Navigation Links
Parallels between cancers, infection suppression reported
Date:1/3/2011

Tiny parasitoid wasps can play an important role in controlling the populations of other insect species by laying their eggs inside the larvae of these species. A newly hatched wasp gradually eats the host alive and takes over its body.

The host insect is far from defenseless, however. In Drosophila (fruit flies), larvae activate humoral immunity in the fat body and mount a robust cellular response that encapsulates and chokes off the wasp egg.

New research by Dr. Shubha Govind, professor of biology at The City College of New York, and colleagues reveals parallels between how this mechanism fights the wasp infection and the way blood cancer develops. "There are fundamental similarities in the processes," she explains. "The response to wasp infection is similar to acute inflammation while the cancer is akin to chronic inflammation in mammals, where regulation of the response to an infection also goes out of control."

Professor Govind reports that the immune system that counters wasp egg infection is highly restrained. The system works like a thermostat, with certain proteins detecting the infection and triggering the immune reactions. Once the egg has been destroyed the immune reactions come to a halt.

However, when the regulating mechanism goes haywire, cancer can develop. Through sumoylation, the correct balance between positive and negative factors is achieved, Professor Govind and colleagues report.

"There is strong evidence that the fundamental mechanism of regulation uncovered in flies also works in humans," she notes. "Because of the molecular similarities between flies and mammals, it may be possible to use flies to test drugs for potential anti-inflammatory effects in human disease." While such drugs would not cure cancer, they could control inflammation and, perhaps, delay cancer progression.

Other potential applications are in pest control for agriculture. Instead of using insecticides, parasitoids with the ability to suppress the hosts' immune systems could be used to kill insect pests. Also, insecticides could be developed that, at very low concentrations, would weaken the immune systems of host insects and enable parasitoid eggs to succeed, Professor Govind adds.


'/>"/>

Contact: Ellis Simon
esimon@ccny.cuny.edu
212-650-6460
City College of New York
Source:Eurekalert

Related medicine news :

1. Parallels Launches Parallels Server for Mac Bare Metal Edition
2. Winners are Grinners at the Inaugural Parallels Partner Awards
3. Researchers Find Links Between Sleep, Anesthesia and Coma
4. Link between depression and inflammatory response found in mice
5. Playing by the rules? New book examines relationship between law and sport
6. AGA, General Mills announce grant to uncover role between intestinal bacteria and health and disease
7. New trial studies link between stroke and atrial fibrillation
8. Tests between colonoscopies could be lifesaver for high-risk patients
9. Low-dose aspirin reduces death rates from range of cancers by between 20 and 30 percent
10. Study Suggests Link Between Crohns Disease and PTSD
11. No Link Between Heartburn Drugs and Birth Defects: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... 2016 , ... Stephanie Hebert Insurance Agency, serving families of ... charity campaign. As part of their ongoing community involvement program, funds are now ... children deserve a voice, and in the spirit of neighbors helping neighbors in ...
(Date:2/8/2016)... ... 2016 , ... Brenton Engineering , powered by Pro ... wrapped products at WestPack 2015, February 9-11, in Anaheim, California. This new solution ... or fully-automatic case packing with a small footprint, rugged, highly flexible, and cost-effective ...
(Date:2/8/2016)... Hilton Head Island, SC (PRWEB) , ... February 08, 2016 , ... ... Head and surrounding areas with a vital new community enrichment program, has teamed up ... to local women and children suffering from intimate abuse. To support all those victimized ...
(Date:2/8/2016)... ... , ... Delta Dental of California and its affiliated companies announced today that ... who recently retired as president and CEO of Delta Dental of California and its ... Year , helped lead the effort to raise funds for studies to strengthen pancreatic ...
(Date:2/8/2016)... ... February 08, 2016 , ... Eating disorders ... significant number of women and men with eating disorders report a history of ... predicts the development of an eating disorder. , At the 2016 iaedp ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 8, 2016 /PRNewswire/--  Cell Applications, Inc. and ... services are now available in North ... (3D) bioprinting approach called the "Kenzan Method." Utilizing ... a state-of-the-art robotic system that fabricates 3D tissue ... pay-for-service bio-printing model that makes scaffold-free tissue available ...
(Date:2/8/2016)... Feb. 8, 2016 ... of the "Label-Free Detection Market by ... 2020" report to their offering. ... addition of the "Label-Free Detection Market ... to 2020" report to their offering. ...
(Date:2/8/2016)... , Feb. 8, 2016  Astellas Pharma Inc. President and ... promotion of James Robinson as president, Americas Operations, ... in North and South America , effective ... US, representing the commercial organization in the United ... Masao Yoshida , who is retiring in ...
Breaking Medicine Technology: