Navigation Links
Panel of melanoma mutations opens door to new treatment possibilities
Date:11/15/2011

SAN FRANCISCO Researchers have developed a new genetic screening tool that will aid in the investigation of possible treatments for patients with melanoma and the unique genetic mutations that may accompany the disease, according to data presented at the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, held Nov. 12-16, 2011.

Heinz-Herbert Fiebig, M.D., Ph.D., associate professor of medical oncology at the University of Freiburg in Germany, presented data from 25 patient-derived melanoma models for which he and his colleagues studied relevant genetic mutations and the effect of new targeted and cytotoxic chemotherapeutic agents.

In this study, Fiebig, who is also the president and CEO of Oncotest GmbH Institute for Experimental Oncology, and colleagues collected melanoma samples from 80 patients. They were able to grow 38 of them in nude mice from which 25 permanent models were established. Eight different genetic mutations were determined in these models.

"The most prominent mutations were found in the BRAF oncogene; namely, 16 out of 25 tumors were positive for the mutation," said Fiebig.

About 25 percent of melanoma cases had a mutated NRAS gene. PI3Kalpha mutations were rare, and the screening found no mutations of the KRAS gene, which is a common genetic mutation in other forms of cancer.

The researchers then exposed the melanomas bearing specific mutations in vitro in the clonogenic assay to a variety of cancer treatments including traditional cytotoxic chemotherapy drugs, such as cisplatin, paclitaxel or vincristine, and modern chemotherapeutic drugs that target specific mutations, such as sorafenib and vemurafenib. They hoped to determine which, if any, of these drugs had an effect on the cancer cells and whether that effect was related to the presence or lack of a mutation.

The tests indicated that vemurafenib or PLX-4720 was most effective in melanoma tumor sa
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Panel asks dairy avoiders: Are you getting enough?
2. Avoiding Dairy Due to Lactose Intolerance is Unnecessary in Most Cases and May Pose Diet and Health Risks, Concludes National Institutes of Health Consensus Development Conference Panel
3. All Global Launches Physician Panels in Russia and Poland
4. Panel questions VBAC bans, advocates expanded delivery options for women
5. Panel Finds Many Women Can Avoid Repeat C-Sections
6. Panel: Properly designed pay-for-performance models can support medical professionalism
7. Panel: FCCs Broadband Plan Will Boost Efforts to Expand Health IT
8. FDA Panel Weighs New Restrictions on Tanning Beds
9. R. Shane Jackson Selected as Panelist for Center for Health Transformation Member Meeting
10. Review Panel Leaves Controversial Lyme Disease Guidelines Unchanged
11. HIA-LI 22nd Annual Business Trade Show & Conference to Feature Healthcare Pavilion and Expert Panel Discussing Healthcare Economics and Politics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... -- A new study found no evidence to support ... blood pressure increases patients, risk of falls and broken ... can prevent strokes and other cardiovascular problems, but many ... may lead to low blood pressure, resulting in falls ... at about 3,100 patients, aged 40 to 79, with ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 Biocide ... bringing on Wrench Advisors as a consultant and ... international large accounts. , As Wrench Advisors explains ... can help your organization plan and execute programs ... global distribution channels. Our experience developing joint venture ...
(Date:8/20/2014)... CA (PRWEB) August 20, 2014 The ... that Munira Lokhandwala, DDS, FAGD of Starbrite Dental in ... the AGD 2014 Annual Meeting & Exhibits, which took ... Award is presented to dentists who seek to provide ... profession. To earn this prestigious honor, Dr. Lokhandwala completed ...
(Date:8/20/2014)... enough sleep may wake up to worse consequences than ... risk of being obese by age 21 was 20 ... hours of sleep a night, compared with their peers ... Disease Control and Prevention recommends nine to ten hours ... School of Public Health at Columbia University and the ...
(Date:8/20/2014)... Miami, FL (PRWEB) August 20, 2014 Ticket ... Colombia tickets in Miami, FL at the Sun Life Stadium ... their football rivalry this September when Brazil and Colombia meet at ... two of the top 10 teams in the world and will ... held in Brazil. The match will kick-off on Sept. 5 and ...
Breaking Medicine News(10 mins):Health News:Tight Blood Pressure Control Doesn't Raise Risk of Falls, Study Says 2Health News:Biocide Systems Announces Partnership with Wrench Advisors 2Health News:Fremont Dentist Receives Prestigious AGD Fellowship Award 2Health News:Teen sleeplessness piles on risk for obesity 2Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Match 2Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Slashes Colombia vs. Brazil Tickets at Sun Life Stadium in Miami for Sept. 5th Match 3
... cancer organizations from around the country, including the ... the Mayo Clinic, Dana Farber Cancer Institute and ... patient care, novel therapies through clinical trials and ... Key topics include chronic lymphocytic leukemia, the role ...
... Health groups, nurses meet with Johnson & Johnson to discuss ... 22 A peer-reviewed paper in the Journal of the Dermatology Nurses, ... baby shampoo may be causing increased rates of allergic contact dermatitis, an ... open sores. , , The paper states that ...
... MERRIAM, Kan., Sept. 22 Actors, musicians, and athletes have ... auctioned off to benefit Christina Applegate,s foundation Right Action ... 2, one of the largest single day fundraisers for breast cancer ... Multimedia News Release, go to: http://www.prnewswire.com/mnr/denimday/40202/ , ...
... , , ... System 95-bed, community hospital, in Wilmington, OH, announced it will use ... event tracking, monitoring and workflow management tool designed to support a ... The hospital selected Quantros, a leading provider of safety ...
... New federal law may help deter young smokers, health advocates ... who enjoy a hint of vanilla, berry or chocolate when ... snuffed out. A new federal law banning fruit- and candy-flavored ... of the Family Smoking Prevention and Tobacco Control Act, legislation ...
... , SAN MATEO, Calif., Sept. 22 ... social media to help support a cause or honor a loved one. ... with the interactivity of social media, allowing caregivers to share their caring ... , , (Logo: http://www.newscom.com/cgi-bin/prnh/20070921/AQF020LOGO ) , , ...
Cached Medicine News:Health News:New Concerns Raised About Chemical in Leading Baby Shampoo 2Health News:Video: Celebrities Join Christina Applegate to Share Their Heart for Breast Cancer Awareness 2Health News:Video: Celebrities Join Christina Applegate to Share Their Heart for Breast Cancer Awareness 3Health News:Video: Celebrities Join Christina Applegate to Share Their Heart for Breast Cancer Awareness 4Health News:CMH Regional Health System Adopts Quantros for Event Management and Reporting 2Health News:Flavored Cigarette Ban Takes Effect 2Health News:Flavored Cigarette Ban Takes Effect 3Health News:Caring Candles Embrace Caregivers and Help Spread the Light 2
(Date:8/20/2014)... NEW YORK , Aug. 20, ... a new market research report is ... The Market for Hospital-Acquired Infection Control ... http://www.reportlinker.com/p01618925/The-Market-for-Hospital-Acquired-Infection-Control-Sterilization-Disinfection-Testing-and-Treatment.html ... and healthcare-associated infections (HAIs), demand has ...
(Date:8/20/2014)... 2014 Reportlinker.com announces that a new ... The Impact of Healthcare Reform (PPACA) ... http://www.reportlinker.com/p01618927/The-Impact-of-Healthcare-Reform-PPACA-On-the-US-IVD-Industry.html The "Patient Protection ... legislation that affects virtually every aspect of health ... to take effect now. IVD manufacturers who have ...
(Date:8/20/2014)... , Aug. 20, 2014 Reportlinker.com ... is available in its catalogue: ... Key Trends and Opportunities to 2018 ... Synopsis The report provides in depth market ... personal accident and health insurance segment, including: ...
Breaking Medicine Technology:The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 2The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 3The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 4The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 5The Market for Hospital-Acquired Infection Control (Sterilization, Disinfection, Testing and Treatment) 6The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 2The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 3The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 4The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 5The Impact of Healthcare Reform (PPACA) On the U.S. IVD Industry 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 2Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 3Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 4Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 5Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 6Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 7Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 8Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 9Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 10Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 11Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 12Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 13Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 14Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 15Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 16Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 17Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 18Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 19Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 20Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 21Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 22Personal Accident and Health Insurance in France, Key Trends and Opportunities to 2018 23
... , NEW YORK, Nov. 20 Medco Health Solutions, ... a transformation in American healthcare through an advanced, wired pharmacy ... fundamentally bending the cost curve downward -- making medicine smarter ... company today explained how the elements in its strategy enable ...
... , NEW YORK, Nov. 20 ... research report is available in its catalogue. ... Instruments - A World Market Analysis ... Measurement of blood pressure is not only ...
Cached Medicine Technology:Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 2Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 3Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 4Medco Reforming Healthcare with 'Smarter Medicine'; Wired, Transformational Pharmacy Model Advances Clinical Quality and Lowers Cost 5Reportlinker Adds Blood Pressure Monitoring & Measurement Instruments - A World Market Analysis 2Reportlinker Adds Blood Pressure Monitoring & Measurement Instruments - A World Market Analysis 3Reportlinker Adds Blood Pressure Monitoring & Measurement Instruments - A World Market Analysis 4Reportlinker Adds Blood Pressure Monitoring & Measurement Instruments - A World Market Analysis 5Reportlinker Adds Blood Pressure Monitoring & Measurement Instruments - A World Market Analysis 6Reportlinker Adds Blood Pressure Monitoring & Measurement Instruments - A World Market Analysis 7Reportlinker Adds Blood Pressure Monitoring & Measurement Instruments - A World Market Analysis 8Reportlinker Adds Blood Pressure Monitoring & Measurement Instruments - A World Market Analysis 9
Female Mini-VEST, Front Closure, X-Firm...
This compression garment can be used following Abdominoplasty, Tram Flap, Abdominal Liposuction, Lipoplasty, Suction,Lipectomy, Stomach Liposuction, Liposculpture, TummyTuck....
Ideal for lower abdominal procedures. Comes with a left side separating zipper....
Provides upper and lower arm support. Extends to the lower arm and across the shoulders. Has two columns of hook & eye closure for added adjustability....
Medicine Products: