Navigation Links
Parkinson's Drug May Fight Cancer
Date:3/15/2008

Dopamine prevents tumors from gaining a blood supply, studies suggest

SATURDAY, March 15 (HealthDay News) -- The drug dopamine -- currently used to treat patients with conditions such as Parkinson's disease, pituitary tumors and heart attack -- may also prove effective in cancer patients, a Mayo Clinic study finds.

In laboratory and mouse tests, researchers found dopamine can help prevent the development of new blood vessels, something that would slow the progression of cancer. The findings were published in the online edition of the Journal of Clinical Investigation.

"Researchers can now test this concept in solid tumors where angiogenesis (formation of new blood vessels) plays a critical role in the growth and progression of these cancers," Dr. Sujit Basu, a Mayo Clinic oncologist, said in a prepared statement.

Specifically, Basu and colleagues found that dopamine prevents the transfer of endothelial progenitor cells (which help form new blood vessels) from bone marrow into the circulatory system. The drug does this by binding to a specific receptor on the surface of the progenitor cells. This suppresses the activity of an enzyme (MMP-9) that enables the progenitor cells to move out of bone marrow.

In their experiments, the researchers found that dopamine significantly decreased movement of progenitor cells from bone marrow and decreased MMP-9 expression.

"Sometimes new drugs may not be the answer. We looked instead at a novel use for an established product, and have found very promising results," Basu said.

Natural dopamine is a neurotransmitter in the brain that regulates movement and affects behavior. The drug is a synthetic form of the natural brain chemical.

"This is the first time it has been shown that an important neurotransmitter like dopamine is regulating the mobilization of these progenitor cells from the bone marrow. This is very important, and represents why these findings are so unique," Basu said.

More information

The U.S. National Cancer Institute has more about angiogenesis.



-- Robert Preidt



SOURCE: Mayo Clinic, news release, March 13, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Preclinical study suggests organ-transplant drug may aid in lupus fight
2. Computers help chemists fight emerging infections
3. Study shines more light on benefit of vitamin D in fighting cancer
4. Texas Supreme Court Rules Against Medicare HMOs in Hospital Reimbursement Fight
5. HIV Drug Might Fight Cancer
6. ADA Challenges Marylanders to Step Out to Fight Diabetes Epidemic
7. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
8. Drug, Pacemaker Fight Irregular Heartbeat
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. The fight against colorectal cancer
11. Especially Yours and Paula Young Team up with Diahann Carroll and Jaclyn Smith in the Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Parkinson's Drug May Fight Cancer
(Date:7/24/2017)... ... July 24, 2017 , ... A CDC study shows that, although people are taking ... (ages 18 to 29), had at least one case of sunburn within the past year. ... causes people to ignore the issue. However, only recently have people become conscientious of the ...
(Date:7/24/2017)... ... ... Anyone who uses scales know they have limits; a small kitchen scale ... scale to dispense medication. The first example is an issue of capacity, while the ... important to have the right balance for the process. METTLER TOLEDO’s new white paper, ...
(Date:7/24/2017)... ... July 24, 2017 , ... Sharon Kleyne, host of the nationally ... on VoiceAmerica sponsored by Nature’s Tears® EyeMist® recently talked on the air about an ... China. , The article by Zidor Aldama described the situation in which Chinese children ...
(Date:7/24/2017)... ... 2017 , ... Paul Vitenas, MD, FACS is excited to report that he ... attend Allergan’s recent meeting with their Plastics Advisory Board. As one of the top ... bringing a newly defined structure to the aesthetics market. Dr. Vitenas , along ...
(Date:7/24/2017)... ... July 24, 2017 , ... The Magic Wand® Rechargeable, the ... for favorite sex toy. Created in collaboration with website Kinkly.com, the award was ... voted. The Magic Wand Rechargeable won in stiff competition from brands such as ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... 12, 2017 CarpalAID is a revolutionary new product that ... Carpal tunnel syndrome affects more than 8 million people ... rate of men. The common methods of treating CTS are painful ... hand braces or gloves. ... CarpalAID is a clear patch worn on the ...
(Date:7/11/2017)... ROCKVILLE, Md. , July 11, 2017  The ... had estimated revenues of approximately $394.1 million in 2016.  ... a trend of solid growth, in particular as a ... oncology clinical practice, and the recent introduction of a ... the need for less-invasive testing of tumor biomarkers to ...
(Date:7/10/2017)...  US medical equipment and supply demand is forecast ... Medical Equipment & Supplies: United States , ... increases in demand for medical services – driven in ... supported by gains in disposable personal income – will ... introductions will also drive sales as providers and patients ...
Breaking Medicine Technology: