Navigation Links
Parkinson's Linked to Genetic Mutation
Date:4/2/2010

In mice, researchers see tie-in to tremors and other motor problems

FRIDAY, April 2 (HealthDay News) -- New details about how a mutation in a gene called LRRK2 may cause Parkinson's disease have been uncovered by U.S. researchers.

In experiments using genetically engineered mice, the Mount Sinai School of Medicine team found that LRRK2 regulates dopamine transmission and controls motor performance. Dopamine is a neurotransmitter. The mutation eliminates the normal function of LRRK2, resulting in inherited (familial) Parkinson's, the most common form of the disease.

The study was published in The Journal of Neuroscience.

The mice created and used by the Mount Sinai researchers feature a key element of Parkinson's disease -- age-dependent reduction of dopamine -- which is believed to cause the motor function problems, such as tremors, rigidity, and involuntary movement experienced by people with Parkinson's.

"While the mice are not at the stage where they experience the typical symptoms of Parkinson's, like tremors or reduced movement, we are able to study the potential root cause of the disease in these mice," Zhenyu Yue, an associate professor of neurology and neuroscience, said in a Mount Sinai news release.

"Importantly, as we have developed assays that allow us to measure the enzymatic activity of LRRK2 in the brain, the mouse models provide valuable tools in the preclinical development of drug compounds that target aberrant LRRK2 activity. This research may translate to non-familial Parkinson's disease as well," Yue added.

More information

We Move has more about Parkinson's disease.



-- Robert Preidt



SOURCE: Mount Sinai Medical Center, news release, March 31, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Agricultural Chemical Spray Linked to Birth Defect Risk
2. 3 brain diseases linked by toxic form of same neural protein
3. Bad Behavior as a Kid Linked to Early Death in Men
4. Sedation Linked to Longer Stay in ICU
5. Personal History Linked to Feelings of Betrayal
6. Improved air quality linked to fewer pediatric ear infections
7. Flame-Retardant Chemical Linked to Conception Problems
8. Common antidepressant drugs linked to lactation difficulties in moms
9. Vitamin D Linked to Survival in Lymphoma Patients
10. Poop dermatitis linked to fashionable toilet seats, harsh chemicals
11. Self-Image Linked to Activity in Frontal Lobe of Brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Bracket , ... launch its next generation clinical outcomes platform, Bracket eCOA (SM) ... held on June 26 – 30, 2016 in ... first electronic Clinical Outcome Assessment product of its kind to ... #715. Bracket eCOA 6.0 is a flexible platform ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
(Date:6/23/2016)... 2016 Revolutionary technology includes multi-speaker ... , industry leaders in advanced audiology and hearing aid ... Opn ™, the world,s first internet connected hearing aid ... devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) ... of ,world firsts,: , TwinLink™ - the ...
Breaking Medicine Technology: