Paradigm shift: Switch for programmed cell death promotes spread of gl...(ugh the network of interwoven protein fi...),Health

Date:3/11/2008

ugh the network of interwoven protein fibers that separate different tissue layers of the body from each other. With the aid of these protein scissors, tumor cells invade healthy tissue and form the dangerous protrusions that penetrate deep into the brain tissue.

The result showed the scientists a way how to stop the invasion of glioblastoma: They treated mice that had been transplanted glioblastoma with an antibody that blocks CD95. As a result, the migration of cancer cells ceded.

This is almost a paradigm shift, says Ana Martin-Villalba. Up to now, the goal has been to promote formation of CD95 and CD95L in tumor cells. In the case of glioblastoma, we now have to warn against this approach: This would only additionally support the spread of the tumor. The goal is rather to block activation of CD95. However, it is currently not possible to investigate this treatment approach in humans, because a useable antibody against human CD95 protein is not yet available.

'/>"/>

Contact: Dr. Sibylle Kohlstdt s.kohlstaedt@dkfz.de Helmholtz Association of German Research Centres Source:Eurekalert

0 GOOD

Page: 1 2
Related medicine news :

1. Paradigm Selects Jopari to Provide E-Billing Gateway for Customers
2. Schizophrenia Gene May Have On/Off Switch
3. Brain Switch Helps Doctors Deal With Patients Pain
4. Switching to MA Coverage Unlikely for Current Beneficiaries With MediGap or Medicare Only
5. Scientists Spot Eye Development Switch
6. A molecular switch is linked to a common breast cancer
7. Researchers identify unusual molecular switch for common form of advanced breast cancer
8. Cell Structure Helps Direct Cancer Gene Switch
9. Childrens Hospital researchers identify molecular switch that could save very young lives
10. Protein-dependent switch regulates intracellular trafficking in epithelial cells
11. Switch for Internal Body Clock Found