Navigation Links
Pandemic flu strain could point way to universal vaccine
Date:1/10/2011

American Recovery and Reinvestment Act of 2009.

The nine patients studied were recruited through the Hope Clinic, the clinical division of the Emory Vaccine Center. They had a range of disease severities, from mild illness that waned after a few days to a severe case that required a two-month hospital stay including ventilator support. Most of the participants were in their 20s or 30s. Blood samples were usually taken about 10 days after the onset of symptoms.

The team of researchers identified white blood cells from the patients that made antibodies against flu virus, and then isolated the antibody genes from individual cells. They used the genes to produce antibodies in cell culture -- a total of 86 varieties -- and then tested which flu strains they reacted against.

Five antibodies isolated by the team could bind all the seasonal H1N1 flu strains from the last decade, the devastating "Spanish flu" strain from 1918 and also a pathogenic H5N1 avian flu strain.

Seasonal flu shots contain three inactivated viral strains, each grown in chicken eggs. Over the last decade, it was standard that one of the three is an H1N1 strain. However, vaccination with any one H1N1 strain doesn't usually result in protection against all of them that's why the 2009 strain could make so many people sick.

Some of the antibodies the team identified stick to the "stalk" region of part of the virus (a protein called hemagglutinin). Because this part of the virus doesn't change as much as other regions, scientists have proposed to make it the basis of a vaccine that could provide broader protection.

"Previously, this type of broadly protective, stalk-reactive antibody was thought to be very rare," Wrammert says. "In contrast, in the patients we studied, these stalk-reactive antibodies were surprisingly abundant."

The team tested whether three of the antibodies they isolated could protect mice against the 2009 H1N1 strain or two
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Most pandemic plans in Ontario hospitals have not been tested: Queens University study
2. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
3. Pandemic flu, like seasonal H1N1, shows signs of resisting Tamiflu
4. Personalizing medicine to prevent pandemics
5. Hand-washing, mask-wearing may limit transmission of pandemic flu
6. Fear of pandemic influenza clogs EDs even when disease is not present
7. Good Hygiene Does Slow Spread of Pandemic Flu
8. H1N1 Pandemic Flu Hits Pregnant Women Hard
9. NIH-funded scientists find 2009 H1N1 pandemic influenza vaccine protects mice from 1918 flu virus
10. H1N1 Pandemic Flu Even Milder Than Seasonal Strains
11. Disease transmission model says media coverage cuts infection rate and pandemic extent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 25, 2014 Residents at ... Community, recently showed their generous spirit by providing ... Catawba County Parenting Network- Grandparents Raising Grandchildren program. ... gathered around the largest Christmas tree on the ... purchased by residents of the Abernethy Village Association ...
(Date:12/24/2014)... Epigenetics finds applications in a large number of fields ... biology, and research for metabolic and genetic disorders. It ... used techniques for the discovery and development of cancer ... rapidly growing worldwide. In 2012, there were 14.1 million ... million people living with cancer (within five years of ...
(Date:12/24/2014)... 2014 Dr. Vu Ho, a Dallas ... his practice and med-spa with the addition of new ... of cosmetic treatments and services. , “Silk Peel is ... says Dr. Ho. “As a result it can address ... sun spots, discolorations or blemishes.” , Similar to microdermabrasion, ...
(Date:12/24/2014)... Mike Billings , PT, MS, CEEAA, President ... PT, MBA, GCS, Director of Professional Development to discuss ... of the Improving Medicare Post-Acute Care Transformation Act ... the Infinicast, the two leaders discuss how the IMPACT ... to standardize post-acute assessment data for quality, payment, and ...
(Date:12/24/2014)... Dec. 24, 2014 (HealthDay News) -- A new, injectable ... and Drug Administration. The agency on Tuesday approved ... those who are overweight and have at least one ... 2 diabetes or high cholesterol. Patients taking the ... low-calorie diet and exercise regularly, the FDA noted. ...
Breaking Medicine News(10 mins):Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:Global Epigenetics Market Was Valued at $413.24 Million in 2014 - New Research Report by MarketsandMarkets 2Health News:Global Epigenetics Market Was Valued at $413.24 Million in 2014 - New Research Report by MarketsandMarkets 3Health News:Dr. Vu Ho Expands Facial Plastic Surgery Practice to Include New Skin Care Treatment 2Health News:Latest Episode of Infinicast Features Infinity Rehab President Discussing IMPACT Act of 2014 and Changes for Post-Acute Therapy Providers in 2015 2Health News:FDA Approves New Weight-Loss Drug 2Health News:FDA Approves New Weight-Loss Drug 3
... of Catholics for Choice, issued the following statement on Respect ... Catholic Bishops holds its annual Respect Life Sunday. On this ... also respect the truth. A recent publication by the USCCB, ... on healthcare reform prove that the bishops, desire to promote ...
... , WILMINGTON, Del., Oct. 2 Nationwide Health ... of 4,000 production transactions processed through the NHIN ... CONNECT solution. , CONNECTfx was developed ... NHIEs, HIEs, and other collaborative healthcare organizations by ...
... NASHVILLE, Tenn., Oct. 2 Brookdale Senior Living Inc. (NYSE: ... Chief Financial Officer, will make a presentation regarding the Company ... New York on Monday, October 5, 2009, beginning at 3:30 ... live and can be accessed on the Internet at ...
... risk rises when transfused blood is more than 28 days old, ... suffered severe trauma and are given a major transfusion of red ... are twice as likely to die as those who receive fresher ... of 202 severe trauma patients who were treated with five or ...
... Oct. 2 Brent Phillips, a senior executive at ... officer of Aurora Medical Group. , (Logo: http://www.newscom.com/cgi-bin/prnh/20090303/CG78204LOGO-b ... the 960-physician medical group. , "Brent will ... Jeff Bailet, M.D., president of Aurora Medical Group. ...
... a long way in the last decade. Today, one can talk, ... even access the Web. Now imagine a cell phone that can ... test water quality after a major disaster like a hurricane or ... engineering at UCLA,s Henry Samueli School of Engineering and Applied Science, ...
Cached Medicine News:Health News:Respect Life and the Truth on Respect Life Sunday 2Health News:Respect Life and the Truth on Respect Life Sunday 3Health News:NHIT Processes Over 4,000 Production Transactions, Advances Adoption of NHIN Initiative 2Health News:Fresh Blood Boosts Survival in Trauma Patients 2Health News:Mayo Clinic Executive Brent Phillips to Join Aurora Medical Group as Chief Operating Officer 2Health News:NIH recognizes engineering professor's innovative research with major award 2Health News:NIH recognizes engineering professor's innovative research with major award 3
(Date:12/24/2014)... 23, 2014  The American Diabetes Association is ... for people with diabetes and that all people ... of statins, in keeping with recent changes to ... American College of Cardiology (ACC) and American Heart ... most recent changes to the Association,s annual revised ...
(Date:12/24/2014)...  Medical Science Liaisons play a large role in ... medical device industry and key stakeholders, the role of ... as the device industry relies on them to build ... benchmarking firm, Best Practices, LLC, one area where Medical ... by harnessing new technology to enable education. Online conferences ...
(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) ... Blood Glucose Market" report to their offering. ... market insight focuses on the developments in the self-monitoring ... . Reimbursement analysis and the effects of competitive ... than 73 SMBG meters have been performed, based on ...
Breaking Medicine Technology:New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4Role of Medical Science Liaisons Evolving in Medical Device Sector 2US Self-monitoring Blood Glucose Market 2
... Measuring the body temperatures of newborns with temporal artery ... by axillary (under arm) thermometry, the clinically recommended method ... to a new study reported in Advances in ... first published clinical analysis evaluating the accuracy of temporal ...
... 18, 2011 BB&T Capital Markets served as the ... Comfort, the leading developer, manufacturer and marketer of therapeutic ... sale to DJO Global, an international provider of medical ... management based in Vista, Calif. Dr. Comfort generated net ...
Cached Medicine Technology:Study Finds Exergen Temporal Artery Thermometry Accurate on Newborns 2Study Finds Exergen Temporal Artery Thermometry Accurate on Newborns 3BB&T Advises Dr. Comfort on Its Sale to DJO Global in Transaction Valued at $254.6 Million 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: