Navigation Links
Parkinson's Linked to Genetic Mutation
Date:4/2/2010

In mice, researchers see tie-in to tremors and other motor problems

FRIDAY, April 2 (HealthDay News) -- New details about how a mutation in a gene called LRRK2 may cause Parkinson's disease have been uncovered by U.S. researchers.

In experiments using genetically engineered mice, the Mount Sinai School of Medicine team found that LRRK2 regulates dopamine transmission and controls motor performance. Dopamine is a neurotransmitter. The mutation eliminates the normal function of LRRK2, resulting in inherited (familial) Parkinson's, the most common form of the disease.

The study was published in The Journal of Neuroscience.

The mice created and used by the Mount Sinai researchers feature a key element of Parkinson's disease -- age-dependent reduction of dopamine -- which is believed to cause the motor function problems, such as tremors, rigidity, and involuntary movement experienced by people with Parkinson's.

"While the mice are not at the stage where they experience the typical symptoms of Parkinson's, like tremors or reduced movement, we are able to study the potential root cause of the disease in these mice," Zhenyu Yue, an associate professor of neurology and neuroscience, said in a Mount Sinai news release.

"Importantly, as we have developed assays that allow us to measure the enzymatic activity of LRRK2 in the brain, the mouse models provide valuable tools in the preclinical development of drug compounds that target aberrant LRRK2 activity. This research may translate to non-familial Parkinson's disease as well," Yue added.

More information

We Move has more about Parkinson's disease.



-- Robert Preidt



SOURCE: Mount Sinai Medical Center, news release, March 31, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Agricultural Chemical Spray Linked to Birth Defect Risk
2. 3 brain diseases linked by toxic form of same neural protein
3. Bad Behavior as a Kid Linked to Early Death in Men
4. Sedation Linked to Longer Stay in ICU
5. Personal History Linked to Feelings of Betrayal
6. Improved air quality linked to fewer pediatric ear infections
7. Flame-Retardant Chemical Linked to Conception Problems
8. Common antidepressant drugs linked to lactation difficulties in moms
9. Vitamin D Linked to Survival in Lymphoma Patients
10. Poop dermatitis linked to fashionable toilet seats, harsh chemicals
11. Self-Image Linked to Activity in Frontal Lobe of Brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... ... is bolstered by inspiring human-interest stories, courtesy of awareness-driven celebrities and thought leaders. ... from leading advocates, associations and industry leaders such as Bioness. , As ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... is bolstered by inspiring human interest stories, courtesy of leaders in the nursing ... tech within the industry, from leading advocates and associations—namely Jones & Bartlett Learning. ...
(Date:5/27/2016)... ... ... With a team of certified experts, Validation Center is ... GMP accreditation, Validation Center is also a registered authority of the international system ... Validation Center is ISO17025 accredited and only offers its clients the latest technology, ...
(Date:5/26/2016)... ... May 26, 2016 , ... W.S. Badger Co. Inc ., the maker ... 2016 When Work Works Award for its use of effective workplace strategies to increase ... Works project administered by the Families and Work Institute (FWI) and the Society for ...
(Date:5/26/2016)... ... May 26, 2016 , ... Georgia State University College of ... programs. , Answering to the increasing demand for curricular specializations, the Certificate in ... environmental and land use law. ,  , “The demand for lawyers with specific ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016  According to Kalorama Information, ... billion in 2015.  Though these are challenging times ... opportunity for success for companies that remain optimistic ... of new growth prospects medical device companies spend ... and development (R&D) than do companies in other ...
(Date:5/25/2016)... 25, 2016 Digital Health Dialog, LLC ... by the US Patent and Trademark Office of ... proprietary processes for electronic opt-­in and processing of ... programs, HIPAA compliance and otherwise. Logo - ... "Our technology allows for individuals to ...
(Date:5/24/2016)... , May 24, 2016 ... Markt gebracht, die es Ärzten erlaubt, ihre Expertise ... behandeln: MDLinking kombiniert Live Streaming mit einer Instant-Messaging-Funktion ... zu kommunizieren. Mediziner in Europa, Afrika, Asien und ... bereits für die Plattform registriert. Information ...
Breaking Medicine Technology: