Navigation Links
Paradigm shift: Switch for programmed cell death promotes spread of glioblastoma
Date:3/11/2008

This release is available in German.

Malignant tumors have usually lost their ability to destroy themselves by programmed cell death, or apoptosis. Therefore, tumors are often resistant to chemotherapy or radiation therapy, whose effect is based on forcing tumor cells to commit suicide.

This resistance to apoptosis is caused by defects in one of the numerous molecular switches regulating the self-destruction process. This is why scientists have been trying for a long time to restore the formation of these switches in cancer cells and, thereby, to restore their apoptotic ability. Among the key molecular switches is cell surface protein CD95, which is activated by the binding of its partner, CD95L. This triggers a whole cascade of biochemical signals leading to the death of the cell.

At the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Dr. Ana Martin-Villalba and her team have been studying the function of CD95 on glioblastoma cells. Glioblastoma is an extremely aggressive malignant brain tumor that resists all treatments. The cancer grows like a coral and invades surrounding brain tissue with very fine protrusions. Individual, isolated tumor cells can penetrate even further. Thus, surgeons have no chance to completely remove the tumor tissue. In addition, glioblastoma is highly resistant to both chemotherapy and radiotherapy.

Martin-Villalbas team found large amounts of CD95 on glioblastoma cells, while CD95L was localized primarily at the so-called invasive front the border between tumor tissue and healthy brain tissue. Despite the presence of both molecules, the cells are resistant to programmed cell death. But this is not all: If CD95 on the surface of glioblastoma cells is activated by CD95L, this leads to the production of a protein called MMP9, which is known to be a molecular scissors. MMP9 cuts thro
'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Paradigm Selects Jopari to Provide E-Billing Gateway for Customers
2. Schizophrenia Gene May Have On/Off Switch
3. Brain Switch Helps Doctors Deal With Patients Pain
4. Switching to MA Coverage Unlikely for Current Beneficiaries With MediGap or Medicare Only
5. Scientists Spot Eye Development Switch
6. A molecular switch is linked to a common breast cancer
7. Researchers identify unusual molecular switch for common form of advanced breast cancer
8. Cell Structure Helps Direct Cancer Gene Switch
9. Childrens Hospital researchers identify molecular switch that could save very young lives
10. Protein-dependent switch regulates intracellular trafficking in epithelial cells
11. Switch for Internal Body Clock Found
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... May 23, 2013 Sika Sarnafil ... waterproofing membranes, today announced Imperial Roof Systems of Iowa ... professionalism and dedication to quality during the re-roofing of ... Systems is a Sika Sarnafil Elite contractor and one ... Roof Systems is committed to sustainable building practices and ...
(Date:5/23/2013)... Washington, DC (PRWEB) May 23, 2013 ... by JD Media Surge, LLC. Targeting members of the ... services online and attract new patients, the consulting service ... Internet marketing strategies. , The medical Internet marketing agency ... struggling to get results online. As part of the ...
(Date:5/23/2013)... Retül University , the market leader ... formation of a strategic educational partnership with Ero ... a bike industry first “Positioned for Speed” course combining ... trial, road and triathlon bike fit. , This course ... with a Retül University, F.I.S.T. or S.I.C.I fit certification. ...
(Date:5/23/2013)... Rapids, IA (PRWEB) May 23, 2013 Diversity ... Creative Corridor have an expanded understanding of diversity. The ... The survey was done from February-March of this year. 1198 ... survey as a follow up to its benchmark survey in ... top factors reported in the definition of diversity were race ...
(Date:5/23/2013)... By Dennis Thompson HealthDay Reporter , , THURSDAY, ... taken by millions to lower their cholesterol, but the ... their cardiovascular health through exercise, researchers say. A ... to make any significant fitness gains while taking a ... not on the drug but undergoing the same exercise ...
Breaking Medicine News(10 mins):Health News:Sika Sarnafil Announces Recycling Project of the Year Winner 2Health News:Healthcare Internet Marketing Consulting Services Launched by JD Media Surge 2Health News:Retül, Ero Sports and Alphamantis Partner for Industry First Aero Fit Course 2Health News:Retül, Ero Sports and Alphamantis Partner for Industry First Aero Fit Course 3Health News:Diversity Focus Announces Results from the 2013 Creative Corridor Community Survey 2Health News:Statins May Hamper Workout Results 2Health News:Statins May Hamper Workout Results 3
... , , WASHINGTON, Aug. 24 In response ... and Cardiovascular H ealth: A Scienti f ic State m ... journal Circulat i on, Dr. Maureen Storey, senior vice ... for t h e America n Beverage A ...
... , Proposed Medicare Cuts Will Harm Seniors, Care, Place ... Jeopardy , , Study Finds California Seniors Hit ... Calif., Aug. 24 A new American Health Care Association analysis of ... recently-enacted Medicare regulation cutting Medicare-funded nursing home care by $12 billion over ...
... RESEARCH TRIANGLE PARK, N.C., Aug. 24 GlaxoSmithKline ... of Advair Diskus(R) (fluticasone propionate and salmeterol inhalation powder) medication ... near Richmond, Virginia. Medicine in the stolen cartons could ... the legitimate supply chain and the storage conditions under which ...
... , NASHVILLE, Tenn., Aug. 24 Cumberland ... it will report second quarter 2009 financial results before the market ... live Internet webcast will be held on Thursday, August 27, 2009 ... , To participate on the call, please dial 877-604-9672 ...
... , , , - ... flawed document he says "pushes pulling the plug." , ... of the national non-profit organization Aging with Dignity, today called on ... "Your Life, Your Choices" advance care planning guide dubbed "The Death ...
... down the disease, study says , MONDAY, Aug. 24 ... very early stages of Alzheimer,s disease might become hyperactive ... , Researchers from the Cleveland Clinic tested 69 mentally ... Alzheimer,s disease because of family history or genetic markers. ...
Cached Medicine News:Health News:American Beverage Association Response to American Heart Association Statement on Added Sugars 2Health News:New Study of House Health Reform Bill: California Faces Over $3.7 Billion in Medicare-Funded Nursing Home Cuts Over Ten Years 2Health News:GSK Advisory: Warehouse Theft 2Health News:Cumberland Pharmaceuticals to Announce Second Quarter 2009 Financial Results on August 27, 2009 2Health News:Veterans Administration Must Suspend Use of So-Called 'Death Book' on Veterans, Malley Says 2Health News:MRI Might Find Early Alzheimer's 2
(Date:5/23/2013)... ANN ARBOR, Mich. , May 23, 2013  Every ... crucial flow of air to his lungs. April ... somehow the dire predictions weren,t true. "Quite a ... leaving the hospital alive," says April Gionfriddo ... we were desperate. Anything that would work, we would take ...
(Date:5/23/2013)... , May 23, 2013  Texas, premier physician ... deliver doctors the survival tools they need to provide ... in today,s health care marketplace. "I am ... save local practices," said Stephen L. Brotherton ... (TMA). " Texas doctors are determined ...
(Date:5/23/2013)... , May 23, 2013  Hologic, Inc. (Hologic ... a leading developer, manufacturer and supplier of premium ... an emphasis on serving the healthcare needs of ... study in a U.S. clinical practice comparing breast ... tomosynthesis) with conventional 2D mammography alone showed a ...
Breaking Medicine Technology:Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 2Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 3Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 4TMA Launches Physician Services Organization for Patient Care 2TMA Launches Physician Services Organization for Patient Care 3TMA Launches Physician Services Organization for Patient Care 4First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 2First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 3First Large-Scale Population-Based Study in the U.S. Shows Hologic's 3D Mammography (Breast Tomosynthesis) Significantly Reduces Recall Rates While Simultaneously Improving Cancer Detection 4
... office of Nurenberg, Paris, Heller & McCarthy has ... Johnson,s artificial joint replacement company DePuy Orthopaedics, Inc., ... from the company,s now-recalled hip replacement device.  (Case ... Ohio, Eastern Division) "Revision" Surgeries ...
... NEW YORK, Oct. 11 Access Pharmaceuticals, Inc. ... biopharmaceutical company specializing in products for cancer and supportive ... European clinical experience of MuGard at this year,s European ... of the findings reported in the ESMO presentation included: ...
Cached Medicine Technology:DePuy Orthopaedics Accused of Deceiving Hip Replacement Patients 2DePuy Orthopaedics Accused of Deceiving Hip Replacement Patients 3MuGard Provides Significant Improvement or Stabilization of Oral Mucositis in Over 75% of Patients in European Clinical Experience 2MuGard Provides Significant Improvement or Stabilization of Oral Mucositis in Over 75% of Patients in European Clinical Experience 3MuGard Provides Significant Improvement or Stabilization of Oral Mucositis in Over 75% of Patients in European Clinical Experience 4
... the Marco Keratometer I and ... instruments for objectively measuring corneal ... the added feature of internal ... or those who prefer to ...
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
... Bulb Direct has been selling ... since 1996, and we are ... satisfaction guarantee. Check out our ... see our discount light bulbs ...
... been selling replacement bulbs on ... we are extremely proud of ... out our catalog of replacement ... light bulbs specials. ,Check ...
Medicine Products: