Navigation Links
Parental exposure to THC Linked to drug addiction, compulsive behavior in unexposed offspring
Date:1/22/2014

New York, NY Jan. 16, 2014 Exposing adolescent rats to THC (tetrahydrocannabinol) the primary psychoactive ingredient in marijuanacan lead to molecular and behavioral alterations in the next generation of offspring, even though progeny were not directly exposed to the drug, researchers at the Icahn School of Medicine at Mount Sinai have found. Male offspring showed stronger motivation to self-administer heroin during their adulthood and molecular changes in the glutamatergic system, which is the most important excitatory pathway for neurotransmission in the brain. Damage in the glutamate pathway, which regulates synaptic plasticity, has been linked to disturbances in goal-directed behavior and habit formation.

The study is published online Jan. 22 in Neuropsychopharmacology.

"Our study emphasizes that cannabis [marijuana] affects not just those exposed, but has adverse affects on future generations," said Yasmin Hurd, PhD, the study's senior author, and professor of psychiatry and neuroscience at the Icahn School of Medicine at Mount Sinai. "Finding increased vulnerability to drug addiction and compulsive behavior in generations not directly exposed is an important consideration for legislators considering legalizing marijuana."

In the study, Dr. Hurd and colleagues gave adolescent male rats 1.5 mg/kg of THC, similar to about one joint in human use. None of the rats had been exposed to THC before, but their parents were exposed to THC as teens and then mated later in life. THC-exposed offspring worked harder to self-administer heroin by pressing a lever multiple times to get heroin infusion.

Although marijuana use and safety tends to be discussed in terms of its impact to the individual during the lifetime, few studies have addressed adverse effects in future generations. "What this opens up are many questions regarding the epigenetic mechanisms that mediate cross-generational brain effects," said Dr. Hurd.

Future studies are now being explored to determine whether THC effects continue to be transmitted to even the subsequent grandchildren and great-grandchildren generations. Another important question relates to potential treatment interventions in order to reverse the cross-generational THC effects. Such insights could also have implications for novel treatment opportunities for related psychiatric illnesses.


'/>"/>

Contact: NewsMedia
sid.dinsay@mountsinai.org
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Related medicine news :

1. Study finds parental stress linked to obesity in children
2. Parental monitoring lowers odds of a gambling problem
3. Parental perceptions are preventing HPV vaccination success
4. Abuse, lack of parental warmth in childhood linked to multiple health risks in adulthood
5. Ethical quandary about vaccinations sparked by tension between parental rights and protecting public health
6. New BUSM study explores providers perceptions of parental concerns about HPV vaccination
7. Parental addictions linked to adult childrens depression
8. Pre-College Parental Chat May Reduce Freshman Drinking
9. Diet, parental behavior, and preschool can boost childrens IQ
10. Trickle-down anxiety: Study examines parental behaviors that create anxious children
11. Review: Altruisms influence on parental decision to vaccinate children is unclear
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/24/2016)... Los Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... plastic surgery procedures that most people are unfamiliar with. The article goes on to ... known procedures, but also many of these less common operations such as calf and ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... ... 2016 , ... EB Medicine presented its first-ever “Issue of ... in Ponte Vedra Beach, FL. The awards honor the outstanding work of leading ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the efforts ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the ... (United States, China, Japan, Brazil, United Kingdom, Germany, France, ... Surgical Procedure Volumes: ... provides surgical procedure volume data in a geographic context. ... analysis of growth drivers and inhibitors, including world population ...
(Date:6/23/2016)... The Biotechnology industry might still ... great opportunities to investors. Stock-Callers.com assesses the recent performances ... XON ), Vertex Pharmaceuticals Inc. (NASDAQ: ... ARNA ), and Regeneron Pharmaceuticals Inc. (NASDAQ: ... your complimentary trade alerts at: http://stock-callers.com/registration ...
(Date:6/23/2016)... SAN DIEGO , June 23, 2016 /PRNewswire/ ... advancing programs that address medical conditions resulting from ... that it has appointed Greg Doyle ... member of Leading BioSciences, executive management team and ... officer and chief financial officer. He will provide ...
Breaking Medicine Technology: