Navigation Links
Parkinson's Patients Experience Declines Years Before Diagnosis
Date:7/6/2012

FRIDAY, July 6 (HealthDay News) -- Parkinson's disease patients experience declines in physical abilities and quality of life several years before the degenerative disease is diagnosed, new research finds.

In women, the declines started about 7.5 years before diagnosis, while in men, declines were noted at three years prior to diagnosis, according to the study in the June 2 issue of the Journal of Parkinson's Disease.

Parkinson's disease occurs when the neurons that produce dopamine, a crucial brain chemical, in certain regions of the brain die. Symptoms, which worsen over time, can include tremors, stiffness, slurred speech and trouble walking.

Researchers examined information on 51,000 men enrolled in the Health Professionals Follow Up Study and 122,000 women enrolled in the Nurses' Health Study.

The men completed questionnaires about their health-related quality of life, including physical functioning, limitations due to physical and emotional problems, mental health issues and pain. The women answered questions about their physical functioning.

Researchers identified 454 men and 414 women with Parkinson's disease. Until about 7.5 years before diagnosis, physical function for both men and women was similar to that of men and women who were not later diagnosed with Parkinson's.

From this point on, however, women with the disease began to experience a decline in their physical function, while men's decline in physical function and well-being began around three years prior to diagnosis.

"We observed a decline in physical function in [Parkinson's disease] patients relative to their healthy counterparts beginning three years prior to diagnosis in men and seven and a half years prior to diagnosis in women," study lead investigator Natalia Palacios, of Harvard School of Public Health, said in a journal news release. "The decline continues at a rate that is five to seven times faster than the average yearly decline caused by normal aging in individuals without the disease."

Researchers said the study suggests that the Parkinson's disease process may start years before symptoms become obvious.

"This result provides support to the notion that the pathological process leading to PD [Parkinson's disease] may start several years before PD diagnosis," Palacios concluded. "Our hope is that, with future research, biological markers of the disease process may be recognizable in this preclinical phase."

More information

The U.S. National Institute on Neurological Disorders and Stroke provides more information on Parkinson's disease.

-- Mary Elizabeth Dallas

SOURCE: Journal of Parkinson's Disease, news release, July 2, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Extra Pounds May Offer Protection to Heart Failure Patients
2. Fingolimod: Hint of advantages in a small group of patients
3. Obesity, larger waist size associated with better outcomes in heart failure patients
4. Northwestern launches comprehensive program for patients with bicuspid aortic valve disease
5. Botox May Ease Tremors in Multiple Sclerosis Patients
6. ACP Immunization Advisor app makes it easier for doctors to identify vaccines for patients
7. A better way to test new treatments? Approach could help patients and give useful results
8. Years before diagnosis, quality of life declines for Parkinsons disease patients
9. Virtual Colonoscopy Safe, Effective for Medicare Patients: Study
10. Analysis of KRYSTEXXA phase III data demonstrates improved health-related quality of life and physical function in refractory chronic gout patients
11. Few Patients Should Get Metal-on-Metal Hip Implants, FDA Panel Says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
(Date:6/24/2016)... ... ... recruitment firm Slone Partners is pleased to announce the placement of Suzanne ... of North American Capital Sales at HTG Molecular . , In ... commercialization of the HTG EdgeSeq system and associated reagents in North America. , Headquartered ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016 /PRNewswire/ ... pulmonary function testing company, is now able to perform sophisticated lung ... ndd Medical Technologies , Inc. Patients are ... labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients like ... any needed testing done in the comfort of her own home. ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
Breaking Medicine Technology: