Navigation Links
Paradoxical Alzheimer's finding may shed new light on memory loss
Date:3/12/2008

March 8, 2008 Do you remember the seventh song that played on your radio on the way to work yesterday? Most of us dont, thanks to a normal forgetting process that is constantly cleaning house culling inconsequential information from our brains. Researchers at the Buck Institute now believe that this normal memory loss is hyper-activated in Alzheimers disease (AD) and that this effect is key to the profound memory loss associated with the incurable neurodegenerative disorder.

Last year, this same group of researchers found that they could completely prevent Alzheimers disease in mice genetically engineered with a human Alzheimers geneMouzheimersby blocking a single site of cleavage of one molecule, called APP for amyloid precursor protein. Normally, this site on APP is attacked by molecular scissors called caspases, but blocking that process prevented the disease. Now they have studied human brain tissue and found that, just as expected, patients suffering from AD clearly show more of this cleavage process than people of the same age who do not have the disease. However, when they extended their studies to much younger people without Alzheimers disease, they were astonished to find an apparent paradox: these younger people displayed as much as ten times the amount of the same cleavage event as the AD patients. The researchers now believe they know why.

The Buck Institute study implicates a biochemical switch associated with that cleavage of APP, causing AD brains to become stuck in the process of breaking memories, and points to AD as a syndrome affecting the plasticity or malleability of the brain. The study, due to be published in the March 7 issue of the Journal of Alzheimers Disease, provides new insight into a molecular event resulting in decreased brain plasticity, a central feature of AD.

Young brains operate like Ferraris shifting between forward and reverse, making and breaking memories with a facility that surpasses that
'/>"/>

Contact: Kris Rebillot
krebillot@buckinstitute.org
415-209-2080
IOS Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Alzheimers Research Target May Be a Dead End
2. MHA to Release Findings of Independent Long Term Care Member Study
3. New findings about the brain lead to treatment for eating disturbances
4. New Findings Support Alternatives to Pap Test
5. DNA Findings Reveal Genetic History of Humans
6. New findings on emerging contaminants
7. Research findings may lead to new ways to study and fight diabetes
8. A Sneak Peek Into the Special Needs Home of Tomorrow - Renowned Autism Consultant Valerie Herskowitz to Present Latest Findings at Autism Through the Lifespan Conference February 14-17 in Orlando
9. New findings contradict a prevailing belief about the inner ear
10. NeoStrata Clinical Findings Reveal Benefits of Combining Glycolic Acid Peels and Targeted Home Care With Microdermabrasion for Optimized Treatment of Photodamaged Skin
11. New finding may help explain development of preeclampsia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... TX (PRWEB) December 26, 2014 This ... state of the global Sterilizers industry with a focus ... on the market status of the Sterilizers manufacturers and ... companies and individuals interested in the industry. This report ... definition, applications and manufacturing technology. In this part, the ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Product liability ... ASR hip recall ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move ... to an Order issued in the U.S. District Court, ... will convene an open conference on January 7, 2015, ... States Courthouse in West Palm Beach, Florida. The Conference ...
(Date:12/25/2014)... The short film “Color of Honor” by ... of a true 9/11 hero, Welles Remy Crowther. It has ... 24 hours of Nuremberg International Short Film Festival and the ... Actress, screenwriter and director Luciana Lagana plays the mother ... her husband, Gregory Graham - Graham plays a ...
(Date:12/25/2014)... When head lice hits a home or school, ... get rid of it while keeping it from taking over ... have the solution right in their neighborhood: Lice Troopers ... provides full spectrum head lice screening and treatment services to ... Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. ...
(Date:12/25/2014)... common during the holidays, but there are strategies that can ... arrive at a party hungry. It may seem logical to ... party, but deprivation leads to hunger, and hunger leads to ... Mount Kisco, N.Y., said in a hospital news release. ... to have a snack before attending a party when you ...
Breaking Medicine News(10 mins):Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2
... travel warnings for Hong Kong and China's Guangdong province, ... virus emerged. It is believed the epidemic originated in ... the outbreak in those areas. Hong Kong Chief Executive ... the efforts of medical staff, but highlighting the need ...
... for both migraine and major depression may benefit patients ... with migraine or severe headaches aged between 25 and ... that the risk of migraine in individuals with pre-existing ... with no history of major depression.// Moreover the risk ...
... developed to treat the common cold could help fight against ... drug might not be available to the general public immediately. ... common cold. As SARS and common cold are caused by ... drug, AG-7088, with a little molecular tinkering, could be effective ...
... at Melbourne on skin cancer could save thousands of lives. ... per cent of melanoma cancers but caused up to 70 ... research shows the pimple-like melanoma is the most dangerous. However ... can cause a nodular melanoma. It appears anywhere on the ...
... study made by Heart and Stroke Foundation it was found ... by heart disease. About 30% of people in their 20s ... and 29 years. About 80 per cent of adult Canadians ... disease, and about 10 per cent have three risk factors ...
... governments are finding themselves in a tight corner with finances ... seek for further Medicaid cuts. The physician across the country ... for patient care. To add to the woes the ... the Medicaid program, and this also includes evicting half a ...
Cached Medicine News:
(Date:12/24/2014)... N.C. , Dec. 23, 2014  Medical Science ... As the key link between the medical device industry ... even more in the coming years as the device ... According to research by benchmarking firm, Best ... can gain an important edge is by harnessing new ...
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... "US Self-monitoring Blood Glucose Market" report to ... This market insight focuses on the developments ... the United States . Reimbursement analysis and the ... analyses for more than 73 SMBG meters have been ...
(Date:12/22/2014)... Dec. 22, 2014 Cyberonics, Inc. (NASDAQ: ... treatment and management of epilepsy, today announced it will participate ... on Wednesday, January 14, 2015, in San Francisco ... and Chief Executive Officer, will speak at 11:00 AM Pacific ... accessed by clicking on the Investor Relations link on the ...
Breaking Medicine Technology:Role of Medical Science Liaisons Evolving in Medical Device Sector 2US Self-monitoring Blood Glucose Market 2
... HARBIN, China, Sept. 27, 2011 /PRNewswire-Asia/ -- China ... ) ("China Botanic" or the "Company"), a developer, ... traditional Chinese medicines ("TCM") in China, today announced ... the National Marine and Terrestrial Symposium on Research ...
... 2011 A rapidly changing -- and highly competitive -- ... and ready to adapt new technologies and new therapeutic approaches ... successful market entry, Diabetes launch teams are scrutinizing their strategies ... a critical launch factor. According to primary ...
Cached Medicine Technology:China Botanic Hosts Symposium on Research of Polysaccharide Peptide and Natural Innovative Drugs 2China Botanic Hosts Symposium on Research of Polysaccharide Peptide and Natural Innovative Drugs 3To Succeed in Crowded Market, Diabetes Manufacturers Beginning Key Launch Tactics Earlier, Study Says 2
... Shandon Hyperclean 20 fume containment system ... with a swing-down front panel hinges ... the front opening. The sides ... acrylic which is impervious to most ...
... test delivers excellent sensitivity and specificity for ... simple, easy-to-use test that provides results in ... and ease-of-use enables you to deliver improved ... diagnosing and treating patients with pharyngitis. The ...
... The FLU OIA A/B test combines performance equivalence ... of Influenza A or B with a simple, ... minutes. The test has all the same procedural ... test will enable you decrease costs for unnecessary ...
... The Acceava Mononucleosis test provides superior ... with a simple procedure that provides ... evaluations with competitive products will convince ... attributes enable you to deliver improved ...
Medicine Products: