Navigation Links
Passive smoking impairs children's responses to asthma treatment
Date:2/14/2014

Children exposed to cigarette smoke at home have lower levels of an enzyme that helps them respond to asthma treatment, a study has found.

Passive smoking is known to worsen asthma symptoms in children and impair their response to inhaled steroid treatment, but how this effect occurs was not known.

Researchers at Imperial College London found that children with severe asthma with a parent who smokes at home have lower levels of the enzyme HDAC2 compared with those whose parents don't smoke. HDAC2 is required for steroids to exert their beneficial anti-inflammatory effects in asthma.

The findings are reported in the journal Chest.

Professor Peter Barnes FRS, from the National Heart and Lung Institute at Imperial College London, said: "The mechanism we've identified makes children less sensitive to inhaled steroid treatment, so they suffer more symptoms and might have to take higher doses of steroids, which may lead to side effects.

"These findings underline the importance of legislation aimed at protecting children from being exposed to cigarette smoke. Restricting smoking in cars is a positive step, but the same should be applied in homes."

Over a million children in the UK have asthma. Steroid treatments, usually taken using inhalers, are given to prevent asthma attacks, but for many patients, they aren't completely effective.

The Imperial researchers studied 19 children with severe asthma receiving treatment at Royal Brompton Hospital in London. Nine had parents who smoked at home and 10 were from non-smoking households.

Cells from the lungs of children exposed to second-hand smoke had about half the levels of HDAC2 enzymes as those from children from non-smoking families.

"Children with asthma who are passively exposed to cigarette smoke have the same molecular abnormalities that lead to steroid resistance as adults who actively smoke," said Professor Barnes. "The mechanism we've identified will be a target for new treatments to help children with severe asthma."


'/>"/>

Contact: Sam Wong
sam.wong@imperial.ac.uk
44-207-594-2198
Imperial College London
Source:Eurekalert

Related medicine news :

1. Passive smoking also affects neurodevelopment in babies
2. Passive smoking increases risk of severe dementia, according to study in China
3. Anti-tobacco TV ads help adults stop smoking, study finds
4. Exercise helps smokers to quit smoking, to remain smoke-free and to reduce the risk of death
5. Small neural focus groups predict anti-smoking ad success
6. Some women may be genetically predisposed to smoking-related hot flashes
7. Friends Parents Can Sway Teens Odds for Drinking, Smoking
8. Fewer Young Americans Smoking, Survey Finds
9. Vitamin C improves pulmonary function in newborns of pregnant smoking women
10. Genetic marker may predict smoking quantity in African Americans
11. 5 percent of workers gave up smoking when the anti-tobacco law took effect
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 27, 2016 , ... TherapySites, the leading website ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to ... adding exclusive benefits and promotional offers. , "TCA is extremely excited about this ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever ... Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation ... as home to some of the world’s leading providers of cereal and other breakfast ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
Breaking Medicine Technology: