Navigation Links
Pap Test Could Spot Some Ovarian Cancers, Study Finds
Date:1/9/2013

By Maureen Salamon
HealthDay Reporter

WEDNESDAY, Jan. 9 (HealthDay News) -- With no routine screening test currently available for uterine or ovarian cancer -- the latter of which is extremely lethal -- scientists have found promise in a new method that can detect both types using cervical fluid obtained during routine Pap tests.

A pilot study led by researchers at Johns Hopkins University's Kimmel Cancer Center, in Baltimore, reports that DNA analysis of cervical fluid detected 100 percent of uterine cancers and 41 percent of ovarian cancers in a small group of women, with no false-positive results.

"This initial proof-of-concept pilot study really laid the groundwork to move forward," said study author Dr. Luis Diaz, an associate professor of oncology. "So many [disease indicator] tests out there lead to ambiguous results, which lead to a lot of anxiety in patients and unnecessary diagnostic tests and costs. I think this test offers the possibility of not only being an effective cancer screening test, but also one we can do without increasing the cost of health care."

The study is published Jan. 9 in the journal Science Translational Medicine.

Since Pap tests were introduced in the 1940s, the incidence and death rate from cervical cancer -- the leading cause of cancer deaths among women a century ago -- have plummeted 75 percent, according to study background information. But deaths from ovarian and uterine cancers did not drop substantially in the same time period. More than 69,000 American women were diagnosed with these two gynecological cancers in 2012, with 15,000 expected to die of ovarian cancer and 8,000 of uterine (also called endometrial) cancer each year.

The new research relied on the so-called PapGene test, which sequences the genes of cancer-specific mutations involved in ovarian and endometrial cancers. "Simple anatomy" explains why cervical fluid may contain more cells shed from the uterus instead of the ovaries, Diaz said, because ovaries are located farther up the reproductive tract and cells must first pass through the fallopian tubes.

Diaz and his colleagues applied the PapGene test to samples from ovarian and endometrial cancers of about 20 women with each type at Johns Hopkins and three other institutions, detecting both early and late-stage disease in both cancers tested.

The test -- which is years away from being available clinically -- would cost less than $100 and perhaps substantially less in several years after more research has been completed, Diaz said, adding that he'd like follow-up studies to include hundreds of women.

Another expert said the findings are "exciting" and indicate that the test has potential.

"Ovarian cancer is really the cancer we have no way of screening for, and no early symptoms, so anything we can do to allow us to pick it up early is very exciting," said Dr. Diana Contreras, director of gynecologic oncology at Long Island Jewish Medical Center in New Hyde Park, N.Y. "And certainly a test that can be done easily and cheaply is very exciting."

Abnormal bleeding in postmenopausal women is one way uterine cancer can be detected before reaching advanced stages. But ovarian cancer typically presents with vague symptoms easily mistaken for other conditions, making early detection extremely difficult.

Therefore, even a screening test detecting ovarian cancer 40 percent of the time it's present -- especially with no false-positive results -- is superior to what's available, Diaz and Contreras said.

"I think this study says the test has potential," Contreras said. "We must move forward with finding an answer, because ovarian cancer is so deadly."

More information

The U.S. Department of Health and Human Services offers a Pap test fact sheet .

SOURCES: Luis Diaz, M.D., associate professor, oncology, Johns Hopkins Kimmel Cancer Center, Baltimore; Diana Contreras, M.D., director, gynecologic oncology, Long Island Jewish Medical Center, New Hyde Park, N.Y.; Jan. 9, 2013, Science Translational Medicine


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Red wine, fruit compound could help block fat cell formation
2. Pulse pressure elevation could presage cerebrovascular disease in Alzheimers patients
3. Report says new evidence could tip the balance in aspirin cancer prevention care
4. Climate Change Could Be Tough on Seniors Health: Study
5. Could Menthol Cigarettes Pose Even Higher Stroke Risk?
6. Online Tool Could Diagnose Autism Quickly, Developers Say
7. Codeine After Surgery Could Endanger Certain Kids: Study
8. BMC study shows diverting passengers to elevators could help reduce falls at Logan Airport
9. Discovery could help to develop drugs for organ transplant and cancer patients
10. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
11. Saliva test could dramatically increase detection of oral cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pap Test Could Spot Some Ovarian Cancers, Study Finds
(Date:6/26/2016)... (PRWEB) , ... June 27, 2016 , ... Quality metrics ... yet in many ways they remain in the eye of the beholder, according to ... a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
Breaking Medicine Technology: