Navigation Links
Parkinson's Disrupts Stem Cell Therapy Transplants
Date:4/6/2008

Dopamine neurons may not work long-term, as disease causes pathologic changes in cells

SUNDAY, April 6 (HealthDay News) -- Current therapies using stem cell transplants in the brains of patients with Parkinson's disease may not work long-term, because the disease is an ongoing process that continually causes damage, new findings suggest.

Dopamine cells are sometimes transplanted into the brain of Parkinson's patients in the hope that they can replace those neurons that have degenerated. In theory, this should improve the disease's symptoms, which include tremors, stiffness of the limbs and trunk, slowed movement and impaired balance and coordination.

Researchers at Mount Sinai School of Medicine in New York City and Rush University Medical Center in Chicago studied brain tissue from a patient who had received a dopamine transplant 14 years earlier and found that the transplanted cells developed changes characteristic of Parkinson's disease (PD) and did not appear to function normally.

The patient had improved initially after the transplant but then deteriorated, noted the study, published in the April issue of Nature Medicine.

"While, on the one hand, these results may sound disappointing, this information is crucially important if we are to develop better therapies for PD. The more knowledge we gain about the nature of the disease, the better our chances to find the cause of why cells degenerate and to develop a treatment that can protect them," Dr. C. Warren Olanow, director of the Robert and John M. Bendheim Parkinson's Disease Center at Mount Sinai School of Medicine, said in a prepared statement. "These findings also do not mean that transplant strategies such as stem cells cannot be made to work -- our findings just represent another obstacle that will have to be overcome."

According to researchers, these new findings counter the theory that a single event, like an infection, causes the initial damage to cells and triggers their gradual degeneration over time. Since the newly implanted cells in the Parkinson's patient also became damaged, they suggest that the disease process is ongoing.

More information

The National Institute of Neurological Disorders and Stroke has more about Parkinson's disease.



-- Kevin McKeever



SOURCE: Mount Sinai Medical Center, news release, April 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. How DDT metabolite disrupts breast cancer cells
2. Antibacterial chemical disrupts hormone activities
3. Nicotine in breast milk disrupts infants sleep patterns
4. Occupational Therapy Month 2008 Highlights Profession as Career Choice
5. SEISMIC study issues glum report on cell therapy
6. 2-drug blood pressure therapy lowers cardiovascular risk
7. Positive results from Visudyne(R) combination therapy study reported at Annual Macula Society Conference
8. BioLife Solutions Expands Presence in Cell Therapy and Cord Blood Banking Market Segments
9. Ukiah Home Oxygen Therapy Patients and Physicians Meet with Congressman Mike Thompson to Share Benefits of Quality Home Oxygen Care
10. Drug Therapy Boosting Heart-Attack Survival Rates
11. ClearScript Offers Innovative Medication Therapy Management Program to Employee Health Plans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Doctors on Liens is continuing its ... Dr. Steven H. Rauchman, practicing at North Valley Eye Medical Group in Mission ... premise liability and other personal injury cases. These injuries have a major impact ...
(Date:2/22/2017)... ... February 22, 2017 , ... The first-ever National ... organizations, advocates, and individuals join together to increase recognition about the risks of ... lives. , “Today we mark a nationwide movement to raise awareness about a ...
(Date:2/22/2017)... TX (PRWEB) , ... February 22, 2017 , ... ... the launch of ProGen™ PRP, the latest innovation in the delivery of Platelet ... wound care, aesthetics, cardiovascular and pain management, to accelerate tissue synthesis and provide ...
(Date:2/22/2017)... CT (PRWEB) , ... February 22, 2017 , ... The ... and the 2017 Forecast —on Thursday, February 23, 2017, at 1:00 PM ET. A ... webinar is part of the Interactive Webinar Series. , If you want to find ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... veterans who suffer from combat-related PTSD. , Established in 1977, our organization was ... the challenges of military returning to civilian life were evident and served as ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... , Feb 22, 2017 Research and Markets ... Analysis & Trends - Industry Forecast to 2025" report to their ... The Global Clot ... 5.2% over the next decade to reach approximately $2.1 billion by 2025. ... forecasts for all the given segments on global as well as regional ...
(Date:2/22/2017)... Research and Markets has announced the addition of the ... Trend Indicator):Analysis By Region, By Country (2016-21)" report to their ... Global ... CAGR of 5.33% during 2016-2021 The strong growth is ... demand of digital thermometer. Apart from that, the downfall in the ...
(Date:2/22/2017)... DUBLIN , Feb. 22, 2017  Allergan ... is proud to be a Gold sponsor of ... National Educating America Tour." This tour commemorates AFA,s15 ... availability of services and programs. The tour will ... free memory screenings and displays of the AFA ...
Breaking Medicine Technology: