Navigation Links
Parkinson's Disrupts Stem Cell Therapy Transplants

Dopamine neurons may not work long-term, as disease causes pathologic changes in cells

SUNDAY, April 6 (HealthDay News) -- Current therapies using stem cell transplants in the brains of patients with Parkinson's disease may not work long-term, because the disease is an ongoing process that continually causes damage, new findings suggest.

Dopamine cells are sometimes transplanted into the brain of Parkinson's patients in the hope that they can replace those neurons that have degenerated. In theory, this should improve the disease's symptoms, which include tremors, stiffness of the limbs and trunk, slowed movement and impaired balance and coordination.

Researchers at Mount Sinai School of Medicine in New York City and Rush University Medical Center in Chicago studied brain tissue from a patient who had received a dopamine transplant 14 years earlier and found that the transplanted cells developed changes characteristic of Parkinson's disease (PD) and did not appear to function normally.

The patient had improved initially after the transplant but then deteriorated, noted the study, published in the April issue of Nature Medicine.

"While, on the one hand, these results may sound disappointing, this information is crucially important if we are to develop better therapies for PD. The more knowledge we gain about the nature of the disease, the better our chances to find the cause of why cells degenerate and to develop a treatment that can protect them," Dr. C. Warren Olanow, director of the Robert and John M. Bendheim Parkinson's Disease Center at Mount Sinai School of Medicine, said in a prepared statement. "These findings also do not mean that transplant strategies such as stem cells cannot be made to work -- our findings just represent another obstacle that will have to be overcome."

According to researchers, these new findings counter the theory that a single event, like an infection, causes the initial damage to cells and triggers their gradual degeneration over time. Since the newly implanted cells in the Parkinson's patient also became damaged, they suggest that the disease process is ongoing.

More information

The National Institute of Neurological Disorders and Stroke has more about Parkinson's disease.

-- Kevin McKeever

SOURCE: Mount Sinai Medical Center, news release, April 6, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. How DDT metabolite disrupts breast cancer cells
2. Antibacterial chemical disrupts hormone activities
3. Nicotine in breast milk disrupts infants sleep patterns
4. Occupational Therapy Month 2008 Highlights Profession as Career Choice
5. SEISMIC study issues glum report on cell therapy
6. 2-drug blood pressure therapy lowers cardiovascular risk
7. Positive results from Visudyne(R) combination therapy study reported at Annual Macula Society Conference
8. BioLife Solutions Expands Presence in Cell Therapy and Cord Blood Banking Market Segments
9. Ukiah Home Oxygen Therapy Patients and Physicians Meet with Congressman Mike Thompson to Share Benefits of Quality Home Oxygen Care
10. Drug Therapy Boosting Heart-Attack Survival Rates
11. ClearScript Offers Innovative Medication Therapy Management Program to Employee Health Plans
Post Your Comments:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... established the certification process to promote standards of excellence for the field of ... scheduled for March 22 – 25, 2018 in Orlando, Florida at the Omni ...
(Date:10/13/2017)... CT (PRWEB) , ... October 13, 2017 , ... ... long-term care services, staged a mock evacuation of the facility as part of a ... Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as ...
(Date:10/13/2017)... NJ (PRWEB) , ... October 13, 2017 , ... Global ... at scenic Alexandria Park in Milford, NJ. This free event, sponsored by Global ... physical activity. The fun run is geared towards children of all ages; it ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains ... possible to save lost souls in the Philippines. “The Journey: From the Mountains to ... dedicated teacher of the Bible. She has taught all ages and currently teaches a ...
(Date:10/12/2017)... ... 12, 2017 , ... Planet Fitness, one of the largest and fastest growing ... open a flagship location in Covington, LA at 401 N. U.S. Highway 190, in ... to Office Depot in the Holiday Square shopping center. Its location allows it to ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017  AllianceRx Walgreens Prime, the combined central specialty ... pharmacy benefit manager Prime Therapeutics LLC (Prime), today officially ... the unveiling of new signage at its headquarters in ... at a few other company-owned facilities across the country. ... some of whom will begin to see the AllianceRx ...
(Date:9/28/2017)... 28, 2017 Cohen Veterans Bioscience and Early ... of wearable and home sensors for real-time monitoring of ... Foundation, a nonprofit organization focused on disruptive health solutions ... affordable analytical system to record and integrate behavioral, cognitive, ... ...
(Date:9/25/2017)...  EpiVax, Inc., a leader in the fields ... announced the launch of EpiVax Oncology Inc., a ... cancer vaccines. EpiVax has provided $500,000 in seed ... technologies to the new precision immunotherapy venture. Gad ... as Chief Executive Officer. Gad brings over 25 ...
Breaking Medicine Technology: