Navigation Links
Paradoxical Alzheimer's finding may shed new light on memory loss
Date:3/12/2008

March 8, 2008 Do you remember the seventh song that played on your radio on the way to work yesterday? Most of us dont, thanks to a normal forgetting process that is constantly cleaning house culling inconsequential information from our brains. Researchers at the Buck Institute now believe that this normal memory loss is hyper-activated in Alzheimers disease (AD) and that this effect is key to the profound memory loss associated with the incurable neurodegenerative disorder.

Last year, this same group of researchers found that they could completely prevent Alzheimers disease in mice genetically engineered with a human Alzheimers geneMouzheimersby blocking a single site of cleavage of one molecule, called APP for amyloid precursor protein. Normally, this site on APP is attacked by molecular scissors called caspases, but blocking that process prevented the disease. Now they have studied human brain tissue and found that, just as expected, patients suffering from AD clearly show more of this cleavage process than people of the same age who do not have the disease. However, when they extended their studies to much younger people without Alzheimers disease, they were astonished to find an apparent paradox: these younger people displayed as much as ten times the amount of the same cleavage event as the AD patients. The researchers now believe they know why.

The Buck Institute study implicates a biochemical switch associated with that cleavage of APP, causing AD brains to become stuck in the process of breaking memories, and points to AD as a syndrome affecting the plasticity or malleability of the brain. The study, due to be published in the March 7 issue of the Journal of Alzheimers Disease, provides new insight into a molecular event resulting in decreased brain plasticity, a central feature of AD.

Young brains operate like Ferraris shifting between forward and reverse, making and breaking memories with a facility that surpasses that of older brains, which are less plastic, said Dale Bredesen, MD, Buck Institute faculty member and leader of the research group. We believe that in aging brains, AD occurs when the molecular shifting switch gets stuck in the reverse position, throwing the balance of making and breaking memories seriously off kilter.

In previous research, lead author Veronica Galvan, PhD, prevented this cleavage in mice genetically engineered to develop the amyloid plaques and deposits associated with AD. These surprising mice had normal memories and showed no signs of brain shrinkage or nerve cell damage, despite the fact that their brains were loaded with the sticky A-beta plaques that are otherwise associated with Alzheimers disease.

A-beta is produced throughout the brain throughout life; we believe that it is a normal regulator of the synapses, the connections between neurons, said Galvan, who added that AD, like cancer, is a disease in which imbalanced cell signaling plays an important role.

The fact that many people develop A-beta plaques yet show no symptoms of AD tells us that the downstream signaling of A-betanot just A-beta itselfis critical, said Bredesen, and these pathways can be targeted therapeutically. Simply put, we can restore the balance. Continuing research at the Buck Institute focuses on nerve signaling and efforts to disconnect the molecular mechanism that throws memory-making in the reverse direction, as well as understanding mechanisms that support brain cell connections that are crucial to the process of memory making.


'/>"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
IOS Press
Source:Eurekalert

Related medicine news :

1. Alzheimers Research Target May Be a Dead End
2. MHA to Release Findings of Independent Long Term Care Member Study
3. New findings about the brain lead to treatment for eating disturbances
4. New Findings Support Alternatives to Pap Test
5. DNA Findings Reveal Genetic History of Humans
6. New findings on emerging contaminants
7. Research findings may lead to new ways to study and fight diabetes
8. A Sneak Peek Into the Special Needs Home of Tomorrow - Renowned Autism Consultant Valerie Herskowitz to Present Latest Findings at Autism Through the Lifespan Conference February 14-17 in Orlando
9. New findings contradict a prevailing belief about the inner ear
10. NeoStrata Clinical Findings Reveal Benefits of Combining Glycolic Acid Peels and Targeted Home Care With Microdermabrasion for Optimized Treatment of Photodamaged Skin
11. New finding may help explain development of preeclampsia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... As a ... Magna Cum Laude and his M.D from the David Geffen School of Medicine at ... returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions ... initiated cultivation and processing operations at its production facility, and opened its first ... is the manufacturer of a complete system of proactive air and surface purification ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated testing ... With this clearance, Roche is the first IVD company ... for sepsis risk assessment and management. PCT ... PCT levels in blood can aid clinicians in assessing ...
(Date:6/23/2016)... , , , WHEN: ... , , , , LOCATION: , , , Online, with ... , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice ... Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... industry is witnessing an exceptional era. Several new demand spaces, such ...
(Date:6/23/2016)... -- The vast majority of dialysis patients currently receive ... usually 3 times a week, with treatment times averaging ... equipment preparation and wait time.  This regimen can be ... who are elderly and frail.  Many elderly dialysis patients ... for some duration of time. Residents in ...
Breaking Medicine Technology: