Navigation Links
Panel of serum biomarkers may reduce number of lung biopsies needed
Date:3/15/2012

DENVER A panel of serum biomarkers could help predict the level of lung cancer risk in high-risk patients, offering doctors an option before proceeding with a biopsy. Research presented in the April 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology shows that a panel of 10 serum protein biomarkers could help in the lung cancer diagnosis. The biomarkers include: prolactin, transthyretin, thrombospondin-1, E-selectin, C-C motif chemokine 5, macrophage migration inhibitory factor, plasminogen activator inhibitor-1, receptor tyrosine-protein kinase erbB-2, Cyfra 21.1 and serum amyloid A. Further work is necessary to validate these exciting results.

In June, the National Lung Screening Trial showed that lung cancer deaths fell by 20 percent and all-cause mortality fell by 7 percent when heavy smokers were screened regularly using low-dose spiral computed tomography (CT) compared with standard chest x-ray. The problem is that often these screenings can present false positive results.

According to the study, "about 20 percent of the 1-2 cm nodules that are concerning enough to be considered for biopsy are actually malignant. Given the substantial risks of invasive diagnostic thoracic procedures, unselective biopsy of every person with a small nodule is clinically unacceptable."

The researchers conclude that these biomarkers have potential to aid in the early detection of lung cancer by adding to the information gathered by CT screening. The analysis was carried out from patients enrolled in the Pittsburgh Lung Screening Study, which is funded by the National Cancer Institute Specialized Program of Research Excellence (SPORE) in Lung Cancer.

The lead author of this work is Dr. William Bigbee and IASLC member co-authors include Dr. David Wilson, Dr. Jill Siegfried and Dr. Sanja Dacic.


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@IASLC.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1

Related medicine news :

1. Panel asks dairy avoiders: Are you getting enough?
2. Avoiding Dairy Due to Lactose Intolerance is Unnecessary in Most Cases and May Pose Diet and Health Risks, Concludes National Institutes of Health Consensus Development Conference Panel
3. All Global Launches Physician Panels in Russia and Poland
4. Panel questions VBAC bans, advocates expanded delivery options for women
5. Panel Finds Many Women Can Avoid Repeat C-Sections
6. Panel: Properly designed pay-for-performance models can support medical professionalism
7. Panel: FCCs Broadband Plan Will Boost Efforts to Expand Health IT
8. FDA Panel Weighs New Restrictions on Tanning Beds
9. R. Shane Jackson Selected as Panelist for Center for Health Transformation Member Meeting
10. Review Panel Leaves Controversial Lyme Disease Guidelines Unchanged
11. HIA-LI 22nd Annual Business Trade Show & Conference to Feature Healthcare Pavilion and Expert Panel Discussing Healthcare Economics and Politics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions today ... cultivation and processing operations at its production facility, and opened its first two ... the manufacturer of a complete system of proactive air and surface purification solutions ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 Jazz Pharmaceuticals plc (Nasdaq: ... Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ("HSR"), ... Inc. ("Celator"; Nasdaq: CPXX ) expired effective ... As previously announced on May 31, 2016, ... agreement under which Jazz Pharmaceuticals has commenced a tender ...
(Date:6/24/2016)... June 24, 2016  Consumers have taken a ... have placed more emphasis on patient outcomes. ... programs in the pharmaceutical industry have evolved beyond ... pharmaceutical companies are focusing on becoming more patient-oriented ... products and services that improve health. ...
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
Breaking Medicine Technology: