Navigation Links
Parkinson's Linked to Genetic Mutation
Date:4/2/2010

In mice, researchers see tie-in to tremors and other motor problems

FRIDAY, April 2 (HealthDay News) -- New details about how a mutation in a gene called LRRK2 may cause Parkinson's disease have been uncovered by U.S. researchers.

In experiments using genetically engineered mice, the Mount Sinai School of Medicine team found that LRRK2 regulates dopamine transmission and controls motor performance. Dopamine is a neurotransmitter. The mutation eliminates the normal function of LRRK2, resulting in inherited (familial) Parkinson's, the most common form of the disease.

The study was published in The Journal of Neuroscience.

The mice created and used by the Mount Sinai researchers feature a key element of Parkinson's disease -- age-dependent reduction of dopamine -- which is believed to cause the motor function problems, such as tremors, rigidity, and involuntary movement experienced by people with Parkinson's.

"While the mice are not at the stage where they experience the typical symptoms of Parkinson's, like tremors or reduced movement, we are able to study the potential root cause of the disease in these mice," Zhenyu Yue, an associate professor of neurology and neuroscience, said in a Mount Sinai news release.

"Importantly, as we have developed assays that allow us to measure the enzymatic activity of LRRK2 in the brain, the mouse models provide valuable tools in the preclinical development of drug compounds that target aberrant LRRK2 activity. This research may translate to non-familial Parkinson's disease as well," Yue added.

More information

We Move has more about Parkinson's disease.



-- Robert Preidt



SOURCE: Mount Sinai Medical Center, news release, March 31, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Agricultural Chemical Spray Linked to Birth Defect Risk
2. 3 brain diseases linked by toxic form of same neural protein
3. Bad Behavior as a Kid Linked to Early Death in Men
4. Sedation Linked to Longer Stay in ICU
5. Personal History Linked to Feelings of Betrayal
6. Improved air quality linked to fewer pediatric ear infections
7. Flame-Retardant Chemical Linked to Conception Problems
8. Common antidepressant drugs linked to lactation difficulties in moms
9. Vitamin D Linked to Survival in Lymphoma Patients
10. Poop dermatitis linked to fashionable toilet seats, harsh chemicals
11. Self-Image Linked to Activity in Frontal Lobe of Brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... , ... The producers of Enterprises TV are pleased to present ... world of instantaneous consumption proves very convenient for businesses. With new technologies constantly becoming ... which pollutes our air, water, and soil. It can also threaten the lives of ...
(Date:2/13/2016)... ... 13, 2016 , ... DDi , a Makro company, ... for its expertise in eClinical Solutions. DDi has built its solution competency with ... of global clients. DDi provides smarter technology for Clinical Development, Regulatory and Enterprise ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... to funding innovative lymphoma research and serving the lymphoma community through a comprehensive ... members of South Florida’s philanthropic community at its 10th anniversary Fashion Luncheon on ...
(Date:2/12/2016)... ... February 12, 2016 , ... Coco Libre, the maker ... Red Carpet Events LA GRAMMY’s Style Lounge Event. Coco Libre will offer musicians and ... hydrated before the big event. The invitation-only gifting suite, held this year at the ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Fisher House ... Vegas Mayor John J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy ... at the VA Southern Nevada Healthcare System. This will be the first Fisher ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Feb. 12, 2016   National Community Pharmacists Association ... MBA issued the following statement today in response to ... the Centers for Medicare & Medicaid Services (CMS) ... beneficiary advocates and others: patient advocacy organizations ... still reviewing the full CMS analysis. Our initial reaction ...
(Date:2/12/2016)... , Feb. 12, 2016  Diplomat Pharmacy, Inc. (NYSE: DPLO ) is pleased to ... Account Management and Payor Strategies effective Jan. 23, 2016. ... ... ... Diplomat Specialty Pharmacy ...
(Date:2/12/2016)... MONTREAL , February 12, 2016 ... sofern nicht anders vermerkt)   ... Unternehmens http://www.telestatherapeutics.com abrufbar.    ... Website des Unternehmens http://www.telestatherapeutics.com ... Inc. (TSX:TST; PNK:BNHLF) veröffentlichte heute seinen Konzernabschluss ...
Breaking Medicine Technology: