Navigation Links
Parkinson's Drug May Fight Cancer
Date:3/15/2008

Dopamine prevents tumors from gaining a blood supply, studies suggest

SATURDAY, March 15 (HealthDay News) -- The drug dopamine -- currently used to treat patients with conditions such as Parkinson's disease, pituitary tumors and heart attack -- may also prove effective in cancer patients, a Mayo Clinic study finds.

In laboratory and mouse tests, researchers found dopamine can help prevent the development of new blood vessels, something that would slow the progression of cancer. The findings were published in the online edition of the Journal of Clinical Investigation.

"Researchers can now test this concept in solid tumors where angiogenesis (formation of new blood vessels) plays a critical role in the growth and progression of these cancers," Dr. Sujit Basu, a Mayo Clinic oncologist, said in a prepared statement.

Specifically, Basu and colleagues found that dopamine prevents the transfer of endothelial progenitor cells (which help form new blood vessels) from bone marrow into the circulatory system. The drug does this by binding to a specific receptor on the surface of the progenitor cells. This suppresses the activity of an enzyme (MMP-9) that enables the progenitor cells to move out of bone marrow.

In their experiments, the researchers found that dopamine significantly decreased movement of progenitor cells from bone marrow and decreased MMP-9 expression.

"Sometimes new drugs may not be the answer. We looked instead at a novel use for an established product, and have found very promising results," Basu said.

Natural dopamine is a neurotransmitter in the brain that regulates movement and affects behavior. The drug is a synthetic form of the natural brain chemical.

"This is the first time it has been shown that an important neurotransmitter like dopamine is regulating the mobilization of these progenitor cells from the bone marrow. This is very important, and represents why these findings are so unique," Basu said.

More information

The U.S. National Cancer Institute has more about angiogenesis.



-- Robert Preidt



SOURCE: Mayo Clinic, news release, March 13, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Preclinical study suggests organ-transplant drug may aid in lupus fight
2. Computers help chemists fight emerging infections
3. Study shines more light on benefit of vitamin D in fighting cancer
4. Texas Supreme Court Rules Against Medicare HMOs in Hospital Reimbursement Fight
5. HIV Drug Might Fight Cancer
6. ADA Challenges Marylanders to Step Out to Fight Diabetes Epidemic
7. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
8. Drug, Pacemaker Fight Irregular Heartbeat
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. The fight against colorectal cancer
11. Especially Yours and Paula Young Team up with Diahann Carroll and Jaclyn Smith in the Fight Against Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Parkinson's Drug May Fight Cancer
(Date:5/26/2016)... ... May 26, 2016 , ... On Memorial Day, Hope For ... their lives in military battle for the country. The nonprofit Hope For Heroes ... more programs that empower independence for disabled military veterans, as well as police, firemen, ...
(Date:5/26/2016)... ... 2016 , ... Cardiac arrhythmia is a common complication following ... survival, reports a team of UPMC researchers in the largest study of its ... Thoracic and Cardiovascular Surgery, provide critical information that will hopefully lead to better ...
(Date:5/26/2016)... ... May 26, 2016 , ... MadgeTech will be showcasing its line ... in Warner, New Hampshire at the MadgeTech headquarters. With products sold in more than ... by government agencies, including NASA. , In 2012, NASA strategically set up 17 ...
(Date:5/26/2016)... ... May 26, 2016 , ... Dr. James ... Fighting Blindness, Long Island Chapter on June 4, 2016, 1:30-3:30 pm at the ... founder of Retina Group of New York , is a Board Certified ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... In an effort to provide hair restoration ... to both Snapchat users and those who do not use the app. Dr. Mohebi, the ... new page, Dr. Mohebi Live . , Dr. Mohebi says, “The positive response ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 Amarantus BioScience ... on developing products for Regenerative Medicine, Neurology and Orphan Diseases, today ... be presenting at two upcoming investor conferences: SeeThru ... Third Avenue, New York City , NY ... Marcum MicroCap Conference   Where: Grand Hyatt ...
(Date:5/26/2016)... May 26, 2016 According to a ... Management Market - U.S. Industry Analysis, Size, Share, Growth, Trends, ... in the U.S. was valued at US$ 5.89 Bn in ... 3.4% from 2015 to 2023 to reach US$ 7.99 Bn ... current and emerging needle free drug delivery devices and the ...
(Date:5/26/2016)... -- TARE (Transarterial Radio-embolization) Using Yttrium-90 ... Overall Decreased Use of Hospital Resource ... healthcare company, has today announced the publication of ... ISPOR (International Society for Pharmacoeconomics and Outcomes Research), ... yttrium-90 glass microspheres is associated with cost savings ...
Breaking Medicine Technology: