... PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B ... York City on October 11, 2017. , The annual award competition recognizes editorial and ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... -- According to the Centers for Disease Control and Prevention (CDC), influenza ... Care is helping communities across Massachusetts , ... no-cost* flu shots through the end of the month. *Some ... ... flu shot is by the end of October, according to the Centers ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
(Date:9/27/2017)... Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global digital ... its MyDario product is expected to appear on The Dr. Oz Show ... Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked off ... The segment features ...
Breaking Medicine Technology: