Navigation Links
Parkinson's Drug May Fight Cancer
Date:3/15/2008

Dopamine prevents tumors from gaining a blood supply, studies suggest

SATURDAY, March 15 (HealthDay News) -- The drug dopamine -- currently used to treat patients with conditions such as Parkinson's disease, pituitary tumors and heart attack -- may also prove effective in cancer patients, a Mayo Clinic study finds.

In laboratory and mouse tests, researchers found dopamine can help prevent the development of new blood vessels, something that would slow the progression of cancer. The findings were published in the online edition of the Journal of Clinical Investigation.

"Researchers can now test this concept in solid tumors where angiogenesis (formation of new blood vessels) plays a critical role in the growth and progression of these cancers," Dr. Sujit Basu, a Mayo Clinic oncologist, said in a prepared statement.

Specifically, Basu and colleagues found that dopamine prevents the transfer of endothelial progenitor cells (which help form new blood vessels) from bone marrow into the circulatory system. The drug does this by binding to a specific receptor on the surface of the progenitor cells. This suppresses the activity of an enzyme (MMP-9) that enables the progenitor cells to move out of bone marrow.

In their experiments, the researchers found that dopamine significantly decreased movement of progenitor cells from bone marrow and decreased MMP-9 expression.

"Sometimes new drugs may not be the answer. We looked instead at a novel use for an established product, and have found very promising results," Basu said.

Natural dopamine is a neurotransmitter in the brain that regulates movement and affects behavior. The drug is a synthetic form of the natural brain chemical.

"This is the first time it has been shown that an important neurotransmitter like dopamine is regulating the mobilization of these progenitor cells from the bone marrow. This is very important, and represents why these findings are so unique," Basu said.

More information

The U.S. National Cancer Institute has more about angiogenesis.



-- Robert Preidt



SOURCE: Mayo Clinic, news release, March 13, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Preclinical study suggests organ-transplant drug may aid in lupus fight
2. Computers help chemists fight emerging infections
3. Study shines more light on benefit of vitamin D in fighting cancer
4. Texas Supreme Court Rules Against Medicare HMOs in Hospital Reimbursement Fight
5. HIV Drug Might Fight Cancer
6. ADA Challenges Marylanders to Step Out to Fight Diabetes Epidemic
7. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
8. Drug, Pacemaker Fight Irregular Heartbeat
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. The fight against colorectal cancer
11. Especially Yours and Paula Young Team up with Diahann Carroll and Jaclyn Smith in the Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Parkinson's Drug May Fight Cancer
(Date:5/26/2017)... ... May 26, 2017 , ... Water damage to the flooring of several ... had left education officials with a number of critical issues to address before students ... to be accomplished with little or no disruption to class schedules. Second, the project ...
(Date:5/24/2017)... ... May 24, 2017 , ... In modern research, success depends ... instruments for research and understanding the basic principles that were designed to drive ... innovations in stereo microscopy for brightfield and fluorescence typically used in laboratories working ...
(Date:5/24/2017)... ... 24, 2017 , ... Altec Products, Inc., a leader in enterprise ... one-day technology conference in San Diego, CA. , At nVerge 2017, Altec will ... utilize and enhance their Sage ERP solutions by providing improved visibility and control to ...
(Date:5/24/2017)... ... May 24, 2017 , ... Drs. ... NY, who have now spent 10 years as clinical instructors for the reputable ... College of Dentistry. Through the program, private practitioners receive cutting-edge clinical training and ...
(Date:5/24/2017)... ... , ... Patients who want to receive cosmetic dentistry procedures such as Invisalign® ... for a consultation, with or without a referral. Dr. Bedich enjoys improving the appearance ... , Dr. Bedich offers a variety of cosmetic dentistry services at his practice that ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... MARLBOROUGH, Mass., May 10, 2017 Hologic, Inc. ... financial results for the fiscal second quarter ended April ... (EPS) of $1.84 increased 666.7% compared to the prior ... business resulted in a significant gain, while non-GAAP diluted ... increased 3.2%, or 3.8% in constant currency terms.  Excluding ...
(Date:5/10/2017)... Md. , May 10, 2017 CSSi, ... solutions for the clinical research industry, is proud to ... www.CSSiEnroll.com . The new website features both enriched content ... user experience and enhances the company,s already well-established position ... industry. "After many months of hard ...
(Date:5/9/2017)... 9, 2017  Semler Scientific, Inc. (OTCQB: SMLR), ... to improve the clinical effectiveness and efficiency of ... first quarter ended March 31, 2017. ... customers to identify when preventive care options are ... like heart attacks or strokes occur," said ...
Breaking Medicine Technology: