Navigation Links
Parkinson's Disrupts Stem Cell Therapy Transplants
Date:4/6/2008

Dopamine neurons may not work long-term, as disease causes pathologic changes in cells

SUNDAY, April 6 (HealthDay News) -- Current therapies using stem cell transplants in the brains of patients with Parkinson's disease may not work long-term, because the disease is an ongoing process that continually causes damage, new findings suggest.

Dopamine cells are sometimes transplanted into the brain of Parkinson's patients in the hope that they can replace those neurons that have degenerated. In theory, this should improve the disease's symptoms, which include tremors, stiffness of the limbs and trunk, slowed movement and impaired balance and coordination.

Researchers at Mount Sinai School of Medicine in New York City and Rush University Medical Center in Chicago studied brain tissue from a patient who had received a dopamine transplant 14 years earlier and found that the transplanted cells developed changes characteristic of Parkinson's disease (PD) and did not appear to function normally.

The patient had improved initially after the transplant but then deteriorated, noted the study, published in the April issue of Nature Medicine.

"While, on the one hand, these results may sound disappointing, this information is crucially important if we are to develop better therapies for PD. The more knowledge we gain about the nature of the disease, the better our chances to find the cause of why cells degenerate and to develop a treatment that can protect them," Dr. C. Warren Olanow, director of the Robert and John M. Bendheim Parkinson's Disease Center at Mount Sinai School of Medicine, said in a prepared statement. "These findings also do not mean that transplant strategies such as stem cells cannot be made to work -- our findings just represent another obstacle that will have to be overcome."

According to researchers, these new findings counter the theory that a single event, like an infection, causes the initial damage to cells and triggers their gradual degeneration over time. Since the newly implanted cells in the Parkinson's patient also became damaged, they suggest that the disease process is ongoing.

More information

The National Institute of Neurological Disorders and Stroke has more about Parkinson's disease.



-- Kevin McKeever



SOURCE: Mount Sinai Medical Center, news release, April 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. How DDT metabolite disrupts breast cancer cells
2. Antibacterial chemical disrupts hormone activities
3. Nicotine in breast milk disrupts infants sleep patterns
4. Occupational Therapy Month 2008 Highlights Profession as Career Choice
5. SEISMIC study issues glum report on cell therapy
6. 2-drug blood pressure therapy lowers cardiovascular risk
7. Positive results from Visudyne(R) combination therapy study reported at Annual Macula Society Conference
8. BioLife Solutions Expands Presence in Cell Therapy and Cord Blood Banking Market Segments
9. Ukiah Home Oxygen Therapy Patients and Physicians Meet with Congressman Mike Thompson to Share Benefits of Quality Home Oxygen Care
10. Drug Therapy Boosting Heart-Attack Survival Rates
11. ClearScript Offers Innovative Medication Therapy Management Program to Employee Health Plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... WA (PRWEB) , ... January 16, 2017 , ... NexTec ... 2016, a group of 100 organizations honored for their accomplishments in the field of ... such growth, industry leadership and recognition, and innovation. Selection is not based on revenue ...
(Date:1/15/2017)... ... January 15, 2017 , ... Accreditation Commission ... accreditation for its specialty care services. Albertsons Companies is the largest national ... service for pharmacy patients. , Accreditation by ACHC reflects Albertsons Companies’ dedication and ...
(Date:1/15/2017)... ... 15, 2017 , ... The Gravity Vault Indoor Rock Climbing Gym is excited ... up on the 14,000+ square foot climbing gym, the owners anticipate to open sometime ... New Jersey and two in New York. With this being its first location in ...
(Date:1/14/2017)... ... 14, 2017 , ... AgileMinder develops innovative products and services that bring "Care, ... available on Apple as a fun, free emoji sticker pack for iMessage. Use the ... ten color coded values on The Emoji Scale. , On Apple: "The Emoji ...
(Date:1/13/2017)... ... January 13, 2017 , ... A January 10 ... procedures for 2017 according to the publication, with an emphasis on some new techniques ... M.D., F.I.C.S., F.A.C.S., who is known more casually to his patients and colleagues as ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... Bill is an internationally experienced medical device industry executive who ... global medical device companies, including Smith & Nephew, Angiodynamics, Orthovita and ... and building successful businesses in the sector and has worked in ... North America . ... Educated at the University of Edinburgh (Dental Surgery), ...
(Date:1/16/2017)... Calif. , Jan. 16, 2017  Rigel Pharmaceuticals ... January 3, 2017 and January 16, 2017 the Compensation ... of inducement stock options to purchase an aggregate of ... These awards were granted pursuant to the Rigel Pharmaceuticals, ... to the new employees entering into employment with Rigel, ...
(Date:1/15/2017)... January 16, 2017 Der Vorstand ... für die Regeneration des menschlichen Gewebes, gibt die Ernennung ... sofortiger Wirkung bekannt. ... Bill Allan ist ... bekleidete eine Reihe von Geschäftsführer- und anderen Führungspositionen bei ...
Breaking Medicine Technology: